PMID- 28604838
OWN - NLM
STAT- MEDLINE
DCOM- 20170926
LR  - 20170926
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 6
DP  - 2017
TI  - Effect of acute pancreatitis on the risk of developing osteoporosis: A nationwide
      cohort study.
PG  - e0179358
LID - 10.1371/journal.pone.0179358 [doi]
AB  - PURPOSE: Chronic exocrine pancreatic insufficiency can lead to osteoporosis.
      However, the incidence and risk of osteoporosis after acute inflammation of
      pancreas remained known. Thus, we conducted a population-based cohort study to
      clarify the association between acute pancreatitis (AP) and osteoporosis.
      METHODS: Patients newly diagnosed with AP with index date between 2000 and 2011
      were identified from the National Health Insurance Research Database.
      Osteoporosis were defined according to the International Classification of
      Diseases, Ninth Revision, Clinical Modification codes. We applied age-, sex-, and
      comorbidities-adjusted variable Cox proportional hazard models for assessing the 
      association between AP and osteoporosis. Moreover, these models were used to
      adjust for the influences of patient characteristics and comorbidities. RESULTS: 
      In this study, 4,016 patients were included in the AP cohort (males, 67.9%; mean 
      age, 51.8 years) and 4,016 matched controls in the non-AP cohort. After a mean
      follow-up period of 4.97 and 5.21 years in the AP and non-AP cohorts,
      respectively, the incidence of osteoporosis was 8.22 per 1000 person-years in the
      AP cohort. The AP cohort had a higher risk [adjusted hazard ratio (aHR) = 1.27,
      95% confidence interval (CI) = 1.02-1.58] of osteoporosis than did the non-AP
      cohort. The risk of osteoporosis was highest in the female patients of the AP
      cohort (aHR = 2.26, 95% CI = 1.85-2.76) and patients aged 50-64 years (aHR =
      4.14, 95% CI = 3.13-5.47). CONCLUSION: AP patients are at a risk of osteoporosis,
      especially female gender and age 50-64 years. Those with > 3 episodes of AP had
      highest significant risk of developing osteoporosis.
FAU - Lin, Shih-Yi
AU  - Lin SY
AD  - Graduate Institute of Clinical Medical Science, College of Medicine, China
      Medical University, Taichung, Taiwan.
AD  - Division of Nephrology and Kidney Institute, China Medical University Hospital,
      Taichung, Taiwan.
FAU - Hsu, Wu-Huei
AU  - Hsu WH
AD  - Graduate Institute of Clinical Medical Science, College of Medicine, China
      Medical University, Taichung, Taiwan.
AD  - Department of Chest, China Medical University Hospital, Taichung, Taiwan.
FAU - Lin, Cheng-Chieh
AU  - Lin CC
AD  - Graduate Institute of Clinical Medical Science, College of Medicine, China
      Medical University, Taichung, Taiwan.
AD  - Department of Family Medicine, China Medical University Hospital, Taichung,
      Taiwan.
FAU - Lin, Cheng-Li
AU  - Lin CL
AD  - Management Office for Health Data, China Medical University Hospital, Taichung,
      Taiwan.
AD  - College of Medicine, China Medical University, Taichung, Taiwan.
FAU - Tsai, Chung-Hao
AU  - Tsai CH
AD  - Department of Orthopedics, China Medical University Hospital, Taichung, Taiwan.
FAU - Kao, Chia-Hung
AU  - Kao CH
AUID- ORCID: http://orcid.org/0000-0002-6368-3676
AD  - Graduate Institute of Clinical Medical Science, College of Medicine, China
      Medical University, Taichung, Taiwan.
AD  - Department of Nuclear Medicine and PET Center, China Medical University Hospital,
      Taichung, Taiwan.
AD  - Department of Bioinformatics and Medical Engineering, Asia University, Taichung, 
      Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20170612
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Acute Disease
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Comorbidity
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Osteoporosis/*epidemiology/*etiology
MH  - Pancreatitis/*complications/*epidemiology
MH  - Population Surveillance
MH  - Probability
MH  - Proportional Hazards Models
MH  - Risk
PMC - PMC5467899
EDAT- 2017/06/13 06:00
MHDA- 2017/09/28 06:00
CRDT- 2017/06/13 06:00
PHST- 2017/02/06 00:00 [received]
PHST- 2017/05/27 00:00 [accepted]
PHST- 2017/06/13 06:00 [entrez]
PHST- 2017/06/13 06:00 [pubmed]
PHST- 2017/09/28 06:00 [medline]
AID - 10.1371/journal.pone.0179358 [doi]
AID - PONE-D-17-04883 [pii]
PST - epublish
SO  - PLoS One. 2017 Jun 12;12(6):e0179358. doi: 10.1371/journal.pone.0179358.
      eCollection 2017.