PMID- 28609366
OWN - NLM
STAT- MEDLINE
DCOM- 20180410
LR  - 20180803
IS  - 1536-4828 (Electronic)
IS  - 0885-3177 (Linking)
VI  - 46
IP  - 6
DP  - 2017 Jul
TI  - Visceral Adiposity Predicts Severity of Acute Pancreatitis.
PG  - 776-781
LID - 10.1097/MPA.0000000000000845 [doi]
AB  - OBJECTIVES: The aim of this study was to determine the association of visceral
      adiposity with severe outcomes in acute pancreatitis (AP). METHODS: This
      retrospective study included consecutive patients with AP admitted to a tertiary 
      care hospital between January 2010 and January 2015 who underwent a computed
      tomography scan. The visceral adipose tissue (VAT) volume was estimated using the
      method of Linder and colleagues. Multivariable logistic regression analysis was
      conducted to assess VAT as a predictor of severe AP compared with other validated
      predictors of severity. RESULTS: Five hundred and seventy four patients were
      admitted during the study period, of which 252 had a computed tomography scan
      available. Patients with severe AP had a larger VAT area compared with those with
      mild or moderate AP (mean: 184.9 cm vs 79.9 cm, P = 0.006). Patients who
      developed multisystem organ failure or had acute necrotic collections had a
      larger VAT area than those who did not (150.6 cm vs 91.0 cm, P = 0.004 and 174.0 
      cm vs 91.9 cm, P = 0.003, respectively). Visceral adipose tissue area
      demonstrated superior discrimination of severe AP compared with other severity
      predictors. CONCLUSIONS: Increased VAT area is a strong predictor of severe
      pancreatitis, necrosis, and multisystem organ failure.
FAU - Natu, Ashwinee
AU  - Natu A
AD  - From the *Department of Internal Medicine, University Hospitals Cleveland Medical
      Center; daggerDepartment of Gastroenterology, Digestive Disease Institute,
      Cleveland Clinic; double daggerCase Western Reserve University School of
      Medicine; section signDepartment of Quantitative Health Sciences, Cleveland
      Clinic; parallelDepartment of Gastroenterology, Digestive Disease Institute,
      University Hospitals Cleveland Medical Center; paragraph signDepartment of
      Abdominal Imaging, Imaging Institute, Cleveland Clinic; #Department of Radiology,
      University Hospitals Cleveland Medical Center, Cleveland, OH.
FAU - Stevens, Tyler
AU  - Stevens T
FAU - Kang, Lorna
AU  - Kang L
FAU - Yasinow, Scott
AU  - Yasinow S
FAU - Mansoor, Emad
AU  - Mansoor E
FAU - Lopez, Rocio
AU  - Lopez R
FAU - Glessing, Brooke
AU  - Glessing B
FAU - Remer, Erick
AU  - Remer E
FAU - Richards, Tyler
AU  - Richards T
FAU - Gupta, Amit
AU  - Gupta A
FAU - Chak, Amitabh
AU  - Chak A
FAU - Lee, Peter J W
AU  - Lee PJW
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Pancreas
JT  - Pancreas
JID - 8608542
SB  - IM
MH  - Acute Disease
MH  - *Adiposity
MH  - Adult
MH  - Aged
MH  - Area Under Curve
MH  - Female
MH  - Humans
MH  - Intra-Abdominal Fat/diagnostic imaging/*physiopathology
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multiple Organ Failure/etiology
MH  - Multivariate Analysis
MH  - Pancreatitis/complications/diagnostic imaging/*physiopathology
MH  - Prognosis
MH  - ROC Curve
MH  - Reproducibility of Results
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Tomography, X-Ray Computed
EDAT- 2017/06/14 06:00
MHDA- 2018/04/11 06:00
CRDT- 2017/06/14 06:00
PHST- 2017/06/14 06:00 [entrez]
PHST- 2017/06/14 06:00 [pubmed]
PHST- 2018/04/11 06:00 [medline]
AID - 10.1097/MPA.0000000000000845 [doi]
AID - 00006676-201707000-00011 [pii]
PST - ppublish
SO  - Pancreas. 2017 Jul;46(6):776-781. doi: 10.1097/MPA.0000000000000845.