PMID- 28708810
DCOM- 20171013
LR  - 20180223
IS  - 1944-7884 (Electronic)
IS  - 1525-4135 (Linking)
VI  - 76
IP  - 3
DP  - 2017 Nov 1
TI  - Role of Normalized T-Cell Subsets in Predicting Comorbidities in a Large Cohort
      of Geriatric HIV-Infected Patients.
PG  - 338-342
LID - 10.1097/QAI.0000000000001496 [doi]
AB  - BACKGROUND: Adults aging with HIV are at greater risk for several comorbidities. 
      The CD4 cell count and CD4/CD8 ratio often fail to normalize in elderly patients 
      despite prolonged antiretroviral therapy; this has been associated with
      concomitant diseases and poor prognosis. METHODS: A cross-sectional analysis in
      antiretroviral-treated HIV-positive patients aged 65 years and older. The aim of 
      the study was to describe the predictors of normalized T-cell subsets ("nT",
      CD4/CD8 ratio >/=1 and CD4 >/=500 cells/muL) in a cohort of geriatric
      HIV-positive patients and its association with HIV-associated non-AIDS conditions
      (HANA). RESULTS: One thousand ninety-two patients were included: nT was observed 
      in 340 patients (31.1%). Multivariate binary logistic analysis showed that plasma
      HIV RNA <50 copies/mL (P = 0.004), female sex (P = 0.002), and nadir CD4 cell
      count (P < 0.001) were independent predictors of nT. Age and sex-adjusted
      prevalence of hypertension (P = 0.037), lipid abnormalities (P = 0.040), and
      multimorbidity (P = 0.034) were higher in subjects with nT, whereas chronic
      obstructive pulmonary disease (COPD) and cancer were lower (respectively, P =
      0.028 and P = 0.005). Multivariate analysis showed that HIV duration was an
      independent predictor of several comorbidities, whereas nT was protective for
      cancer and COPD. HIV duration and nT were simultaneously predictors of
      multimorbidity. CONCLUSIONS: Normalized T-cell subsets were observed in
      approximately one-third of geriatric HIV-positive subjects, and they were
      predicted by female sex and immunovirological features. HIV-associated non-AIDS
      conditions were more prevalent in patients with longer HIV duration, whereas nT
      represented a protective factor for cancer and COPD.
FAU - Calcagno, Andrea
AU  - Calcagno A
AD  - *Unit of Infectious Diseases, Department of Medical Sciences, University of
      Torino, Torino, Italy; dagger1st Division of Infectious Diseases Unit, University
      of Milano, Ospedale L. Sacco, Milano, Italy; double daggerDepartment of
      Infectious and Tropical Diseases, University of Brescia, Brescia, Italy; section 
      signDepartment of Infectious Diseases, San Raffaele Scientific Institute, Milano,
      Italy; ||Department of Mother, Child and Adult Medicine and Surgical Science,
      University of Modena and Reggio Emilia, Infectious Diseases Clinic, Modena,
      Italy; paragraph signUnit of Infectious Diseases, Department of Internal
      Medicine, Azienda Ospedaliero-Universitaria di Padova, Padova, Italy; #Unit of
      Infectious Diseases, "Divisione A", OspedaleAmedeo di Savoia, ASLTO2, Torino,
      Italy; **Department of Clinical and Molecular Biomedicine, Division of Infectious
      Diseases, University of Catania, ARNAS Garibaldi, Catania, Italy; daggerdagger3rd
      Division of Infectious Diseases, University of Milano, Ospedale L. Sacco, Milano,
      Italy; and double daggerdouble daggerDepartment of Infectious Diseases, Azienda
      Ospedaliero-Universitaria di Perugia, Perugia, Italy.
FAU - Piconi, Stefania
AU  - Piconi S
FAU - Foca, Emanuele
AU  - Foca E
FAU - Nozza, Silvia
AU  - Nozza S
FAU - Carli, Federica
AU  - Carli F
FAU - Montrucchio, Chiara
AU  - Montrucchio C
FAU - Cattelan, Annamaria M
AU  - Cattelan AM
FAU - Orofino, Giancarlo
AU  - Orofino G
FAU - Celesia, Benedetto M
AU  - Celesia BM
FAU - Morena, Valentina
AU  - Morena V
FAU - De Socio, Giuseppe V
AU  - De Socio GV
FAU - Guaraldi, Giovanni
AU  - Guaraldi G
CN  - GEPPO (GEriatric Patients living with HIV/AIDS: a Prospective Multidimensional
      cOhort) Study Group
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Acquir Immune Defic Syndr
JT  - Journal of acquired immune deficiency syndromes (1999)
JID - 100892005
RN  - 0 (Biomarkers)
RN  - 0 (RNA, Viral)
SB  - IM
SB  - X
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*immunology
MH  - Antiretroviral Therapy, Highly Active
MH  - Biomarkers/blood
MH  - CD4-CD8 Ratio
MH  - CD4-Positive T-Lymphocytes
MH  - CD8-Positive T-Lymphocytes
MH  - Comorbidity
MH  - Cross-Sectional Studies
MH  - Female
MH  - HIV Infections/drug therapy/*immunology/virology
MH  - Humans
MH  - Male
MH  - Multivariate Analysis
MH  - Predictive Value of Tests
MH  - RNA, Viral/analysis
MH  - Risk Factors
MH  - T-Lymphocyte Subsets
MH  - Viral Load
EDAT- 2017/07/15 06:00
MHDA- 2017/10/14 06:00
CRDT- 2017/07/15 06:00
PHST- 2017/07/15 06:00 [pubmed]
PHST- 2017/10/14 06:00 [medline]
PHST- 2017/07/15 06:00 [entrez]
AID - 10.1097/QAI.0000000000001496 [doi]
PST - ppublish
SO  - J Acquir Immune Defic Syndr. 2017 Nov 1;76(3):338-342. doi: