PMID- 28586085
OWN - NLM
STAT- MEDLINE
DCOM- 20171003
LR  - 20181202
IS  - 1365-2249 (Electronic)
IS  - 0009-9104 (Linking)
VI  - 190
IP  - 1
DP  - 2017 Oct
TI  - Enrichment of IL-17A(+) IFN-gamma(+) and IL-22(+) IFN-gamma(+) T cell subsets is 
      associated with reduction of NKp44(+) ILC3s in the terminal ileum of Crohn's
      disease patients.
PG  - 143-153
LID - 10.1111/cei.12996 [doi]
AB  - Crohn's disease (CD) is a chronic inflammatory condition of the human
      gastrointestinal tract whose aetiology remains largely unknown. Dysregulated
      adaptive immune responses and defective innate immunity both contribute to this
      process. In this study, we demonstrated that the interleukin (IL)-17A(+)
      interferon (IFN)-gamma(+) and IL-22(+) IFN-gamma(+) T cell subsets accumulated
      specifically in the inflamed terminal ileum of CD patients. These cells had
      higher expression of Ki-67 and were active cytokine producers. In addition, their
      proportions within both the IL-17A-producer and IL-22-producer populations were
      increased significantly. These data suggest that IL-17A(+) IFN-gamma(+) and
      IL-22(+) IFN-gamma(+) T cell subsets might represent the pathogenic T helper type
      17 (Th17) population in the context of intestinal inflammation for CD patients.
      In the innate immunity compartment we detected a dramatic alteration of both
      phenotype and function of the intestinal innate lymphoid cells (ILCs), that play 
      an important role in the maintenance of mucosal homeostasis. In the inflamed gut 
      the frequency of the NKp44(-) CD117(-) ILC1s subset was increased significantly, 
      while the frequency of NKp44(+) ILC3s was reduced. Furthermore, the frequency of 
      human leucocyte antigen D-related (HLA-DR)-expressing-NKp44(+) ILC3s was also
      reduced significantly. Interestingly, the decrease in the NKp44(+) ILC3s
      population was associated with an increase of pathogenic IL-17A(+) IFN-gamma(+)
      and IL-22(+) IFN-gamma(+) T cell subsets in the adaptive compartment. This might 
      suggest a potential link between NKp44(+) ILC3s and the IL-17A(+) IFN-gamma(+)
      and IL-22(+) IFN-gamma(+) T cell subsets in the terminal ileum of CD patients.
CI  - (c) 2017 British Society for Immunology.
FAU - Li, J
AU  - Li J
AUID- ORCID: 0000-0003-2234-4325
AD  - Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine,
      University of Florida, Gainesville, FL, USA.
FAU - Doty, A L
AU  - Doty AL
AD  - Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine,
      University of Florida, Gainesville, FL, USA.
FAU - Tang, Y
AU  - Tang Y
AD  - Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine,
      University of Florida, Gainesville, FL, USA.
FAU - Berrie, D
AU  - Berrie D
AD  - Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine,
      University of Florida, Gainesville, FL, USA.
FAU - Iqbal, A
AU  - Iqbal A
AD  - Department of Surgery, College of Medicine, University of Florida, Gainesville,
      FL, USA.
FAU - Tan, S A
AU  - Tan SA
AD  - Department of Surgery, College of Medicine, University of Florida, Gainesville,
      FL, USA.
FAU - Clare-Salzler, M J
AU  - Clare-Salzler MJ
AD  - Department of Pathology, Immunology, and Laboratory Medicine, College of
      Medicine, University of Florida Health Science Center, Gainesville, FL, USA.
FAU - Wallet, S M
AU  - Wallet SM
AD  - Department of Oral Biology, College of Dentistry, University of Florida Health
      Science Center, Gainesville, FL, USA.
FAU - Glover, S C
AU  - Glover SC
AD  - Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine,
      University of Florida, Gainesville, FL, USA.
LA  - eng
PT  - Journal Article
DEP - 20170707
PL  - England
TA  - Clin Exp Immunol
JT  - Clinical and experimental immunology
JID - 0057202
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Interleukin-17)
RN  - 0 (Interleukins)
RN  - 0 (NCR2 protein, human)
RN  - 0 (Natural Cytotoxicity Triggering Receptor 2)
RN  - 82115-62-6 (Interferon-gamma)
RN  - XEO71E2E45 (interleukin-22)
SB  - IM
MH  - Adaptive Immunity
MH  - Adult
MH  - Aged
MH  - Cell Movement
MH  - Cells, Cultured
MH  - Crohn Disease/*immunology
MH  - Female
MH  - HLA-DR Antigens/metabolism
MH  - Humans
MH  - Ileum/*immunology
MH  - Immunity, Innate
MH  - Inflammation/*immunology
MH  - Interferon-gamma/metabolism
MH  - Interleukin-17/metabolism
MH  - Interleukins/metabolism
MH  - Lymphocyte Activation
MH  - Lymphocytes/*immunology
MH  - Male
MH  - Middle Aged
MH  - Natural Cytotoxicity Triggering Receptor 2/metabolism
MH  - T-Lymphocyte Subsets/*immunology
MH  - Th17 Cells/*immunology
PMC - PMC5588779
OTO - NOTNLM
OT  - *Crohn's disease
OT  - *T cells
OT  - *innate lymphoid cells
EDAT- 2017/06/07 06:00
MHDA- 2017/10/04 06:00
CRDT- 2017/06/07 06:00
PHST- 2017/05/30 00:00 [accepted]
PHST- 2017/06/07 06:00 [pubmed]
PHST- 2017/10/04 06:00 [medline]
PHST- 2017/06/07 06:00 [entrez]
AID - 10.1111/cei.12996 [doi]
PST - ppublish
SO  - Clin Exp Immunol. 2017 Oct;190(1):143-153. doi: 10.1111/cei.12996. Epub 2017 Jul 
      7.