PMID- 28691499
OWN - NLM
STAT- In-Data-Review
LR  - 20180309
IS  - 1931-8405 (Electronic)
IS  - 0889-2229 (Linking)
VI  - 34
IP  - 1
DP  - 2018 Jan
TI  - Eradication of HIV from Tissue Reservoirs: Challenges for the Cure.
PG  - 3-8
LID - 10.1089/AID.2017.0072 [doi]
AB  - The persistence of HIV infection, even after lengthy and successful combined
      antiretroviral therapy (cART), has precluded an effective cure. The anatomical
      locations and biological mechanisms through which the viral population is
      maintained remain unknown. Much research has focused nearly exclusively on
      circulating resting T cells as the predominant source of persistent HIV, a
      strategy with limited success in developing an effective cure strategy. In this
      study, we review research supporting the importance of anatomical tissues and
      other immune cells for HIV maintenance and expansion, including the central
      nervous system, lymph nodes, and macrophages. We present accumulated research
      that clearly demonstrates the limitations of using blood-derived cells as a proxy
      for tissue reservoirs and sanctuaries throughout the body. We cite recent studies
      that have successfully used deep-sequencing strategies to uncover the complexity 
      of HIV infection and the ability of the virus to evolve despite undetectable
      plasma viral loads. Finally, we suggest new strategies and highlight the
      importance of tissue banks for future research.
FAU - Rose, Rebecca
AU  - Rose R
AD  - 1 Bioinfoexperts LLC , Thibodaux, Louisiana.
FAU - Nolan, David J
AU  - Nolan DJ
AD  - 1 Bioinfoexperts LLC , Thibodaux, Louisiana.
FAU - Maidji, Ekaterina
AU  - Maidji E
AD  - 2 Division of Experimental Medicine, Department of Medicine, Zuckerberg San
      Francisco General Hospital, University of California , San Francisco, San
      Francisco, California.
FAU - Stoddart, Cheryl A
AU  - Stoddart CA
AD  - 2 Division of Experimental Medicine, Department of Medicine, Zuckerberg San
      Francisco General Hospital, University of California , San Francisco, San
      Francisco, California.
FAU - Singer, Elyse J
AU  - Singer EJ
AD  - 3 The National Neurological AIDS Bank at David Geffen School of Medicine,
      University of California at Los Angeles , Los Angeles, California.
AD  - 4 Department of Pathology and Laboratory Medicine, David Geffen School of
      Medicine and Olive View-UCLA Medical Center , Los Angeles, California.
FAU - Lamers, Susanna L
AU  - Lamers SL
AD  - 1 Bioinfoexperts LLC , Thibodaux, Louisiana.
FAU - McGrath, Michael S
AU  - McGrath MS
AD  - 5 The AIDS and Cancer Specimen Resource , San Francisco, California.
AD  - 6 Department of Laboratory Medicine, University of California , San Francisco,
      San Francisco, California.
LA  - eng
GR  - R01 MH100984/MH/NIMH NIH HHS/United States
GR  - U24 MH100925/MH/NIMH NIH HHS/United States
PT  - Journal Article
DEP - 20170807
PL  - United States
TA  - AIDS Res Hum Retroviruses
JT  - AIDS research and human retroviruses
JID - 8709376
PMC - PMC5771544
OTO - NOTNLM
OT  - cART
OT  - compartment
OT  - cure
OT  - evolution
OT  - persistence
OT  - replication
EDAT- 2017/07/12 06:00
MHDA- 2017/07/12 06:00
CRDT- 2017/07/11 06:00
PMCR- 2019/01/01 00:00
PHST- 2019/01/01 00:00 [pmc-release]
PHST- 2017/07/12 06:00 [pubmed]
PHST- 2017/07/12 06:00 [medline]
PHST- 2017/07/11 06:00 [entrez]
AID - 10.1089/AID.2017.0072 [doi]
PST - ppublish
SO  - AIDS Res Hum Retroviruses. 2018 Jan;34(1):3-8. doi: 10.1089/AID.2017.0072. Epub
      2017 Aug 7.