PMID- 28801919
OWN - NLM
STAT- MEDLINE
DCOM- 20171020
LR  - 20180322
IS  - 1097-0215 (Electronic)
IS  - 0020-7136 (Linking)
VI  - 141
IP  - 11
DP  - 2017 Dec 1
TI  - Familial associations of female breast cancer with other cancers.
PG  - 2253-2259
LID - 10.1002/ijc.30927 [doi]
AB  - Familial risks of breast cancer (BC) are well established but whether BC clusters
      with other, i.e. discordant, cancers is less certain but of interest for the
      identification of common genetic and possible environmental factors contributing 
      to a general cancer susceptibility. We apply a novel approach to search for
      familial associations of BC with other (discordant) cancers based on the Swedish 
      Family-Cancer Database. Relative risks (RRs) were calculated for BC in families
      with increasing numbers of patients with discordant cancer X, and conversely,
      familial RRs for cancer X in families with increasing numbers of BC patients.
      Joint p-values were calculated from independent analyses. The total number of
      familial BCs was 12,266, 14.9% with one first-degree relative with BC and 1.2%
      with at least 2 affected relatives. Ovarian and prostate cancers showed the
      strongest associations with BC (p-value <10(-11) ). The p-value for melanoma was 
      <10(-6) , for stomach and male colorectal cancer <2.5 x 10(-6) , for cancer of
      unknown primary <2.5 x 10(-5) and for lung cancer <5 x 10(-5) . Significance
      level <5 x 10(-4) was reached with pancreatic cancer. The remaining associations 
      (p < 0.0025) included thyroid, endometrial, testicular, eye cancers (uveal
      melanoma), nervous system and endocrine tumors and non-Hodgkin lymphoma. The RR
      for BC increased by increasing numbers of patients with any cancer in family
      members and it reached 1.62 when three or more family members were affected. The 
      results suggest that BC shares susceptibility with a number of other cancers.
      This might alert genetic counselors and challenge approaches for gene and
      gene-environment identification.
CI  - (c) 2017 UICC.
FAU - Zheng, Guoqiao
AU  - Zheng G
AUID- ORCID: 0000-0003-4337-9017
AD  - Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ),
      Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany.
FAU - Yu, Hongyao
AU  - Yu H
AD  - Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ),
      Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany.
FAU - Hemminki, Akseli
AU  - Hemminki A
AUID- ORCID: 0000-0001-7103-8530
AD  - Cancer Gene Therapy Group, Faculty of Medicine, University of Helsinki, Helsinki,
      Finland.
AD  - Helsinki University Hospital Comprehensive Cancer Center, Helsinki, Finland.
FAU - Forsti, Asta
AU  - Forsti A
AD  - Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ),
      Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany.
AD  - Center for Primary Health Care Research, Lund University, 205 02, Malmo, Sweden.
FAU - Sundquist, Kristina
AU  - Sundquist K
AD  - Center for Primary Health Care Research, Lund University, 205 02, Malmo, Sweden.
FAU - Hemminki, Kari
AU  - Hemminki K
AD  - Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ),
      Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany.
AD  - Center for Primary Health Care Research, Lund University, 205 02, Malmo, Sweden.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170826
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
SB  - IM
MH  - Breast Neoplasms/epidemiology/*genetics
MH  - Female
MH  - Genetic Predisposition to Disease/*epidemiology
MH  - Humans
MH  - Male
MH  - Neoplasms/epidemiology/genetics
MH  - Pedigree
MH  - Registries
MH  - Risk
MH  - Sweden/epidemiology
OTO - NOTNLM
OT  - *discordant cancer
OT  - *familial cancer
OT  - *familial risk
OT  - *genetic association
EDAT- 2017/08/13 06:00
MHDA- 2017/10/21 06:00
CRDT- 2017/08/13 06:00
PHST- 2017/06/28 00:00 [received]
PHST- 2017/08/03 00:00 [accepted]
PHST- 2017/08/13 06:00 [pubmed]
PHST- 2017/10/21 06:00 [medline]
PHST- 2017/08/13 06:00 [entrez]
AID - 10.1002/ijc.30927 [doi]
PST - ppublish
SO  - Int J Cancer. 2017 Dec 1;141(11):2253-2259. doi: 10.1002/ijc.30927. Epub 2017 Aug
      26.