PMID- 28817389
DCOM- 20171016
LR  - 20171016
IS  - 1531-7021 (Electronic)
IS  - 1040-8738 (Linking)
VI  - 28
IP  - 6
DP  - 2017 Nov
TI  - Congenital anomalies of the optic disc: insights from optical coherence
      tomography imaging.
PG  - 579-586
LID - 10.1097/ICU.0000000000000425 [doi]
AB  - PURPOSE OF REVIEW: Congenital anomalies of the optic nerve are rare but
      significant causes of visual dysfunction in children and adults. Accurate
      diagnosis is dependent on a thorough funduscopic examination, but can be enhanced
      by imaging information garnered from optical coherence tomography (OCT). We
      review common congenital optic nerve anomalies, including optic disc pit, optic
      nerve coloboma, morning glory disc anomaly, and hypoplasia of the optic nerve,
      review their systemic associations, and discuss insights from OCT imaging. RECENT
      FINDINGS: Optic disc pits are a result of a defect in the lamina cribrosa and
      abnormal vitreomacular adhesions have been shown to cause maculopathy. In
      patients with optic nerve colobomas, OCT can be instrumental in diagnosing
      choroidal neovascularization, a rare but visually devastating complication. The
      pathogenesis of morning glory disc anomaly has been more clearly elucidated by
      OCT as occurring from a secondary postnatal mesenchymal abnormality rather than
      only the initial neuroectodermal dysgenesis of the terminal optic stalk in
      isolation. OCT studies of optic nerve hypoplasia have demonstrated significant
      thinning of the inner and outer retinal layers of the perifoveal region and
      thicker layers in the fovea itself, resulting in a foveal hypoplasia-like
      pathology, that is, significantly correlated to poorer visual outcomes. SUMMARY: 
      OCT provides detailed in-vivo analysis of these anatomic anomalies and their
      resulting pathologies, shedding new insights on the pathogenesis, diagnosis, and 
      potential visual outcomes of these conditions in children. Further study
      employing OCT to elucidate structure-function relationships of congenital optic
      nerve anomalies will help expand the role of OCT in clinical practice related to 
      diagnosis, prognosis, and management of these entities.
FAU - Jeng-Miller, Karen W
AU  - Jeng-Miller KW
AD  - aMassachusetts Eye and Ear Infirmary bDepartment of Ophthalmology, Harvard
      Medical School, Boston, Massachusetts, USA.
FAU - Cestari, Dean M
AU  - Cestari DM
FAU - Gaier, Eric D
AU  - Gaier ED
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Ophthalmol
JT  - Current opinion in ophthalmology
JID - 9011108
RN  - Coloboma of optic nerve
SB  - IM
MH  - Coloboma/*diagnosis
MH  - Humans
MH  - Optic Disk/*abnormalities
MH  - Optic Nerve/*abnormalities
MH  - *Tomography, Optical Coherence/methods
EDAT- 2017/08/18 06:00
MHDA- 2017/10/17 06:00
CRDT- 2017/08/18 06:00
PHST- 2017/08/18 06:00 [pubmed]
PHST- 2017/10/17 06:00 [medline]
PHST- 2017/08/18 06:00 [entrez]
AID - 10.1097/ICU.0000000000000425 [doi]
PST - ppublish
SO  - Curr Opin Ophthalmol. 2017 Nov;28(6):579-586. doi: 10.1097/ICU.0000000000000425.