PMID- 28707316
OWN - NLM
STAT- MEDLINE
DCOM- 20190128
LR  - 20190128
IS  - 1522-726X (Electronic)
IS  - 1522-1946 (Linking)
VI  - 91
IP  - 1
DP  - 2018 Jan 1
TI  - TIcaGrEloR and Absorb bioresorbable vascular scaffold implantation for recovery
      of vascular function after successful chronic total occlusion recanalization
      (TIGER-BVS trial): Rationale and study design.
PG  - 1-6
LID - 10.1002/ccd.27196 [doi]
AB  - OBJECTIVES: To explore the role of ticagrelor versus clopidogrel in coronary
      blood flow normalization immediately after chronic coronary total occlusion (CTO)
      recanalization. BACKGROUND: Coronary vascular function of a CTO immediately after
      recanalization is demonstrated to be poor. METHODS: The TIGER BVS is a
      prospective, double-randomized, open-label, two parallel-group controlled
      clinical trial to evaluate efficacy of ticagrelor versus clopidogrel in improving
      vascular function of coronary segment distal to CTO immediately after CTO
      recanalization. A total of 50 patients who receive CTO PCI will be randomized 1:1
      to receive ticagrelor versus clopidogrel at least 3 days before the procedure.
      Immediately after CTO recanalization with Absorb BVS implantation, a specific
      study of vascular function under adenosine infusion will be performed. Patients
      will be therefore randomized 1:1 to receive angiographic follow-up with vascular 
      function and optical coherence tomography analyses at 1- or 3-year follow-up.
      This study is registered on ClinicalTrials.gov with number NCT02211066.
      CONCLUSIONS: The TIGER BVS trial will provide the first randomized comparison
      between ticagrelor versus clopidogrel in recovering vascular function in CTO
      patients. It will also provide important data on vascular restoration therapy of 
      Absorb BVS in this scenario.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Brugaletta, Salvatore
AU  - Brugaletta S
AUID- ORCID: 0000-0001-5845-1435
AD  - Cardiovascular Institute, Hospital Clinic, University of Barcelona, IDIBAPS,
      Barcelona, Spain.
FAU - Gomez-Lara, Josep
AU  - Gomez-Lara J
AD  - Heart Disease Institute, Bellvitge Universitari Hospital, Universitari of
      Barcelona, IDIBELL, Barcelona, Spain.
FAU - Caballero, Juan
AU  - Caballero J
AD  - Hospitales Universitarios San Cecilio y Virgen de las Nieves, Granada, Spain.
FAU - Ortega-Paz, Luis
AU  - Ortega-Paz L
AD  - Cardiovascular Institute, Hospital Clinic, University of Barcelona, IDIBAPS,
      Barcelona, Spain.
FAU - Teruel, Luis
AU  - Teruel L
AD  - Heart Disease Institute, Bellvitge Universitari Hospital, Universitari of
      Barcelona, IDIBELL, Barcelona, Spain.
FAU - Jimenez Fernandez, Miriam
AU  - Jimenez Fernandez M
AD  - Hospitales Universitarios San Cecilio y Virgen de las Nieves, Granada, Spain.
FAU - Romaguera, Rafael
AU  - Romaguera R
AD  - Heart Disease Institute, Bellvitge Universitari Hospital, Universitari of
      Barcelona, IDIBELL, Barcelona, Spain.
FAU - Alcalde Martinez, Vicente
AU  - Alcalde Martinez V
AD  - Hospitales Universitarios San Cecilio y Virgen de las Nieves, Granada, Spain.
FAU - Nato, Marcos
AU  - Nato M
AD  - Heart Disease Institute, Bellvitge Universitari Hospital, Universitari of
      Barcelona, IDIBELL, Barcelona, Spain.
FAU - Molina Navarro, Eduardo
AU  - Molina Navarro E
AD  - Hospitales Universitarios San Cecilio y Virgen de las Nieves, Granada, Spain.
FAU - Gomez-Hospital, Joan-Antoni
AU  - Gomez-Hospital JA
AD  - Heart Disease Institute, Bellvitge Universitari Hospital, Universitari of
      Barcelona, IDIBELL, Barcelona, Spain.
FAU - Correa Vilches, Concepcion
AU  - Correa Vilches C
AD  - Hospitales Universitarios San Cecilio y Virgen de las Nieves, Granada, Spain.
FAU - Joyera, Maria
AU  - Joyera M
AD  - Hospital Clinic, Barcelona, Spain.
FAU - Cequier, Angel
AU  - Cequier A
AD  - Heart Disease Institute, Bellvitge Universitari Hospital, Universitari of
      Barcelona, IDIBELL, Barcelona, Spain.
FAU - Sabate, Manel
AU  - Sabate M
AD  - Cardiovascular Institute, Hospital Clinic, University of Barcelona, IDIBAPS,
      Barcelona, Spain.
LA  - eng
SI  - ClinicalTrials.gov/NCT02211066
PT  - Clinical Trial Protocol
PT  - Journal Article
DEP - 20170714
PL  - United States
TA  - Catheter Cardiovasc Interv
JT  - Catheterization and cardiovascular interventions : official journal of the
      Society for Cardiac Angiography & Interventions
JID - 100884139
RN  - 0 (Platelet Aggregation Inhibitors)
RN  - A74586SNO7 (Clopidogrel)
RN  - GLH0314RVC (Ticagrelor)
SB  - IM
CIN - Catheter Cardiovasc Interv. 2018 Jan 1;91(1):7-8. PMID: 29314641
MH  - *Absorbable Implants
MH  - Chronic Disease
MH  - Clopidogrel/*administration & dosage/adverse effects
MH  - Coronary Angiography
MH  - Coronary Circulation/*drug effects
MH  - Coronary Occlusion/diagnostic imaging/physiopathology/*therapy
MH  - Female
MH  - Humans
MH  - Male
MH  - Multicenter Studies as Topic
MH  - Percutaneous Coronary Intervention/adverse effects/*instrumentation
MH  - Platelet Aggregation Inhibitors/*administration & dosage/adverse effects
MH  - Prospective Studies
MH  - Prosthesis Design
MH  - Randomized Controlled Trials as Topic
MH  - Recovery of Function
MH  - Ticagrelor/*administration & dosage/adverse effects
MH  - Time Factors
MH  - Treatment Outcome
OTO - NOTNLM
OT  - *antiplatelet therapy
OT  - *bioabsorbable stent
OT  - *coronary artery disease
EDAT- 2017/07/15 06:00
MHDA- 2019/01/29 06:00
CRDT- 2017/07/15 06:00
PHST- 2017/05/23 00:00 [received]
PHST- 2017/06/12 00:00 [accepted]
PHST- 2017/07/15 06:00 [pubmed]
PHST- 2019/01/29 06:00 [medline]
PHST- 2017/07/15 06:00 [entrez]
AID - 10.1002/ccd.27196 [doi]
PST - ppublish
SO  - Catheter Cardiovasc Interv. 2018 Jan 1;91(1):1-6. doi: 10.1002/ccd.27196. Epub
      2017 Jul 14.