PMID- 28558065
OWN - NLM
STAT- MEDLINE
DCOM- 20170921
LR  - 20170921
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 5
DP  - 2017
TI  - Prediabetes is associated with the modulation of antigen-specific Th1/Tc1 and
      Th17/Tc17 responses in latent Mycobacterium tuberculosis infection.
PG  - e0178000
LID - 10.1371/journal.pone.0178000 [doi]
AB  - Type 2 diabetes mellitus (DM) is associated with the down modulation of Th1, Th2 
      and Th17 responses in latent Mycobacterium tuberculosis infection but the role of
      prediabetes (PDM) in this setting is not well understood. To examine the role of 
      CD4+ and CD8+ T cell cytokines in latent tuberculosis (LTB) with coincident PDM, 
      we studied the baseline, mycobacterial, control antigen and mitogen-stimulated T 
      cell cytokine responses in LTB individuals with (LTB-PDM; n = 20) or without
      (LTB-NDM; n = 20) concomitant prediabetes. LTB-PDM is characterized by diminished
      frequencies of mono-and dual-functional CD4+ Th1 and Th17 cells and
      mono-functional Th2 cells at baseline and/or following mycobacterial-antigen
      stimulation in comparison to LTB-NDM. LTB-PDM is also characterized by diminished
      frequencies of mono-functional CD8+ Tc1, Tc2 and Tc17 cells at baseline and/or
      following mycobacterial-antigen stimulation in comparison to LTB-NDM. LTB-PDM is 
      therefore characterized by diminished frequencies of antigen-specific Th1/Tc1 and
      Th17/Tc17 cells, indicating that PDM is associated with alterations of the immune
      response in latent TB associated with compromised CD4+ and CD8+ T cell function.
FAU - Kumar, Nathella Pavan
AU  - Kumar NP
AD  - National Institutes of Health-NIRT-International Center for Excellence in
      Research, Chennai, India.
FAU - Moideen, Kadar
AU  - Moideen K
AD  - National Institutes of Health-NIRT-International Center for Excellence in
      Research, Chennai, India.
FAU - Dolla, Chandrakumar
AU  - Dolla C
AD  - National Institute for Research in Tuberculosis, Chennai, India.
FAU - Kumaran, Paul
AU  - Kumaran P
AD  - National Institute for Research in Tuberculosis, Chennai, India.
FAU - Babu, Subash
AU  - Babu S
AUID- ORCID: http://orcid.org/0000-0001-9783-8042
AD  - National Institutes of Health-NIRT-International Center for Excellence in
      Research, Chennai, India.
LA  - eng
PT  - Journal Article
DEP - 20170530
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Cytokines)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antigens, Bacterial/immunology
MH  - CD4-Positive T-Lymphocytes/immunology
MH  - CD8-Positive T-Lymphocytes/immunology
MH  - Case-Control Studies
MH  - Cytokines/*immunology
MH  - Female
MH  - Humans
MH  - Latent Tuberculosis/complications/*immunology
MH  - Male
MH  - Middle Aged
MH  - Mycobacterium tuberculosis/immunology
MH  - Prediabetic State/complications/*immunology
MH  - Th1 Cells/*immunology
MH  - Th17 Cells/*immunology
MH  - Th2 Cells/*immunology
PMC - PMC5448753
EDAT- 2017/05/31 06:00
MHDA- 2017/09/22 06:00
CRDT- 2017/05/31 06:00
PHST- 2017/04/03 00:00 [received]
PHST- 2017/05/05 00:00 [accepted]
PHST- 2017/05/31 06:00 [entrez]
PHST- 2017/05/31 06:00 [pubmed]
PHST- 2017/09/22 06:00 [medline]
AID - 10.1371/journal.pone.0178000 [doi]
AID - PONE-D-17-12932 [pii]
PST - epublish
SO  - PLoS One. 2017 May 30;12(5):e0178000. doi: 10.1371/journal.pone.0178000.
      eCollection 2017.