PMID- 28593747
OWN - NLM
STAT- MEDLINE
DCOM- 20180709
LR  - 20180709
IS  - 1346-8138 (Electronic)
IS  - 0385-2407 (Linking)
VI  - 44
IP  - 11
DP  - 2017 Nov
TI  - Novel serum metabolomics-based approach by gas chromatography/triple quadrupole
      mass spectrometry for detection of human skin cancers: Candidate biomarkers.
PG  - 1268-1275
LID - 10.1111/1346-8138.13921 [doi]
AB  - Skin cancer incidence rates are continuing to rise; however, if detected at an
      early stage, they can be cured with minimally invasive treatment. Therefore, the 
      identification of novel and robust biomarkers for the early detection of skin
      cancer is required to improve the quality of life of the patient after treatment.
      In the present study, we aimed to identify novel biomarkers of skin cancers. We
      carried out serum metabolomics using gas chromatography/triple quadrupole mass
      spectrometry for two types of skin cancer: squamous cell carcinoma and melanoma. 
      The changes in the expression of metabolites compared with healthy volunteers
      were analyzed by principal component analysis. Among all 118 metabolites, 27 in
      patients with squamous cell carcinoma and 33 in patients with melanoma showed
      significant changes in comparison with healthy volunteers. Principal component
      analysis showed that both skin cancer groups could be distinguished from the
      healthy volunteers group. We further investigated the specific metabolites most
      useful for these distinctions. In the squamous cell carcinoma group, these
      metabolites were glycerol, 4-hydroxybenzoic acid, sebacic acid, fucose and
      suberic acid. In the melanoma group, these metabolites were glutamic acid,
      sebacic acid, suberic acid, 4-hydroxybenzoic acid and phenylalanine. The present 
      study identified several metabolites that were distinct for certain skin cancer
      types, which could potentially be used as diagnostic biomarkers leading to novel 
      clinical management strategies.
CI  - (c) 2017 Japanese Dermatological Association.
FAU - Fukumoto, Takeshi
AU  - Fukumoto T
AUID- ORCID: http://orcid.org/0000-0003-0364-711X
AD  - Division of Dermatology, Department of Internal Related, Kobe, Japan.
FAU - Nishiumi, Shin
AU  - Nishiumi S
AD  - Division of Gastroenterology, Kobe, Japan.
FAU - Fujiwara, Susumu
AU  - Fujiwara S
AD  - Division of Dermatology, Department of Internal Related, Kobe, Japan.
FAU - Yoshida, Masaru
AU  - Yoshida M
AD  - Division of Gastroenterology, Kobe, Japan.
AD  - Division of Metabolomics Research, Kobe University Graduate School of Medicine,
      Kobe, Japan.
AD  - AMED-CREST, AMED, Kobe, Japan.
FAU - Nishigori, Chikako
AU  - Nishigori C
AUID- ORCID: http://orcid.org/0000-0002-6784-2849
AD  - Division of Dermatology, Department of Internal Related, Kobe, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170608
PL  - England
TA  - J Dermatol
JT  - The Journal of dermatology
JID - 7600545
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Biomarkers, Tumor/*blood
MH  - Carcinoma, Squamous Cell/*blood
MH  - Female
MH  - Gas Chromatography-Mass Spectrometry
MH  - Humans
MH  - Male
MH  - Melanoma/*blood
MH  - Metabolomics
MH  - Middle Aged
MH  - Principal Component Analysis
MH  - Skin Neoplasms/*blood
OTO - NOTNLM
OT  - biomarker
OT  - gas chromatography/triple quadrupole mass spectrometry
OT  - melanoma
OT  - serum metabolomics
OT  - squamous cell carcinoma
EDAT- 2017/06/09 06:00
MHDA- 2018/07/10 06:00
CRDT- 2017/06/09 06:00
PHST- 2017/04/10 00:00 [received]
PHST- 2017/04/21 00:00 [accepted]
PHST- 2017/06/09 06:00 [pubmed]
PHST- 2018/07/10 06:00 [medline]
PHST- 2017/06/09 06:00 [entrez]
AID - 10.1111/1346-8138.13921 [doi]
PST - ppublish
SO  - J Dermatol. 2017 Nov;44(11):1268-1275. doi: 10.1111/1346-8138.13921. Epub 2017
      Jun 8.