PMID- 28833377
OWN - NLM
STAT- MEDLINE
DCOM- 20171030
LR  - 20171030
IS  - 1531-8249 (Electronic)
IS  - 0364-5134 (Linking)
VI  - 82
IP  - 4
DP  - 2017 Oct
TI  - T1-/T2-weighted ratio differs in demyelinated cortex in multiple sclerosis.
PG  - 635-639
LID - 10.1002/ana.25019 [doi]
AB  - Detecting cortical demyelination in patients with multiple sclerosis (MS) is
      difficult. Using magnetic resonance imaging (MRI), ratio maps of T1-weighted
      (T1w) and T2-weighted (T2w) images may be sensitive to cortical myelin levels. In
      this MRI-histological study, postmortem in situ scans were acquired from 6
      cadavers with MS on a 3T MRI machine. Immunocytochemistry was used to correlate
      myelin status and cortical T1w/T2w measures. The results showed that the T1w/T2w 
      values significantly differed between demyelinated and myelinated cortex (p <
      0.001). The T1w/T2w ratio maps may be a relatively simple, clinically feasible
      method to assess cortical demyelination. Ann Neurol 2017;82:635-639.
CI  - (c) 2017 American Neurological Association.
FAU - Nakamura, Kunio
AU  - Nakamura K
AD  - Department of Biomedical Engineering, Lerner Research Institute, Cleveland
      Clinic.
FAU - Chen, Jacqueline T
AU  - Chen JT
AD  - Department of Neuroscience, Lerner Research Institute, Cleveland Clinic.
FAU - Ontaneda, Daniel
AU  - Ontaneda D
AD  - Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic,
      Cleveland, OH.
FAU - Fox, Robert J
AU  - Fox RJ
AD  - Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic,
      Cleveland, OH.
FAU - Trapp, Bruce D
AU  - Trapp BD
AD  - Department of Neuroscience, Lerner Research Institute, Cleveland Clinic.
LA  - eng
PT  - Journal Article
DEP - 20170921
PL  - United States
TA  - Ann Neurol
JT  - Annals of neurology
JID - 7707449
RN  - 0 (Myelin Proteolipid Protein)
SB  - IM
MH  - Aged
MH  - Cerebral Cortex/*diagnostic imaging
MH  - Diagnosis
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - *Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*diagnostic imaging
MH  - Myelin Proteolipid Protein/metabolism
MH  - Myelin Sheath/*pathology
EDAT- 2017/08/24 06:00
MHDA- 2017/10/31 06:00
CRDT- 2017/08/24 06:00
PHST- 2017/02/27 00:00 [received]
PHST- 2017/08/02 00:00 [revised]
PHST- 2017/08/02 00:00 [accepted]
PHST- 2017/08/24 06:00 [pubmed]
PHST- 2017/10/31 06:00 [medline]
PHST- 2017/08/24 06:00 [entrez]
AID - 10.1002/ana.25019 [doi]
PST - ppublish
SO  - Ann Neurol. 2017 Oct;82(4):635-639. doi: 10.1002/ana.25019. Epub 2017 Sep 21.