PMID- 28568890
OWN - NLM
STAT- MEDLINE
DCOM- 20190204
LR  - 20190215
IS  - 1522-726X (Electronic)
IS  - 1522-1946 (Linking)
VI  - 91
IP  - 2
DP  - 2018 Feb 1
TI  - Myocardial Mass Contributes to the Discrepancy Between Anatomic Stenosis Severity
      Assessed by Intravascular Ultrasound and Fractional Flow Reserve in Intermediate 
      Lesions of the Coronary Artery.
PG  - 182-191
LID - 10.1002/ccd.27072 [doi]
AB  - OBJECTIVES: The present study investigated the major contributors to the
      discrepancy between the minimal lumen area (MLA) and fractional flow reserve
      (FFR). BACKGROUND: There was considerable discrepancy between MLA or diameter
      stenosis (DS) and FFR. METHODS: We enrolled 744 patients with intermediate
      stenoses of the left anterior descending artery (LAD). Summed epicardial coronary
      artery length distal to the target stenosis was obtained from each longest view
      of the vessels on the coronary angiograms. Mismatching was defined as a lesion
      with FFR of >0.80 and MLA smaller than the best cut-off value (BCV) for
      predicting FFR of </=0.80. Reverse mismatching was defined as a lesion with FFR
      of </=0.80 and MLA larger than the BCV. RESULTS: Summed epicardial coronary
      artery length was longer at the lesions of proximal LAD than that of middle LAD
      (380 mm +/- 82 mm vs. 341 mm +/- 80 mm, P < 0.001). Reverse mismatching was found
      more frequently in the proximal than middle LAD (28.3% vs. 5.5%, P < 0.001).
      Independent predictors of FFR </= 0.80 were age, male, multi-vessel disease,
      proximal LAD lesion, MLA, DS, plaque burden at distal reference, lesion length
      and summed epicardial coronary artery length. Proximal LAD lesion was an
      independent predictor of reverse mismatching (hazard ratio 3.162, 1.858-5.382, P 
      < 0.001). CONCLUSIONS: Myocardial mass subtended by a lesion is an important
      factor predicting FFR </=0.80 and discrepancy between FFR and MLA. Myocardial
      mass subtended by a lesion should be considered when determining the
      revascularization therapy by intravascular ultrasound parameters. (c) 2017 Wiley 
      Periodicals, Inc.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Yoon, Myeong-Ho
AU  - Yoon MH
AUID- ORCID: 0000-0002-6412-8594
AD  - Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
FAU - Tahk, Seung-Jea
AU  - Tahk SJ
AD  - Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
FAU - Lim, Hong-Seok
AU  - Lim HS
AD  - Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
FAU - Yang, Hyoung-Mo
AU  - Yang HM
AD  - Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
FAU - Seo, Kyoung-Woo
AU  - Seo KW
AD  - Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
FAU - Choi, Byoung-Joo
AU  - Choi BJ
AD  - Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
FAU - Choi, So-Yeon
AU  - Choi SY
AD  - Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
FAU - Hwang, Gyo-Seung
AU  - Hwang GS
AD  - Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
FAU - Park, Jin-Sun
AU  - Park JS
AD  - Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
FAU - Shin, Joon-Han
AU  - Shin JH
AD  - Department of Cardiology, Ajou University School of Medicine, Suwon, Korea.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20170601
PL  - United States
TA  - Catheter Cardiovasc Interv
JT  - Catheterization and cardiovascular interventions : official journal of the
      Society for Cardiac Angiography & Interventions
JID - 100884139
SB  - IM
MH  - Aged
MH  - *Cardiac Catheterization
MH  - *Coronary Angiography
MH  - Coronary Artery Disease/*diagnostic imaging/pathology/physiopathology
MH  - Coronary Stenosis/*diagnostic imaging/pathology/physiopathology
MH  - Coronary Vessels/*diagnostic imaging/physiopathology
MH  - Female
MH  - *Fractional Flow Reserve, Myocardial
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Myocardium/*pathology
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Reproducibility of Results
MH  - *Ultrasonography, Interventional
OTO - NOTNLM
OT  - *FFR
OT  - *mismatching
OT  - *myocardial mass
EDAT- 2017/06/02 06:00
MHDA- 2019/02/05 06:00
CRDT- 2017/06/02 06:00
PHST- 2016/09/20 00:00 [received]
PHST- 2017/03/29 00:00 [accepted]
PHST- 2017/06/02 06:00 [pubmed]
PHST- 2019/02/05 06:00 [medline]
PHST- 2017/06/02 06:00 [entrez]
AID - 10.1002/ccd.27072 [doi]
PST - ppublish
SO  - Catheter Cardiovasc Interv. 2018 Feb 1;91(2):182-191. doi: 10.1002/ccd.27072.
      Epub 2017 Jun 1.