PMID- 28831593
OWN - NLM
STAT- MEDLINE
DCOM- 20180625
LR  - 20181113
IS  - 1435-4373 (Electronic)
IS  - 0934-9723 (Linking)
VI  - 36
IP  - 12
DP  - 2017 Dec
TI  - Impact of rapid diagnosis of Staphylococcus aureus bacteremia from positive blood
      cultures on patient management.
PG  - 2469-2473
LID - 10.1007/s10096-017-3086-5 [doi]
AB  - We have performed a retrospective, before-after comparison of turnaround time and
      therapy adjustment parameters before and after the introduction of
      matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) plus mecA 
      polymerase chain reaction (PCR) for the identification of methicillin-resistant
      Staphylococcus aureus (MRSA) in positive blood cultures. There were 227 episodes 
      of S. aureus bacteremia during the study periods. The pre-MALDI-TOF and
      post-MALDI-TOF groups included 133 and 94 patients, respectively. The two rapid
      methods performed sequentially decreased the turnaround time of MRSA
      identification by nearly 50% (2.06 +/- 1.95 vs. 3.95 +/- 1.70 days). There was no
      significant reduction in the length of hospitalization (28.27 +/- 32.16 vs. 28.62
      +/- 28.75 days). In both groups, the adequacy of the empirical antibacterial
      therapy was similar (59.49% vs. 51.31%), but the optimization of the therapy was 
      more frequent in the post-MALDI-TOF group. Routine implementation of these
      techniques provides results earlier than conventional methods and increases the
      proportion of episodes with adequate change of empirical to directed
      antimicrobial therapy.
FAU - Romero-Gomez, M P
AU  - Romero-Gomez MP
AD  - Servicio de Microbiologia Clinica, Hospital Universitario La Paz, IdiPAZ, Paseo
      de La Castellana, 261, 28046, Madrid, Spain. mpromero.hulp@salud.madrid.org.
FAU - Cendejas-Bueno, E
AU  - Cendejas-Bueno E
AD  - Servicio de Microbiologia Clinica, Hospital Universitario La Paz, IdiPAZ, Paseo
      de La Castellana, 261, 28046, Madrid, Spain.
FAU - Garcia Rodriguez, J
AU  - Garcia Rodriguez J
AD  - Servicio de Microbiologia Clinica, Hospital Universitario La Paz, IdiPAZ, Paseo
      de La Castellana, 261, 28046, Madrid, Spain.
FAU - Mingorance, J
AU  - Mingorance J
AD  - Servicio de Microbiologia Clinica, Hospital Universitario La Paz, IdiPAZ, Paseo
      de La Castellana, 261, 28046, Madrid, Spain.
LA  - eng
PT  - Journal Article
DEP - 20170823
PL  - Germany
TA  - Eur J Clin Microbiol Infect Dis
JT  - European journal of clinical microbiology & infectious diseases : official
      publication of the European Society of Clinical Microbiology
JID - 8804297
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Bacteremia
MH  - Bacteriological Techniques
MH  - Blood Culture
MH  - Female
MH  - Humans
MH  - Length of Stay
MH  - Male
MH  - Middle Aged
MH  - Polymerase Chain Reaction/methods
MH  - Retrospective Studies
MH  - Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization/methods
MH  - Staphylococcal Infections/*diagnosis/*microbiology/therapy
MH  - *Staphylococcus aureus/classification/genetics
EDAT- 2017/08/24 06:00
MHDA- 2018/06/26 06:00
CRDT- 2017/08/24 06:00
PHST- 2017/05/07 00:00 [received]
PHST- 2017/07/31 00:00 [accepted]
PHST- 2017/08/24 06:00 [pubmed]
PHST- 2018/06/26 06:00 [medline]
PHST- 2017/08/24 06:00 [entrez]
AID - 10.1007/s10096-017-3086-5 [doi]
AID - 10.1007/s10096-017-3086-5 [pii]
PST - ppublish
SO  - Eur J Clin Microbiol Infect Dis. 2017 Dec;36(12):2469-2473. doi:
      10.1007/s10096-017-3086-5. Epub 2017 Aug 23.