PMID- 28746260
OWN - NLM
STAT- MEDLINE
DCOM- 20180110
LR  - 20180110
IS  - 1532-0987 (Electronic)
IS  - 0891-3668 (Linking)
VI  - 37
IP  - 1
DP  - 2018 Jan
TI  - Perinatal HIV Infection and Exposure and Their Association With Dental Caries in 
      Nigerian Children.
PG  - 59-65
LID - 10.1097/INF.0000000000001702 [doi]
AB  - BACKGROUND: Although HIV infection is associated with well-known oral
      pathologies, there remains a dearth of comparative studies aimed at determining
      the association between HIV infection/exposure and early childhood caries.
      METHODS: This is a cross-sectional study using a convenience sample of 3 groups
      of children receiving care at a tertiary care hospital in Nigeria. The groups
      include HIV infected (HI), HIV exposed but uninfected and HIV-unexposed and
      -uninfected children 6 through 72 months of age. Medical records were reviewed,
      and caregivers were interviewed for sociodemographic, maternal and birth factors 
      as well as early feeding and dietary information. Oral examinations were
      performed by trained dentist examiners. RESULTS: Of 335 children enrolled, 33
      (9.9%) presented with caries. In an adjusted analysis, compared with
      HIV-unexposed and -uninfected children, HI children had significantly greater
      odds of having caries (odds ratio = 2.58; 95% confidence interval: 1.04-6.40; P =
      0.04), but there was no statistically significant difference in HIV exposed but
      uninfected children (odds ratio = 2.01; 95% confidence interval: 0.56-7.23; P =
      0.28). Factors significantly associated with higher caries prevalence include low
      CD4 counts and percentage, older age, longer duration of breastfeeding and
      spontaneous membrane rupture during delivery. CONCLUSIONS: Caries was more
      prevalent in HI children. These findings support the need to target HI children
      for oral health prevention and treatment services particularly in Nigeria and
      other developing countries.
FAU - Coker, Modupe
AU  - Coker M
FAU - El-Kamary, Samer S
AU  - El-Kamary SS
FAU - Enwonwu, Cyril
AU  - Enwonwu C
FAU - Blattner, William
AU  - Blattner W
FAU - Langenberg, Patricia
AU  - Langenberg P
FAU - Mongodin, Emmanuel
AU  - Mongodin E
FAU - Akhigbe, Paul
AU  - Akhigbe P
FAU - Obuekwe, Ozo
AU  - Obuekwe O
FAU - Omoigberale, Austin
AU  - Omoigberale A
FAU - Charurat, Manhattan
AU  - Charurat M
LA  - eng
GR  - D43 TW001041/TW/FIC NIH HHS/United States
GR  - R01 DE025174/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PL  - United States
TA  - Pediatr Infect Dis J
JT  - The Pediatric infectious disease journal
JID - 8701858
SB  - IM
MH  - Child
MH  - Child, Preschool
MH  - Cross-Sectional Studies
MH  - Dental Caries/*complications/*epidemiology
MH  - Female
MH  - HIV Infections/*complications/*epidemiology/transmission
MH  - Humans
MH  - Infant
MH  - Infectious Disease Transmission, Vertical
MH  - Male
MH  - Nigeria/epidemiology
MH  - Pregnancy
MH  - Pregnancy Complications, Infectious
MH  - Risk Factors
PMC - PMC5725234
MID - NIHMS893749
EDAT- 2017/07/27 06:00
MHDA- 2018/01/11 06:00
CRDT- 2017/07/27 06:00
PMCR- 2019/01/01 00:00
PHST- 2019/01/01 00:00 [pmc-release]
PHST- 2017/07/27 06:00 [pubmed]
PHST- 2018/01/11 06:00 [medline]
PHST- 2017/07/27 06:00 [entrez]
AID - 10.1097/INF.0000000000001702 [doi]
PST - ppublish
SO  - Pediatr Infect Dis J. 2018 Jan;37(1):59-65. doi: 10.1097/INF.0000000000001702.