PMID- 28570624
OWN - NLM
STAT- MEDLINE
DCOM- 20170928
LR  - 20170928
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 6
DP  - 2017
TI  - Macular Bruch's membrane defect and dome-shaped macula in high myopia.
PG  - e0178998
LID - 10.1371/journal.pone.0178998 [doi]
AB  - PURPOSE: To examine an association between macular Bruch's membrane defects
      (MBMD) and a dome-shaped appearance of the macula (DSM). DESIGN: Retrospective,
      observational case series study. METHODS: The study included highly myopic
      individuals who were consecutively examined between May 2014 and December 2015.
      The patients underwent swept-source optical coherence tomography (OCT) for
      visualization of DSM and MBMDs defined as Bruch s membrane defects located at a
      distance of maximal 1500 mum from the foveola. RESULTS: Out of 1983 highly myopic
      eyes (1057 patients), 166 eyes (8.4%; 95% confidence interval (CI):7.2%,9.6%))
      showed a DSM and 534 eyes showed a MBMD. In multivariate binary regression
      analysis, higher prevalence of DSM was associated with a higher prevalence of a
      MBMD (P<0.001; OR: 1.96; 95%CI: 1.40, 2.75) after adjusting for longer axial
      length (P<0.001; odds ratio (OR): 1.27; 95%CI: 1.16, 1.38). In eyes with a DSM
      partially surrounded by a MBMD, the retina, retinal pigment epithelium (RPE) and 
      choroid appeared relatively unchanged in the central region with Bruch s membrane
      (BM) preserved. In the ring-like BM-free region surrounding the central prominent
      island of the DSM, the RPE, the outer and middle retinal layers, the
      choriocapillaris and the middle-sized choroidal vessel layer were absent. In
      association with a DSM, three MBMD types were differentiated: MBMDs in patchy
      chorioretinal atrophy, MBMDs in choroidal neovascularization-related macular
      atrophy, and MBMDs as temporally extending large parapapillary gamma zone.
      CONCLUSIONS: Presence of a DSM was significantly associated with the presence of 
      MBMDs. The morphology of the DSM in association with MBMDs may be associated with
      a focal relaxation of the posterior sclera, no longer pushed outward by an
      expanding BM but allowed to partially bulge inward, leading to the formation of a
      DSM.
FAU - Fang, Yuxin
AU  - Fang Y
AUID- ORCID: http://orcid.org/0000-0003-0350-1786
AD  - Department of Ophthalmology and Visual Science, Tokyo Medical and Dental
      University, Tokyo, Japan.
FAU - Jonas, Jost B
AU  - Jonas JB
AD  - Department of Ophthalmology, Medical Faculty Mannheim of the
      Ruprecht-Karls-University of Heidelberg, Heidelberg, Germany.
FAU - Yokoi, Tae
AU  - Yokoi T
AD  - Department of Ophthalmology and Visual Science, Tokyo Medical and Dental
      University, Tokyo, Japan.
FAU - Cao, Kejia
AU  - Cao K
AD  - Department of Ophthalmology and Visual Science, Tokyo Medical and Dental
      University, Tokyo, Japan.
FAU - Shinohara, Kosei
AU  - Shinohara K
AD  - Department of Ophthalmology and Visual Science, Tokyo Medical and Dental
      University, Tokyo, Japan.
FAU - Ohno-Matsui, Kyoko
AU  - Ohno-Matsui K
AD  - Department of Ophthalmology and Visual Science, Tokyo Medical and Dental
      University, Tokyo, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170601
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bruch Membrane/metabolism/*pathology
MH  - Child
MH  - Female
MH  - Humans
MH  - Macula Lutea/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Myopia/metabolism/*pathology
MH  - Young Adult
PMC - PMC5453614
EDAT- 2017/06/02 06:00
MHDA- 2017/09/29 06:00
CRDT- 2017/06/02 06:00
PHST- 2017/02/16 00:00 [received]
PHST- 2017/05/22 00:00 [accepted]
PHST- 2017/06/02 06:00 [entrez]
PHST- 2017/06/02 06:00 [pubmed]
PHST- 2017/09/29 06:00 [medline]
AID - 10.1371/journal.pone.0178998 [doi]
AID - PONE-D-17-06452 [pii]
PST - epublish
SO  - PLoS One. 2017 Jun 1;12(6):e0178998. doi: 10.1371/journal.pone.0178998.
      eCollection 2017.