PMID- 28692536
DCOM- 20180514
LR  - 20180523
IS  - 1473-5571 (Electronic)
IS  - 0269-9370 (Linking)
VI  - 31
IP  - 15
DP  - 2017 Sep 24
TI  - Asymptomatic anorectal Chlamydia trachomatis and Neisseria gonorrhoeae infections
      are associated with systemic CD8+ T-cell activation.
PG  - 2069-2076
LID - 10.1097/QAD.0000000000001580 [doi]
AB  - BACKGROUND: Oral preexposure prophylaxis (PrEP) has been established as a pivotal
      strategy in HIV prevention. However, bacterial sexually transmitted infections
      (STIs), such as Chlamydia trachomatis and Neisseria gonorrhoeae, are also highly 
      prevalent. Although the presence of STI-related mucosal lesions is a known risk
      factor for HIV acquisition, the potential increase in risk associated with
      asymptomatic STIs is not completely understood. Recent data demonstrated higher
      T-cell activation is a risk factor for sexually acquired HIV-1 infection. We
      examined the effect of asymptomatic C. trachomatis and N. gonorrhoeae anorectal
      infection on systemic immune activation, potentially increasing the risk of HIV
      acquisition. METHODS: We analyzed samples from participants of PrEP Brasil, a
      demonstration study of daily oral emtricitabine/tenofovir disoproxil fumarate HIV
      PrEP among healthy MSM, for T-cell activation by flow cytometry. We included 34
      asymptomatic participants with anorectal swab for C. trachomatis and/or N.
      gonorrhoeae infection, whereas negative for other STIs, and 35 controls. RESULTS:
      We found a higher frequency of human leukocyte antigen DRCD38 CD8 T cells (1.5
      vs. 0.9%, P < 0.005) and with memory phenotype in the group with asymptomatic C. 
      trachomatis and/or N. gonorrhoeae infection. Exhaustion and senescence markers
      were also significant higher in this group. No difference was observed in the
      soluble CD14 levels. CONCLUSION: Our findings suggest asymptomatic anorectal C.
      trachomatis and/or N. gonorrhoeae increase systemic immune activation,
      potentially increasing the risk of HIV acquisition. Regular screening and
      treatment of asymptomatic STIs should be explored as adjuvant tools for HIV
FAU - Vieira, Vinicius A
AU  - Vieira VA
AD  - aDivision of Clinical Immunology and Allergy bDepartment of Infectious and
      Parasitic Diseases, University of Sao Paulo School of Medicine cInstituto de
      Ensino e Pesquisa, Hospital Sirio-Libanes dCentro de Referencia e Treinamento em 
      DST/AIDS, Sao Paulo, Sao Paulo eInstituto Nacional de Infectologia Evandro
      Chagas, Fundacao Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil.
FAU - Avelino-Silva, Vivian I
AU  - Avelino-Silva VI
FAU - Cerqueira, Natalia B
AU  - Cerqueira NB
FAU - Costa, Dayane A
AU  - Costa DA
FAU - Costa, Priscilla R
AU  - Costa PR
FAU - Vasconcelos, Ricardo P
AU  - Vasconcelos RP
FAU - Madruga, Valdez R
AU  - Madruga VR
FAU - Moreira, Ronaldo I
AU  - Moreira RI
FAU - Hoagland, Brenda
AU  - Hoagland B
FAU - Veloso, Valdilea G
AU  - Veloso VG
FAU - Grinsztejn, Beatriz
AU  - Grinsztejn B
FAU - Kallas, Esper G
AU  - Kallas EG
CN  - PrEP Brasil Study Team
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
JT  - AIDS (London, England)
JID - 8710219
RN  - 0 (CD8 Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Membrane Glycoproteins)
RN  - EC (CD38 protein, human)
RN  - EC (ADP-ribosyl Cyclase 1)
SB  - IM
SB  - X
MH  - ADP-ribosyl Cyclase 1/analysis
MH  - Adult
MH  - Asymptomatic Diseases
MH  - CD8 Antigens/analysis
MH  - CD8-Positive T-Lymphocytes/chemistry/*immunology
MH  - Chlamydia Infections/*pathology
MH  - Chlamydia trachomatis/isolation & purification
MH  - Cross-Sectional Studies
MH  - Flow Cytometry
MH  - Gonorrhea/*pathology
MH  - HLA-DR Antigens/analysis
MH  - Humans
MH  - *Lymphocyte Activation
MH  - Male
MH  - Membrane Glycoproteins/analysis
MH  - Neisseria gonorrhoeae/isolation & purification
MH  - Rectal Diseases/*pathology
MH  - Young Adult
EDAT- 2017/07/12 06:00
MHDA- 2018/05/15 06:00
CRDT- 2017/07/11 06:00
PHST- 2017/07/12 06:00 [pubmed]
PHST- 2018/05/15 06:00 [medline]
PHST- 2017/07/11 06:00 [entrez]
AID - 10.1097/QAD.0000000000001580 [doi]
PST - ppublish
SO  - AIDS. 2017 Sep 24;31(15):2069-2076. doi: 10.1097/QAD.0000000000001580.