PMID- 28601288
OWN - NLM
STAT- MEDLINE
DCOM- 20170821
LR  - 20190124
IS  - 1872-8421 (Electronic)
IS  - 0165-5728 (Linking)
VI  - 309
DP  - 2017 Aug 15
TI  - Autoantibodies as diagnostic biomarkers for the detection and subtyping of
      multiple sclerosis.
PG  - 51-57
LID - S0165-5728(17)30140-6 [pii]
LID - 10.1016/j.jneuroim.2017.05.010 [doi]
AB  - The goal of this preliminary proof-of-concept study was to use human protein
      microarrays to identify blood-based autoantibody biomarkers capable of diagnosing
      multiple sclerosis (MS). Using sera from 112 subjects, including 51 MS subjects, 
      autoantibody biomarkers effectively differentiated MS subjects from age- and
      gender-matched normal and breast cancer controls with 95.0% and 100% overall
      accuracy, but not from subjects with Parkinson's disease. Autoantibody biomarkers
      were also useful in distinguishing subjects with the relapsing-remitting form of 
      MS from those with the secondary progressive subtype. These results demonstrate
      that autoantibodies can be used as noninvasive blood-based biomarkers for the
      detection and subtyping of MS.
CI  - Copyright (c) 2017 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - DeMarshall, Cassandra
AU  - DeMarshall C
AD  - Biomarker Discovery Center, New Jersey Institute for Successful Aging, Rowan
      University School of Osteopathic Medicine, Stratford, NJ, USA; Department of
      Geriatrics and Gerontology, Rowan University School of Osteopathic Medicine,
      Stratford, NJ, USA.
FAU - Goldwaser, Eric L
AU  - Goldwaser EL
AD  - Biomarker Discovery Center, New Jersey Institute for Successful Aging, Rowan
      University School of Osteopathic Medicine, Stratford, NJ, USA; Department of
      Geriatrics and Gerontology, Rowan University School of Osteopathic Medicine,
      Stratford, NJ, USA.
FAU - Sarkar, Abhirup
AU  - Sarkar A
AD  - Biomarker Discovery Center, New Jersey Institute for Successful Aging, Rowan
      University School of Osteopathic Medicine, Stratford, NJ, USA; Department of
      Geriatrics and Gerontology, Rowan University School of Osteopathic Medicine,
      Stratford, NJ, USA; Graduate School of Biomedical Sciences, Rowan University,
      Stratford, NJ, USA.
FAU - Godsey, George A
AU  - Godsey GA
AD  - Biomarker Discovery Center, New Jersey Institute for Successful Aging, Rowan
      University School of Osteopathic Medicine, Stratford, NJ, USA; Department of
      Geriatrics and Gerontology, Rowan University School of Osteopathic Medicine,
      Stratford, NJ, USA; Graduate School of Biomedical Sciences, Rowan University,
      Stratford, NJ, USA.
FAU - Acharya, Nimish K
AU  - Acharya NK
AD  - Department of Neurosurgery, Penn Center for Brain Injury and Repair, Perelman
      School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
FAU - Thayasivam, Umashanger
AU  - Thayasivam U
AD  - Department of Mathematics, Rowan University, Glassboro, NJ, USA.
FAU - Belinka, Benjamin A
AU  - Belinka BA
AD  - Durin Technologies, Inc., New Brunswick, NJ, USA.
FAU - Nagele, Robert G
AU  - Nagele RG
AD  - Biomarker Discovery Center, New Jersey Institute for Successful Aging, Rowan
      University School of Osteopathic Medicine, Stratford, NJ, USA; Graduate School of
      Biomedical Sciences, Rowan University, Stratford, NJ, USA; Durin Technologies,
      Inc., New Brunswick, NJ, USA. Electronic address: nagelero@rowan.edu.
LA  - eng
PT  - Journal Article
DEP - 20170519
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Autoantibodies/*metabolism
MH  - Biomarkers/blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis, Chronic Progressive/*blood/*diagnosis
MH  - Multiple Sclerosis, Relapsing-Remitting/*blood/*diagnosis
MH  - Random Allocation
OTO - NOTNLM
OT  - *Autoantibodies
OT  - *Biomarkers
OT  - *Blood biomarkers
OT  - *Diagnostics
OT  - *Microarray
OT  - *Multiple sclerosis
EDAT- 2017/06/12 06:00
MHDA- 2017/08/22 06:00
CRDT- 2017/06/12 06:00
PHST- 2017/04/07 00:00 [received]
PHST- 2017/05/18 00:00 [revised]
PHST- 2017/05/18 00:00 [accepted]
PHST- 2017/06/12 06:00 [entrez]
PHST- 2017/06/12 06:00 [pubmed]
PHST- 2017/08/22 06:00 [medline]
AID - S0165-5728(17)30140-6 [pii]
AID - 10.1016/j.jneuroim.2017.05.010 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2017 Aug 15;309:51-57. doi: 10.1016/j.jneuroim.2017.05.010. Epub 
      2017 May 19.