PMID- 28728858
OWN - NLM
STAT- In-Process
LR  - 20171124
IS  - 0151-9638 (Print)
IS  - 0151-9638 (Linking)
VI  - 144
IP  - 12
DP  - 2017 Dec
TI  - [DRESS complicated by hemophagocytic lymphohistiocytosis in an infant treated for
      congenital toxoplasmosis].
PG  - 784-787
LID - S0151-9638(17)30243-0 [pii]
LID - 10.1016/j.annder.2017.06.004 [doi]
AB  - BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a
      severe disease that may be complicated by hemophagocytic lymphohistiocytosis but 
      this is rarely described in children. PATIENTS AND METHODS: We report the case of
      a 5-week old infant hospitalized in a pediatric intensive care unit for
      hemophagocytic lymphohistiocytosis with prolonged fever, splenomegaly, cytopenia,
      fibrinogen</=1.5g/L, ferritin>/=500mug/L, and soluble IL-2 receptor>/=2400U/mL.
      As a result of the presence of a diffuse skin rash, eosinophilia and multiple
      organ failure that started three weeks after the initiation of a congenital
      toxoplasmosis treatment, association with DRESS was suggested. DISCUSSION:
      Exposure to sulfadiazine remains the main factor leading to DRESS in this case.
      This is probably the trigger event, secondarily complicated by hemophagocytic
      lymphohistiocytosis, although in our case the diagnosis was made subsequently.
      The unfortunately poor outcome of this association is probably exacerbated in
      fragile patients such as young infants. CONCLUSION: Clinicians should be aware of
      the possibility of DRESS of every early onset associated with hemophagocytic
      lymphohistiocytosis linked to a treatment started during the neonatal period to
      avoid any delay in care that might adversely affect the prognosis.
CI  - Copyright (c) 2017 Elsevier Masson SAS. All rights reserved.
FAU - Rioualen, S
AU  - Rioualen S
AD  - Pole de la femme, de la mere et de l'enfant, centre hospitalier universitaire,
      02, avenue Foch, 29609 Brest, France; EA4685 (laboratoire de neurosciences de
      Brest), faculte de medecine et des sciences de la sante, universite de Bretagne
      Occidentale, 22, rue Camille-Desmoulins, 29200 Brest, France. Electronic address:
      stephane.rioualen@chu-brest.fr.
FAU - Dufau, J
AU  - Dufau J
AD  - Pole de la femme, de la mere et de l'enfant, centre hospitalier universitaire,
      02, avenue Foch, 29609 Brest, France.
FAU - Flatres, C
AU  - Flatres C
AD  - Pole de la femme, de la mere et de l'enfant, centre hospitalier universitaire,
      02, avenue Foch, 29609 Brest, France.
FAU - Lavenant, P
AU  - Lavenant P
AD  - Pole de la femme, de la mere et de l'enfant, centre hospitalier universitaire,
      02, avenue Foch, 29609 Brest, France.
FAU - Misery, L
AU  - Misery L
AD  - EA4685 (laboratoire de neurosciences de Brest), faculte de medecine et des
      sciences de la sante, universite de Bretagne Occidentale, 22, rue
      Camille-Desmoulins, 29200 Brest, France; Service de dermatologie, centre
      hospitalier universitaire, 2, avenue Foch, 29609 Brest, France.
FAU - Roue, J-M
AU  - Roue JM
AD  - Pole de la femme, de la mere et de l'enfant, centre hospitalier universitaire,
      02, avenue Foch, 29609 Brest, France; EA4685 (laboratoire de neurosciences de
      Brest), faculte de medecine et des sciences de la sante, universite de Bretagne
      Occidentale, 22, rue Camille-Desmoulins, 29200 Brest, France.
LA  - fre
PT  - English Abstract
PT  - Journal Article
TT  - DRESS complique d'un syndrome d'activation macrophagique chez un nourrisson
      traite pour une toxoplasmose congenitale.
DEP - 20170717
PL  - France
TA  - Ann Dermatol Venereol
JT  - Annales de dermatologie et de venereologie
JID - 7702013
OTO - NOTNLM
OT  - DRESS
OT  - Hemophagocytic lymphohistiocytosis
OT  - Infant
OT  - Nourrisson
OT  - Syndrome d'activation macrophagique
EDAT- 2017/07/22 06:00
MHDA- 2017/07/22 06:00
CRDT- 2017/07/22 06:00
PHST- 2016/12/13 00:00 [received]
PHST- 2017/02/16 00:00 [revised]
PHST- 2017/06/12 00:00 [accepted]
PHST- 2017/07/22 06:00 [pubmed]
PHST- 2017/07/22 06:00 [medline]
PHST- 2017/07/22 06:00 [entrez]
AID - S0151-9638(17)30243-0 [pii]
AID - 10.1016/j.annder.2017.06.004 [doi]
PST - ppublish
SO  - Ann Dermatol Venereol. 2017 Dec;144(12):784-787. doi:
      10.1016/j.annder.2017.06.004. Epub 2017 Jul 17.