PMID- 28825315
OWN - NLM
STAT- MEDLINE
DCOM- 20190208
LR  - 20190215
IS  - 1468-2982 (Electronic)
IS  - 0333-1024 (Linking)
VI  - 38
IP  - 6
DP  - 2018 May
TI  - Medication overuse reinstates conditioned pain modulation in women with migraine.
PG  - 1148-1158
LID - 10.1177/0333102417727545 [doi]
AB  - Background This study investigated the effects of medication overuse and
      withdrawal on modulation of pain processing in women with migraine. Temporal
      summation of laser-evoked thermal pain was used to measure the effects of
      conditioned pain modulation. Methods 36 female participants (12 healthy
      volunteers, 12 with episodic migraine and 12 with medication overuse headache)
      were included in a two session protocol. Medication overuse headache subjects
      were also tested three weeks after medication overuse headache withdrawal.
      Mechanical and laser-evoked thermal pain thresholds were measured on the back of 
      the non-dominant hand where, later, temporal summation of laser-evoked thermal
      pain to repetitive thermal stimuli was elicited for 30 min, at an intensity
      producing moderate pain. Between the 10(th) and 20(th) minutes, the contralateral
      foot was immersed into a water bath at a not painful (30) or painfully cold (8;
      conditioned pain modulation) temperature. Results Episodic migraine, medication
      overuse headache and medication overuse headache withdrawal were associated with 
      an increase in extracephalic temporal summation of laser-evoked thermal pain as
      compared to healthy volunteer subjects, while there was no alteration of
      laser-evoked thermal and mechanical extracephalic pain thresholds in these
      subjects. Conditioned pain modulation was highly efficient in temporal summation 
      of laser-evoked thermal pain in healthy volunteer subjects, with a solid
      post-effect (reduction of pain). Conditioned pain modulation was still present,
      but reduced, in episodic migraine. By contrast, conditioned pain modulation was
      normal in medication overuse headache and strongly reduced in medication overuse 
      headache withdrawal. Furthermore, in medication overuse headache withdrawal, the 
      post-effect was no longer a decrease, but a facilitation of pain. Conclusions
      These data show that a decrease in conditioned pain modulation does not underlie 
      medication overuse headache in women. On the contrary, medication overuse
      reinstated conditioned pain modulation in female migraine patients. They also
      identify different phenotypes of pain modulation in migraine patients.
      Registration number N degrees 2008-A00471-54.
FAU - Guy, Nathalie
AU  - Guy N
AD  - 1 137663 Universite Clermont Auvergne , Clermont-Ferrand, France.
AD  - 2 55174 CHU Clermont-Ferrand , Clermont-Ferrand, France.
AD  - 3 Inserm U1107, Neuro-Dol, Clermont-Ferrand, France.
FAU - Voisin, Daniel
AU  - Voisin D
AD  - 4 Neurocentre Magendie, Inserm U1215, Bordeaux, France.
AD  - 5 27086 Universite de Bordeaux , Bordeaux, France.
FAU - Mulliez, Aurelien
AU  - Mulliez A
AD  - 2 55174 CHU Clermont-Ferrand , Clermont-Ferrand, France.
FAU - Clavelou, Pierre
AU  - Clavelou P
AD  - 1 137663 Universite Clermont Auvergne , Clermont-Ferrand, France.
AD  - 2 55174 CHU Clermont-Ferrand , Clermont-Ferrand, France.
AD  - 3 Inserm U1107, Neuro-Dol, Clermont-Ferrand, France.
FAU - Dallel, Radhouane
AU  - Dallel R
AD  - 1 137663 Universite Clermont Auvergne , Clermont-Ferrand, France.
AD  - 2 55174 CHU Clermont-Ferrand , Clermont-Ferrand, France.
AD  - 3 Inserm U1107, Neuro-Dol, Clermont-Ferrand, France.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170820
PL  - England
TA  - Cephalalgia
JT  - Cephalalgia : an international journal of headache
JID - 8200710
SB  - IM
MH  - Adult
MH  - Female
MH  - Headache Disorders, Secondary/*physiopathology
MH  - Humans
MH  - Migraine Disorders/*physiopathology
MH  - Pain Threshold/*physiology
MH  - Prescription Drug Overuse
MH  - Substance Withdrawal Syndrome/*physiopathology
OTO - NOTNLM
OT  - *Migraine
OT  - *conditioned pain modulation
OT  - *medication overuse headache
OT  - *pain summation
EDAT- 2017/08/22 06:00
MHDA- 2019/02/09 06:00
CRDT- 2017/08/22 06:00
PHST- 2017/08/22 06:00 [pubmed]
PHST- 2019/02/09 06:00 [medline]
PHST- 2017/08/22 06:00 [entrez]
AID - 10.1177/0333102417727545 [doi]
PST - ppublish
SO  - Cephalalgia. 2018 May;38(6):1148-1158. doi: 10.1177/0333102417727545. Epub 2017
      Aug 20.