PMID- 28720217
OWN - NLM
STAT- MEDLINE
DCOM- 20170926
LR  - 20180119
IS  - 1879-1883 (Electronic)
IS  - 0002-9610 (Linking)
VI  - 214
IP  - 4
DP  - 2017 Oct
TI  - Body mass index mediates the prognostic significance of circulating tumor cells
      in inflammatory breast cancer.
PG  - 666-671
LID - S0002-9610(17)30118-6 [pii]
LID - 10.1016/j.amjsurg.2017.06.005 [doi]
AB  - BACKGROUND: Obesity (BMI>/=30) may be an etiologic and prognostic factor in
      inflammatory breast cancer (IBC). We examined the relationship between BMI,
      pathologic complete response (pCR), and circulating-tumor-cell (CTC) levels in
      IBC. METHODS: Cohort included IBC patients diagnosed 2005-2015 who had
      neoadjuvant chemotherapy during a prospective trial on CTCs and pathologic review
      describing pCR. Chi-square, logistic regression, and Cox proportional hazards
      models were used to identify clinicopathologic associations with event-free
      survival (EFS). RESULTS: Of 73 patients, 61 (84%) had CTC values, 22 (30%)
      achieved a pCR, and 39 (53%) were obese. There was no difference between obese
      and non-obese patients for pCR rates (31% vs. 29%, p = 0.90) or presence of CTCs 
      (23% vs. 26%, p = 0.80). Among non-obese patients, CTCs were associated with
      worse EFS (HR 11.69, p < 0.01), but among obese patients, there was no difference
      in EFS between those with and without CTCs. CONCLUSIONS: BMI mediates CTCs'
      prognostic significance in IBC.
CI  - Copyright (c) 2017. Published by Elsevier Inc.
FAU - Fayanju, Oluwadamilola M
AU  - Fayanju OM
AD  - Division of Advanced Oncologic and GI Surgery, Department of Surgery, Duke
      University Medical Center, Durham, NC, USA. Electronic address:
      lola.fayanju@duke.edu.
FAU - Hall, Carolyn S
AU  - Hall CS
AD  - Department of Surgical Oncology, Division of Surgery, The University of Texas MD 
      Anderson Cancer Center, Houston, TX, USA. Electronic address:
      cshall@mdanderson.org.
FAU - Bauldry, Jessica Bowman
AU  - Bauldry JB
AD  - Department of Surgical Oncology, Division of Surgery, The University of Texas MD 
      Anderson Cancer Center, Houston, TX, USA. Electronic address:
      jbbauldry@mdanderson.org.
FAU - Karhade, Mandar
AU  - Karhade M
AD  - Department of Surgical Oncology, Division of Surgery, The University of Texas MD 
      Anderson Cancer Center, Houston, TX, USA. Electronic address:
      mkarhade@mdanderson.org.
FAU - Valad, Lily M
AU  - Valad LM
AD  - School of Medicine, University of Texas, Medical Branch, Galveston, TX, USA.
      Electronic address: lmvalad@utmb.edu.
FAU - Kuerer, Henry M
AU  - Kuerer HM
AD  - Department of Breast Surgical Oncology, Division of Surgery, The University of
      Texas MD Anderson Cancer Center, Houston, TX, USA; The Institute for Cancer Care 
      Innovation (ICCI), The University of Texas MD Anderson Cancer Center, Houston,
      TX, USA. Electronic address: hkuerer@mdanderson.org.
FAU - DeSnyder, Sarah M
AU  - DeSnyder SM
AD  - Department of Breast Surgical Oncology, Division of Surgery, The University of
      Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:
      sgainer@mdanderson.org.
FAU - Barcenas, Carlos H
AU  - Barcenas CH
AD  - Department of Breast Medical Oncology, Division of Cancer Medicine, The
      University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic
      address: chbarcenas@mdanderson.org.
FAU - Lucci, Anthony
AU  - Lucci A
AD  - Department of Breast Surgical Oncology, Division of Surgery, The University of
      Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Surgical
      Oncology, Division of Surgery, The University of Texas MD Anderson Cancer Center,
      Houston, TX, USA. Electronic address: alucci@mdanderson.org.
LA  - eng
GR  - KL2 TR001115/TR/NCATS NIH HHS/United States
GR  - P30 CA014236/CA/NCI NIH HHS/United States
PT  - Journal Article
DEP - 20170623
PL  - United States
TA  - Am J Surg
JT  - American journal of surgery
JID - 0370473
SB  - AIM
SB  - IM
MH  - Aged
MH  - *Body Mass Index
MH  - Female
MH  - Humans
MH  - Inflammatory Breast Neoplasms/*pathology/therapy
MH  - Middle Aged
MH  - Neoadjuvant Therapy
MH  - Neoplasm Staging
MH  - *Neoplastic Cells, Circulating
MH  - Obesity/*complications
MH  - Prognosis
MH  - Prospective Studies
MH  - Risk Factors
PMC - PMC5770232
MID - NIHMS930100
OTO - NOTNLM
OT  - Body mass index
OT  - Circulating tumor cells
OT  - Inflammatory breast cancer
OT  - Obesity
OT  - Pathologic complete response
OT  - Prognosis
EDAT- 2017/07/20 06:00
MHDA- 2017/09/28 06:00
CRDT- 2017/07/20 06:00
PHST- 2017/02/10 00:00 [received]
PHST- 2017/04/12 00:00 [revised]
PHST- 2017/06/18 00:00 [accepted]
PHST- 2017/07/20 06:00 [pubmed]
PHST- 2017/09/28 06:00 [medline]
PHST- 2017/07/20 06:00 [entrez]
AID - S0002-9610(17)30118-6 [pii]
AID - 10.1016/j.amjsurg.2017.06.005 [doi]
PST - ppublish
SO  - Am J Surg. 2017 Oct;214(4):666-671. doi: 10.1016/j.amjsurg.2017.06.005. Epub 2017
      Jun 23.