PMID- 28686649
OWN - NLM
STAT- MEDLINE
DCOM- 20170927
LR  - 20180813
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 7
DP  - 2017
TI  - Survey on the levels of 25-hydroxy vitamin D and bone metabolic markers and
      evaluation of their correlations with osteoporosis in perimenopausal woman in
      Xi'an region.
PG  - e0180366
LID - 10.1371/journal.pone.0180366 [doi]
AB  - It has been accepted that vitamin D (VD) plays an important role in bone
      metabolism. However, the levels of VD in people of different regions are quite
      different and there is still no final conclusion on the significant correlation
      between VD and osteoporosis. 245 cases of peri-menopausal women were collected to
      study the relationship between VD and osteoporosis in western China. The mean
      value of 25-hydroxyvitamin D for the participants was 14.39 ng/mL. The average
      values of parathyroid hormone (PTH), calcium (Ca) and phosphorus (P) were 47.62
      pg/mL, 2.26 mmol/L and 1.18 mmol/L, respectively. The average value of bone
      mineral density (BMD) in lumbar vertebrae was -1.20 SD and that in femoral neck
      was -0.04 SD. Compared with normal group, PTH of VD deficiency group was
      significantly increased (P < 0.05), Ca was remarkably decreased (P < 0.01) while 
      the BMD between these two groups showed no significant difference (P > 0.05). VD 
      was in positive correlation with the age (P < 0.01) and Ca (< 0.01) of the
      participants, negative correlation with PTH (P < 0.01) while no significant
      correlation with the BMD of lumbar vertebrae and femoral neck (P > 0.05). The
      risk factors resulting in the occurrence of osteoporosis in the lumbar vertebrae 
      of the participants covered Ca increase (OR = 66.247, P<0.05), age growth (OR =
      1.194, P<0.01) and menopause (OR = 2.285, P<0.05). This study has found that the 
      status of VD deficiency showed no significant correlation with the level of BMD, 
      which hinted that independent measurement of the bone metabolic markers,
      including Ca, P, VD and PTH, was difficult to accurately reflect the status of
      BMD in peri-menopausal women of this region. It's necessary to combine multi-site
      bone scanning to diagnose the patients' status of osteoporosis so as to provide
      reasonable guidance for early clinical prevention and treatment.
FAU - Zhou, Ping
AU  - Zhou P
AD  - The Laboratory Department of Xi'an Jiaotong University Medical College First
      Affiliated Hospital, Xi'an, Shaanxi, China.
FAU - Hu, Jian
AU  - Hu J
AD  - The Laboratory Department of Xi'an Jiaotong University Medical College First
      Affiliated Hospital, Xi'an, Shaanxi, China.
FAU - Xi, Ping
AU  - Xi P
AD  - The Endocrinology Department of Xi'an Jiaotong University Medical College First
      Affiliated Hospital, Xi'an, Shaanxi, China.
FAU - Zhang, Ning
AU  - Zhang N
AD  - The Laboratory Department of Xi'an Jiaotong University Medical College First
      Affiliated Hospital, Xi'an, Shaanxi, China.
FAU - Yang, Bo
AU  - Yang B
AD  - The Laboratory Department of Xi'an Jiaotong University Medical College First
      Affiliated Hospital, Xi'an, Shaanxi, China.
FAU - Zheng, Jie
AU  - Zheng J
AD  - The Clinical Research Center of Xi'an Jiaotong University Medical College First
      Affiliated Hospital, Xi'an, Shaanxi, China.
FAU - Wang, Xiaoqin
AU  - Wang X
AD  - The Laboratory Department of Xi'an Jiaotong University Medical College First
      Affiliated Hospital, Xi'an, Shaanxi, China.
LA  - eng
PT  - Journal Article
DEP - 20170707
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Parathyroid Hormone)
RN  - 1406-16-2 (Vitamin D)
RN  - 27YLU75U4W (Phosphorus)
RN  - A288AR3C9H (25-hydroxyvitamin D)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Absorptiometry, Photon
MH  - Adult
MH  - Bone Density
MH  - Calcium/blood
MH  - Case-Control Studies
MH  - China
MH  - Female
MH  - Femur Neck/diagnostic imaging/pathology
MH  - Health Surveys
MH  - Humans
MH  - Lumbar Vertebrae/diagnostic imaging/pathology
MH  - Middle Aged
MH  - Osteoporosis/*blood/diagnostic imaging/pathology
MH  - Parathyroid Hormone/blood
MH  - Perimenopause/*blood
MH  - Phosphorus/blood
MH  - Retrospective Studies
MH  - Vitamin D/analogs & derivatives/blood
MH  - Vitamin D Deficiency/*blood/diagnosis/physiopathology
PMC - PMC5501542
EDAT- 2017/07/08 06:00
MHDA- 2017/09/28 06:00
CRDT- 2017/07/08 06:00
PHST- 2016/12/27 00:00 [received]
PHST- 2017/06/14 00:00 [accepted]
PHST- 2017/07/08 06:00 [entrez]
PHST- 2017/07/08 06:00 [pubmed]
PHST- 2017/09/28 06:00 [medline]
AID - 10.1371/journal.pone.0180366 [doi]
AID - PONE-D-16-51014 [pii]
PST - epublish
SO  - PLoS One. 2017 Jul 7;12(7):e0180366. doi: 10.1371/journal.pone.0180366.
      eCollection 2017.