PMID- 28619842
OWN - NLM
STAT- MEDLINE
DCOM- 20180209
LR  - 20180209
IS  - 1936-959X (Electronic)
IS  - 0195-6108 (Linking)
VI  - 38
IP  - 8
DP  - 2017 Aug
TI  - Cumulative Dose of Macrocyclic Gadolinium-Based Contrast Agent Improves Detection
      of Enhancing Lesions in Patients with Multiple Sclerosis.
PG  - 1486-1493
LID - 10.3174/ajnr.A5253 [doi]
AB  - BACKGROUND AND PURPOSE: Gadolinium-enhanced MR imaging is currently the reference
      standard for detecting active inflammatory lesions in patients with multiple
      sclerosis. The sensitivity of MR imaging for this purpose may vary according to
      the physicochemical characteristics of the contrast agent used and the
      acquisition strategy. The purpose of this study was to compare detection of
      gadolinium-enhancing lesions or active disease following a single or cumulative
      dose of a macrocyclic gadolinium-based contrast agent with different image
      acquisition delays in patients with clinically isolated syndrome or relapsing
      multiple sclerosis. MATERIALS AND METHODS: All patients received a first dose
      (0.1 mmol/kg) of gadobutrol and, 20 minutes later, a second dose (0.1 mmol/kg),
      with a cumulative dose of 0.2 mmol/kg. Two contrast-enhanced T1-weighted
      sequences were performed at 5 and 15 minutes after the first contrast
      administration, and 2 additional T1-weighted sequences at 5 and 15 minutes after 
      the second contrast administration with a 3T magnet. RESULTS: One hundred fifteen
      patients were considered evaluable. A significantly larger number of lesions were
      detected in scans obtained at 5 and 15 minutes after the second contrast
      injection compared with scans obtained at 5 and 15 minutes after the first
      injection (P < .001). The number of patients with active lesions on MR imaging
      was significantly higher after the second dose administration (52.0%, first dose 
      versus 59.2%, second dose; P < .001). CONCLUSIONS: Cumulative dosing of a
      macrocyclic gadolinium-based contrast agent increases detection of enhancing
      lesions and patients with active lesions. These data could be considered in the
      design of MR imaging protocols aimed at detecting active multiple sclerosis
      lesions.
CI  - (c) 2017 by American Journal of Neuroradiology.
FAU - Rovira, A
AU  - Rovira A
AUID- ORCID: http://orcid.org/0000-0002-2132-6750
AD  - From the Neuroradiology and Magnetic Resonance Units (A.R., C.A., E.H., J.F.C.,
      R.M.), Department of Radiology alex.rovira@idi.gencat.cat.
FAU - Auger, C
AU  - Auger C
AUID- ORCID: http://orcid.org/0000-0001-9846-4767
AD  - From the Neuroradiology and Magnetic Resonance Units (A.R., C.A., E.H., J.F.C.,
      R.M.), Department of Radiology.
FAU - Huerga, E
AU  - Huerga E
AUID- ORCID: http://orcid.org/0000-0002-6264-451X
AD  - From the Neuroradiology and Magnetic Resonance Units (A.R., C.A., E.H., J.F.C.,
      R.M.), Department of Radiology.
FAU - Corral, J F
AU  - Corral JF
AUID- ORCID: http://orcid.org/0000-0002-8699-4186
AD  - From the Neuroradiology and Magnetic Resonance Units (A.R., C.A., E.H., J.F.C.,
      R.M.), Department of Radiology.
FAU - Mitjana, R
AU  - Mitjana R
AUID- ORCID: http://orcid.org/0000-0002-2076-9461
AD  - From the Neuroradiology and Magnetic Resonance Units (A.R., C.A., E.H., J.F.C.,
      R.M.), Department of Radiology.
FAU - Sastre-Garriga, J
AU  - Sastre-Garriga J
AUID- ORCID: http://orcid.org/0000-0002-1589-2254
AD  - Centre d'Esclerosi Multiple de Catalunya (J.S.-G., M.T., X.M.), Department of
      Neurology/Neuroimmunology, Hospital Universitari Vall d'Hebron, Universitat
      Autonoma de Barcelona, Barcelona, Spain.
FAU - Tintore, M
AU  - Tintore M
AUID- ORCID: http://orcid.org/0000-0001-9999-5359
AD  - Centre d'Esclerosi Multiple de Catalunya (J.S.-G., M.T., X.M.), Department of
      Neurology/Neuroimmunology, Hospital Universitari Vall d'Hebron, Universitat
      Autonoma de Barcelona, Barcelona, Spain.
FAU - Montalban, X
AU  - Montalban X
AUID- ORCID: http://orcid.org/0000-0002-0098-9918
AD  - Centre d'Esclerosi Multiple de Catalunya (J.S.-G., M.T., X.M.), Department of
      Neurology/Neuroimmunology, Hospital Universitari Vall d'Hebron, Universitat
      Autonoma de Barcelona, Barcelona, Spain.
LA  - eng
PT  - Journal Article
DEP - 20170615
PL  - United States
TA  - AJNR Am J Neuroradiol
JT  - AJNR. American journal of neuroradiology
JID - 8003708
RN  - 0 (Contrast Media)
RN  - 0 (Organometallic Compounds)
RN  - 1BJ477IO2L (gadobutrol)
SB  - IM
MH  - Adult
MH  - Contrast Media/*administration & dosage
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Humans
MH  - Image Enhancement/*methods
MH  - Magnetic Resonance Imaging/*methods
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*diagnostic imaging/pathology
MH  - Organometallic Compounds/*administration & dosage
EDAT- 2017/06/18 06:00
MHDA- 2018/02/10 06:00
CRDT- 2017/06/17 06:00
PHST- 2016/12/29 00:00 [received]
PHST- 2017/04/02 00:00 [accepted]
PHST- 2017/06/18 06:00 [pubmed]
PHST- 2018/02/10 06:00 [medline]
PHST- 2017/06/17 06:00 [entrez]
AID - ajnr.A5253 [pii]
AID - 10.3174/ajnr.A5253 [doi]
PST - ppublish
SO  - AJNR Am J Neuroradiol. 2017 Aug;38(8):1486-1493. doi: 10.3174/ajnr.A5253. Epub
      2017 Jun 15.