PMID- 28810146
OWN - NLM
STAT- MEDLINE
DCOM- 20170911
LR  - 20190302
IS  - 1878-3686 (Electronic)
IS  - 1535-6108 (Linking)
VI  - 32
IP  - 2
DP  - 2017 Aug 14
TI  - Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using
      Tumor-Educated Platelets.
PG  - 238-252.e9
LID - S1535-6108(17)30296-9 [pii]
LID - 10.1016/j.ccell.2017.07.004 [doi]
AB  - Blood-based liquid biopsies, including tumor-educated blood platelets (TEPs),
      have emerged as promising biomarker sources for non-invasive detection of cancer.
      Here we demonstrate that particle-swarm optimization (PSO)-enhanced algorithms
      enable efficient selection of RNA biomarker panels from platelet RNA-sequencing
      libraries (n = 779). This resulted in accurate TEP-based detection of early- and 
      late-stage non-small-cell lung cancer (n = 518 late-stage validation cohort,
      accuracy, 88%; AUC, 0.94; 95% CI, 0.92-0.96; p < 0.001; n = 106 early-stage
      validation cohort, accuracy, 81%; AUC, 0.89; 95% CI, 0.83-0.95; p < 0.001),
      independent of age of the individuals, smoking habits, whole-blood storage time, 
      and various inflammatory conditions. PSO enabled selection of gene panels to
      diagnose cancer from TEPs, suggesting that swarm intelligence may also benefit
      the optimization of diagnostics readout of other liquid biopsy biosources.
CI  - Copyright (c) 2017 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Best, Myron G
AU  - Best MG
AD  - Department of Neurosurgery, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of
      Pathology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan
      1117, 1081 HV Amsterdam, the Netherlands; Brain Tumor Center Amsterdam, VU
      University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV
      Amsterdam, the Netherlands. Electronic address: m.best@vumc.nl.
FAU - Sol, Nik
AU  - Sol N
AD  - Brain Tumor Center Amsterdam, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of
      Neurology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan
      1117, 1081 HV Amsterdam, the Netherlands.
FAU - In 't Veld, Sjors G J G
AU  - In 't Veld SGJG
AD  - Department of Neurosurgery, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Brain Tumor
      Center Amsterdam, VU University Medical Center, Cancer Center Amsterdam, De
      Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Vancura, Adrienne
AU  - Vancura A
AD  - Department of Neurosurgery, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Brain Tumor
      Center Amsterdam, VU University Medical Center, Cancer Center Amsterdam, De
      Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Muller, Mirte
AU  - Muller M
AD  - Department of Thoracic Oncology, The Netherlands Cancer Institute - Antoni van
      Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
FAU - Niemeijer, Anna-Larissa N
AU  - Niemeijer AN
AD  - Department of Pulmonary Diseases, VU University Medical Center, De Boelelaan
      1117, 1081 HV Amsterdam, the Netherlands.
FAU - Fejes, Aniko V
AU  - Fejes AV
AD  - Department of Neurosurgery, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Brain Tumor
      Center Amsterdam, VU University Medical Center, Cancer Center Amsterdam, De
      Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Clinical Institute of
      Laboratory Medicine, Medical University of Vienna, Spitalgasse 23, 1090 Vienna,
      Austria.
FAU - Tjon Kon Fat, Lee-Ann
AU  - Tjon Kon Fat LA
AD  - Department of Radiation Sciences, Oncology, Umea University, 90185 Umea, Sweden.
FAU - Huis In 't Veld, Anna E
AU  - Huis In 't Veld AE
AD  - Department of Pulmonary Diseases, VU University Medical Center, De Boelelaan
      1117, 1081 HV Amsterdam, the Netherlands.
FAU - Leurs, Cyra
AU  - Leurs C
AD  - Department of Neurology, VU University Medical Center, Cancer Center Amsterdam,
      De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; MS Center Amsterdam, VU
      University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Le Large, Tessa Y
AU  - Le Large TY
AD  - Department of Surgery, VU University Medical Center, Cancer Center Amsterdam, De 
      Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Meijer, Laura L
AU  - Meijer LL
AD  - Department of Surgery, VU University Medical Center, Cancer Center Amsterdam, De 
      Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Kooi, Irsan E
AU  - Kooi IE
AD  - Department of Clinical Genetics, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Rustenburg, Francois
AU  - Rustenburg F
AD  - Department of Neurosurgery, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of
      Pathology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan
      1117, 1081 HV Amsterdam, the Netherlands; Brain Tumor Center Amsterdam, VU
      University Medical Center, Cancer Center Amsterdam, De Boelelaan 1117, 1081 HV
      Amsterdam, the Netherlands.
FAU - Schellen, Pepijn
AU  - Schellen P
AD  - Department of Neurosurgery, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Brain Tumor
      Center Amsterdam, VU University Medical Center, Cancer Center Amsterdam, De
      Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Verschueren, Heleen
AU  - Verschueren H
AD  - Department of Neurosurgery, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Brain Tumor
      Center Amsterdam, VU University Medical Center, Cancer Center Amsterdam, De
      Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; thromboDx B.V., 1098 EA
      Amsterdam, the Netherlands.
FAU - Post, Edward
AU  - Post E
AD  - Department of Neurosurgery, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Brain Tumor
      Center Amsterdam, VU University Medical Center, Cancer Center Amsterdam, De
      Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; thromboDx B.V., 1098 EA
      Amsterdam, the Netherlands.
FAU - Wedekind, Laurine E
AU  - Wedekind LE
AD  - Department of Neurosurgery, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Brain Tumor
      Center Amsterdam, VU University Medical Center, Cancer Center Amsterdam, De
      Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Bracht, Jillian
AU  - Bracht J
AD  - Department of Neurosurgery, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Esenkbrink, Michelle
AU  - Esenkbrink M
AD  - Department of Neurosurgery, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Wils, Leon
AU  - Wils L
AD  - Department of Neurosurgery, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Favaro, Francesca
AU  - Favaro F
AD  - Department of Neurosurgery, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Schoonhoven, Jilian D
AU  - Schoonhoven JD
AD  - Department of Neurosurgery, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Tannous, Jihane
AU  - Tannous J
AD  - Department of Neurology, Massachusetts General Hospital and Neuroscience Program,
      Harvard Medical School, 149 13(th) Street, Charlestown, MA 02129, USA.
FAU - Meijers-Heijboer, Hanne
AU  - Meijers-Heijboer H
AD  - Department of Clinical Genetics, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Kazemier, Geert
AU  - Kazemier G
AD  - Department of Surgery, VU University Medical Center, Cancer Center Amsterdam, De 
      Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Giovannetti, Elisa
AU  - Giovannetti E
AD  - Department of Medical Oncology, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Reijneveld, Jaap C
AU  - Reijneveld JC
AD  - Brain Tumor Center Amsterdam, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of
      Neurology, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan
      1117, 1081 HV Amsterdam, the Netherlands.
FAU - Idema, Sander
AU  - Idema S
AD  - Department of Neurosurgery, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Killestein, Joep
AU  - Killestein J
AD  - Department of Neurology, VU University Medical Center, Cancer Center Amsterdam,
      De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; MS Center Amsterdam, VU
      University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Heger, Michal
AU  - Heger M
AD  - Department of Surgery, Amsterdam Medical Center, Meibergdreef 9, 1105 AZ
      Amsterdam, the Netherlands.
FAU - de Jager, Saskia C
AU  - de Jager SC
AD  - Department of Experimental Cardiology, Utrecht University Medical Center,
      Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
FAU - Urbanus, Rolf T
AU  - Urbanus RT
AD  - Laboratory of Clinical Chemistry and Hematology, Utrecht University Medical
      Center, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
FAU - Hoefer, Imo E
AU  - Hoefer IE
AD  - Laboratory of Clinical Chemistry and Hematology, Utrecht University Medical
      Center, Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
FAU - Pasterkamp, Gerard
AU  - Pasterkamp G
AD  - Department of Experimental Cardiology, Utrecht University Medical Center,
      Heidelberglaan 100, 3584 CX Utrecht, the Netherlands.
FAU - Mannhalter, Christine
AU  - Mannhalter C
AD  - Clinical Institute of Laboratory Medicine, Medical University of Vienna,
      Spitalgasse 23, 1090 Vienna, Austria.
FAU - Gomez-Arroyo, Jose
AU  - Gomez-Arroyo J
AD  - Department of Pulmonary Diseases, VU University Medical Center, De Boelelaan
      1117, 1081 HV Amsterdam, the Netherlands.
FAU - Bogaard, Harm-Jan
AU  - Bogaard HJ
AD  - Department of Pulmonary Diseases, VU University Medical Center, De Boelelaan
      1117, 1081 HV Amsterdam, the Netherlands.
FAU - Noske, David P
AU  - Noske DP
AD  - Department of Neurosurgery, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Brain Tumor
      Center Amsterdam, VU University Medical Center, Cancer Center Amsterdam, De
      Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Vandertop, W Peter
AU  - Vandertop WP
AD  - Department of Neurosurgery, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Brain Tumor
      Center Amsterdam, VU University Medical Center, Cancer Center Amsterdam, De
      Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - van den Broek, Daan
AU  - van den Broek D
AD  - Department of Clinical Chemistry, The Netherlands Cancer Institute - Antoni van
      Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands.
FAU - Ylstra, Bauke
AU  - Ylstra B
AD  - Department of Pathology, VU University Medical Center, Cancer Center Amsterdam,
      De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands.
FAU - Nilsson, R Jonas A
AU  - Nilsson RJA
AD  - Department of Neurosurgery, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of
      Radiation Sciences, Oncology, Umea University, 90185 Umea, Sweden.
FAU - Wesseling, Pieter
AU  - Wesseling P
AD  - Department of Pathology, VU University Medical Center, Cancer Center Amsterdam,
      De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Brain Tumor Center
      Amsterdam, VU University Medical Center, Cancer Center Amsterdam, De Boelelaan
      1117, 1081 HV Amsterdam, the Netherlands; Department of Pathology, Princess
      Maxima Center for Pediatric Oncology and University Medical Center Utrecht,
      Lundlaan 6, 3584 EA Utrecht, the Netherlands.
FAU - Karachaliou, Niki
AU  - Karachaliou N
AD  - Translational Research Unit, Dr. Rosell Oncology Institute, Quiron Dexeus
      University Hospital, Calle Sabine Arana 5-19, 08028 Barcelona, Spain.
FAU - Rosell, Rafael
AU  - Rosell R
AD  - Translational Research Unit, Dr. Rosell Oncology Institute, Quiron Dexeus
      University Hospital, Calle Sabine Arana 5-19, 08028 Barcelona, Spain; Pangaea
      Biotech SL, Calle Sabine Arana 5-19, 08028 Barcelona, Spain; Catalan Institute of
      Oncology, Hospital Germans Trias i Pujol, Carretera de Canyet, 08916 Barcelona,
      Spain; Molecular Oncology Research (MORe) Foundation, Calle Sabine Arana 5-19,
      08028 Barcelona, Spain.
FAU - Lee-Lewandrowski, Elizabeth
AU  - Lee-Lewandrowski E
AD  - Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 
      149 13(th) Street, Charlestown, MA 02129, USA.
FAU - Lewandrowski, Kent B
AU  - Lewandrowski KB
AD  - Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 
      149 13(th) Street, Charlestown, MA 02129, USA.
FAU - Tannous, Bakhos A
AU  - Tannous BA
AD  - Department of Neurology, Massachusetts General Hospital and Neuroscience Program,
      Harvard Medical School, 149 13(th) Street, Charlestown, MA 02129, USA.
FAU - de Langen, Adrianus J
AU  - de Langen AJ
AD  - Department of Pulmonary Diseases, VU University Medical Center, De Boelelaan
      1117, 1081 HV Amsterdam, the Netherlands.
FAU - Smit, Egbert F
AU  - Smit EF
AD  - Department of Thoracic Oncology, The Netherlands Cancer Institute - Antoni van
      Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands;
      Department of Pulmonary Diseases, VU University Medical Center, De Boelelaan
      1117, 1081 HV Amsterdam, the Netherlands.
FAU - van den Heuvel, Michel M
AU  - van den Heuvel MM
AD  - Department of Thoracic Oncology, The Netherlands Cancer Institute - Antoni van
      Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, the Netherlands;
      Department of Respiratory Diseases, Radboud University Medical Center, 6500 HB
      Nijmegen, the Netherlands.
FAU - Wurdinger, Thomas
AU  - Wurdinger T
AD  - Department of Neurosurgery, VU University Medical Center, Cancer Center
      Amsterdam, De Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Brain Tumor
      Center Amsterdam, VU University Medical Center, Cancer Center Amsterdam, De
      Boelelaan 1117, 1081 HV Amsterdam, the Netherlands; Department of Neurology,
      Massachusetts General Hospital and Neuroscience Program, Harvard Medical School, 
      149 13(th) Street, Charlestown, MA 02129, USA. Electronic address:
      t.wurdinger@vumc.nl.
LA  - eng
GR  - P01 CA069246/CA/NCI NIH HHS/United States
GR  - R21 CA176359/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cancer Cell
JT  - Cancer cell
JID - 101130617
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Algorithms
MH  - *Artificial Intelligence
MH  - Biomarkers, Tumor
MH  - Blood Platelets/*physiology
MH  - Carcinoma, Non-Small-Cell Lung/blood/*diagnosis/genetics
MH  - Cohort Studies
MH  - Diagnosis, Computer-Assisted/*methods
MH  - Female
MH  - Gene Expression Profiling
MH  - High-Throughput Nucleotide Sequencing
MH  - Humans
MH  - Inflammation/blood/diagnosis/genetics
MH  - Lung Neoplasms/blood/*diagnosis/genetics
MH  - Male
MH  - Middle Aged
MH  - Support Vector Machine
PMC - PMC6381325
OTO - NOTNLM
OT  - *NSCLC
OT  - *RNA
OT  - *blood platelets
OT  - *cancer diagnostics
OT  - *liquid biopsies
OT  - *particle-swarm optimization
OT  - *self-learning algorithms
OT  - *splicing
OT  - *swarm intelligence
OT  - *tumor-educated platelets
EDAT- 2017/08/16 06:00
MHDA- 2017/09/12 06:00
CRDT- 2017/08/16 06:00
PHST- 2017/02/03 00:00 [received]
PHST- 2017/05/17 00:00 [revised]
PHST- 2017/07/13 00:00 [accepted]
PHST- 2017/08/16 06:00 [entrez]
PHST- 2017/08/16 06:00 [pubmed]
PHST- 2017/09/12 06:00 [medline]
AID - S1535-6108(17)30296-9 [pii]
AID - 10.1016/j.ccell.2017.07.004 [doi]
PST - ppublish
SO  - Cancer Cell. 2017 Aug 14;32(2):238-252.e9. doi: 10.1016/j.ccell.2017.07.004.