PMID- 28701499
OWN - NLM
STAT- MEDLINE
DCOM- 20170822
LR  - 20181113
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 89
IP  - 6
DP  - 2017 Aug 8
TI  - Breastfeeding, ovulatory years, and risk of multiple sclerosis.
PG  - 563-569
LID - 10.1212/WNL.0000000000004207 [doi]
AB  - OBJECTIVE: To determine whether women who breastfeed their infants longer or have
      fewer ovulatory years are at lower risk of developing multiple sclerosis (MS).
      METHODS: We recruited women with newly diagnosed MS or its precursor, clinically 
      isolated syndrome (CIS) (n = 397), and matched controls (n = 433) into the MS
      Sunshine Study from the membership of Kaiser Permanente Southern California. A
      structured in-person questionnaire was administered to collect the behavioral
      (pregnancies, breastfeeding, hormonal contraceptive use) and biological (age at
      menarche and menopause, amenorrhea) factors to make up ovulatory years. RESULTS: 
      Among women who had live births, a cumulative duration of breastfeeding for >/=15
      months was associated with a reduced risk of MS/CIS (adjusted odds ratio [OR]
      0.47, 95% confidence interval [CI] 0.28-0.77; p = 0.003 compared to 0-4 months of
      breastfeeding). Being >/=15 years of age at menarche was also associated with a
      lower risk of MS/CIS (adjusted OR 0.56, 95% CI 0.33-0.96; p = 0.035). Total
      ovulatory years and the remaining factors that determine it, including gravidity,
      parity, episodes of amenorrhea, and hormonal contraceptive use, as well as age at
      first birth, showed no significant association with the risk of MS/CIS.
      CONCLUSIONS: Mothers who breastfeed longer may be at lower subsequent risk of
      developing multiple sclerosis. This is consistent with the other known maternal
      health benefits of breastfeeding and with our previous observation that women
      with MS who breastfeed exclusively are at lower risk of postpartum relapses.
CI  - (c) 2017 American Academy of Neurology.
FAU - Langer-Gould, Annette
AU  - Langer-Gould A
AD  - From the Department of Research and Evaluation (A.L.-G., J.S., E.G.G., S.H.,
      C.K., A.H.X.), Kaiser Permanente Southern California; Neurology Department
      (A.L.-G.), Southern California Permanente Medical Group, Los Angeles Medical
      Center; and Department of Neurology (K.H.), University of Bochum, Germany. S.
      Haraszti is currently with the Philadelphia College of Osteopathic Medicine, PA. 
      Annette.M.Langer-Gould@kp.org.
FAU - Smith, Jessica B
AU  - Smith JB
AD  - From the Department of Research and Evaluation (A.L.-G., J.S., E.G.G., S.H.,
      C.K., A.H.X.), Kaiser Permanente Southern California; Neurology Department
      (A.L.-G.), Southern California Permanente Medical Group, Los Angeles Medical
      Center; and Department of Neurology (K.H.), University of Bochum, Germany. S.
      Haraszti is currently with the Philadelphia College of Osteopathic Medicine, PA.
FAU - Hellwig, Kerstin
AU  - Hellwig K
AD  - From the Department of Research and Evaluation (A.L.-G., J.S., E.G.G., S.H.,
      C.K., A.H.X.), Kaiser Permanente Southern California; Neurology Department
      (A.L.-G.), Southern California Permanente Medical Group, Los Angeles Medical
      Center; and Department of Neurology (K.H.), University of Bochum, Germany. S.
      Haraszti is currently with the Philadelphia College of Osteopathic Medicine, PA.
FAU - Gonzales, Edlin
AU  - Gonzales E
AD  - From the Department of Research and Evaluation (A.L.-G., J.S., E.G.G., S.H.,
      C.K., A.H.X.), Kaiser Permanente Southern California; Neurology Department
      (A.L.-G.), Southern California Permanente Medical Group, Los Angeles Medical
      Center; and Department of Neurology (K.H.), University of Bochum, Germany. S.
      Haraszti is currently with the Philadelphia College of Osteopathic Medicine, PA.
FAU - Haraszti, Samantha
AU  - Haraszti S
AD  - From the Department of Research and Evaluation (A.L.-G., J.S., E.G.G., S.H.,
      C.K., A.H.X.), Kaiser Permanente Southern California; Neurology Department
      (A.L.-G.), Southern California Permanente Medical Group, Los Angeles Medical
      Center; and Department of Neurology (K.H.), University of Bochum, Germany. S.
      Haraszti is currently with the Philadelphia College of Osteopathic Medicine, PA.
FAU - Koebnick, Corinna
AU  - Koebnick C
AD  - From the Department of Research and Evaluation (A.L.-G., J.S., E.G.G., S.H.,
      C.K., A.H.X.), Kaiser Permanente Southern California; Neurology Department
      (A.L.-G.), Southern California Permanente Medical Group, Los Angeles Medical
      Center; and Department of Neurology (K.H.), University of Bochum, Germany. S.
      Haraszti is currently with the Philadelphia College of Osteopathic Medicine, PA.
FAU - Xiang, Anny
AU  - Xiang A
AD  - From the Department of Research and Evaluation (A.L.-G., J.S., E.G.G., S.H.,
      C.K., A.H.X.), Kaiser Permanente Southern California; Neurology Department
      (A.L.-G.), Southern California Permanente Medical Group, Los Angeles Medical
      Center; and Department of Neurology (K.H.), University of Bochum, Germany. S.
      Haraszti is currently with the Philadelphia College of Osteopathic Medicine, PA.
LA  - eng
GR  - R01 NS075308/NS/NINDS NIH HHS/United States
PT  - Journal Article
DEP - 20170712
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - AIM
SB  - IM
MH  - Adult
MH  - *Breast Feeding
MH  - California
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Multiple Sclerosis/*epidemiology/*physiopathology
MH  - Reproductive Physiological Phenomena
MH  - Risk
MH  - Socioeconomic Factors
MH  - Surveys and Questionnaires
MH  - Time Factors
PMC - PMC5562955
EDAT- 2017/07/14 06:00
MHDA- 2017/08/23 06:00
CRDT- 2017/07/14 06:00
PHST- 2016/12/02 00:00 [received]
PHST- 2017/05/18 00:00 [accepted]
PHST- 2017/07/14 06:00 [pubmed]
PHST- 2017/08/23 06:00 [medline]
PHST- 2017/07/14 06:00 [entrez]
AID - WNL.0000000000004207 [pii]
AID - 10.1212/WNL.0000000000004207 [doi]
PST - ppublish
SO  - Neurology. 2017 Aug 8;89(6):563-569. doi: 10.1212/WNL.0000000000004207. Epub 2017
      Jul 12.