PMID- 28692544
DCOM- 20180514
LR  - 20180613
IS  - 1473-5571 (Electronic)
IS  - 0269-9370 (Linking)
VI  - 31
IP  - 15
DP  - 2017 Sep 24
TI  - The effect of school attendance and school dropout on incident HIV and HSV-2
      among young women in rural South Africa enrolled in HPTN 068.
PG  - 2127-2134
LID - 10.1097/QAD.0000000000001584 [doi]
AB  - OBJECTIVE: To estimate the association between school attendance, school dropout,
      and risk of incident HIV and herpes simplex virus type 2 (HSV-2) infection among 
      young women. DESIGN: We used longitudinal data from a randomized controlled trial
      in rural Mpumalanga province, South Africa, to assess the association between
      school days attended, school dropout, and incident HIV and HSV-2 in young women
      aged 13-23 years. METHODS: We examined inverse probability of exposure weighted
      survival curves and used them to calculate 1.5, 2.5, and 3.5-year risk
      differences and risk ratios for the effect of school attendance on incident HIV
      and HSV-2. A marginal structural Cox model was used to estimate hazard ratios for
      the effect of school attendance and school dropout on incident infection.
      RESULTS: Risk of infection increased over time as young women aged, and was
      higher in young women with low school attendance (<80% school days) compared with
      high (>/=80% school days). Young women with low attendance were more likely to
      acquire HIV [hazard ratio (HR): 2.97; 95% confidence interval (CI): 1.62, 5.45]
      and HSV-2 (HR: 2.47; 95% CI: 1.46, 4.17) over the follow-up period than young
      women with high attendance. Similarly, young women who dropped out of school had 
      a higher weighted hazard of both HIV (HR 3.25 95% CI: 1.67, 6.32) and HSV-2 (HR
      2.70; 95% CI 1.59, 4.59). CONCLUSION: Young women who attend more school days and
      stay in school have a lower risk of incident HIV and HSV-2 infection.
      Interventions to increase frequency of school attendance and prevent dropout
      should be promoted to reduce risk of infection.
FAU - Stoner, Marie C D
AU  - Stoner MCD
AD  - aDepartment of Epidemiology, University of North Carolina, Chapel Hill, North
      Carolina, USA bMRC/Wits Rural Public Health and Health Transitions Research Unit 
      (Agincourt), Faculty of Health Sciences, School of Public Health, University of
      the Witwatersrand, Johannesburg, South Africa cDepartment of Maternal and Child
      Health, University of North Carolina, Chapel Hill, North Carolina, USA
      dEpidemiology and Global Health Unit, Department of Public Health and Clinical
      Medicine, Umea University, Umea, Sweden eDepartment of Biostatistics, University 
      of Washington fFred Hutchinson Cancer Research Center, Seattle, Washington
      gDepartment of Pathology, School of Medicine, Johns Hopkins University,
      Baltimore, Maryland, USA hINDEPTH Network, Accra, Ghana, West Africa iSchool of
      Health and Society, University of Wollongong, New South Wales, Australia jWits
      Reproductive Health and HIV Research Institute, University of the Witwatersrand, 
      Johannesburg, South Africa.
FAU - Pettifor, Audrey
AU  - Pettifor A
FAU - Edwards, Jessie K
AU  - Edwards JK
FAU - Aiello, Allison E
AU  - Aiello AE
FAU - Halpern, Carolyn T
AU  - Halpern CT
FAU - Julien, Aimee
AU  - Julien A
FAU - Selin, Amanda
AU  - Selin A
FAU - Twine, Rhian
AU  - Twine R
FAU - Hughes, James P
AU  - Hughes JP
FAU - Wang, Jing
AU  - Wang J
FAU - Agyei, Yaw
AU  - Agyei Y
FAU - Gomez-Olive, F Xavier
AU  - Gomez-Olive FX
FAU - Wagner, Ryan G
AU  - Wagner RG
FAU - MacPhail, Catherine
AU  - MacPhail C
FAU - Kahn, Kathleen
AU  - Kahn K
LA  - eng
GR  - UM1 AI069423/AI/NIAID NIH HHS/United States
GR  - T32 AI007001/AI/NIAID NIH HHS/United States
GR  - 085477/B/08/Z/Wellcome Trust/United Kingdom
GR  - 058893/Z/99/A/Wellcome Trust/United Kingdom
GR  - Medical Research Council/United Kingdom
GR  - R01 MH087118/MH/NIMH NIH HHS/United States
GR  - UM1 AI068619/AI/NIAID NIH HHS/United States
GR  - UM1 AI068613/AI/NIAID NIH HHS/United States
GR  - Wellcome Trust/United Kingdom
GR  - 085477/Z/08/Z/Wellcome Trust/United Kingdom
GR  - P2C HD050924/HD/NICHD NIH HHS/United States
GR  - 069683/Z/02/Z/Wellcome Trust/United Kingdom
GR  - P30 AI050410/AI/NIAID NIH HHS/United States
GR  - UM1 AI068617/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - England
JT  - AIDS (London, England)
JID - 8710219
SB  - IM
SB  - X
MH  - Adolescent
MH  - Child
MH  - Female
MH  - HIV Infections/*epidemiology
MH  - Herpes Genitalis/*epidemiology
MH  - Humans
MH  - Incidence
MH  - Longitudinal Studies
MH  - Risk Assessment
MH  - *Rural Population
MH  - South Africa/epidemiology
MH  - *Student Dropouts
MH  - Young Adult
PMC - PMC5599334
MID - NIHMS892028
EDAT- 2017/07/12 06:00
MHDA- 2018/05/15 06:00
CRDT- 2017/07/11 06:00
PMCR- 2018/09/24 00:00
PHST- 2018/09/24 00:00 [pmc-release]
PHST- 2017/07/12 06:00 [pubmed]
PHST- 2018/05/15 06:00 [medline]
PHST- 2017/07/11 06:00 [entrez]
AID - 10.1097/QAD.0000000000001584 [doi]
PST - ppublish
SO  - AIDS. 2017 Sep 24;31(15):2127-2134. doi: 10.1097/QAD.0000000000001584.