PMID- 28554860
OWN - NLM
STAT- MEDLINE
DCOM- 20180427
LR  - 20180427
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 653
DP  - 2017 Jul 13
TI  - Chronic sleep fragmentation exacerbates amyloid beta deposition in Alzheimer's
      disease model mice.
PG  - 362-369
LID - S0304-3940(17)30452-4 [pii]
LID - 10.1016/j.neulet.2017.05.054 [doi]
AB  - Sleep fragmentation due to intermittent nocturnal arousal resulting in a
      reduction of total sleep time and sleep efficiency is a common symptom among
      people with Alzheimer's disease (AD) and elderly people with normal cognitive
      function. Although epidemiological studies have indicated an association between 
      sleep fragmentation and elevated risk of AD, a relevant disease model to
      elucidate the underlying mechanisms was lacking owing to technical limitations.
      Here we successfully induced chronic sleep fragmentation in AD model mice using a
      recently developed running-wheel-based device and demonstrate that chronic sleep 
      fragmentation increases amyloid beta deposition. Notably, the severity of amyloid
      beta deposition exhibited a significant positive correlation with the extent of
      sleep fragmentation. These findings provide a useful contribution to the
      development of novel treatments that decelerate the disease course of AD in the
      patients, or decrease the risk of developing AD in healthy elderly people through
      the improvement of sleep quality.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Minakawa, Eiko N
AU  - Minakawa EN
AD  - Department of Degenerative Neurological Diseases, National Institute of
      Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi,
      Kodaira, Tokyo, 187-8502, Japan. Electronic address: minakawa@ncnp.go.jp.
FAU - Miyazaki, Koyomi
AU  - Miyazaki K
AD  - Physiologically Active Substances Research Group, Biomedical Research Institute, 
      National Institute of Advanced Industrial Science and Technology, Central 6,
      1-1-1 Higashi, Tsukuba, Ibaraki, 305-8566, Japan. Electronic address:
      k-miyazaki@aist.go.jp.
FAU - Maruo, Kazushi
AU  - Maruo K
AD  - Department of Clinical Epidemiology, Translational Medical Center, National
      Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo,
      187-8551, Japan. Electronic address: maruo@ncnp.go.jp.
FAU - Yagihara, Hiroko
AU  - Yagihara H
AD  - Department of Degenerative Neurological Diseases, National Institute of
      Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi,
      Kodaira, Tokyo, 187-8502, Japan. Electronic address: bonkobara@ncnp.go.jp.
FAU - Fujita, Hiromi
AU  - Fujita H
AD  - Department of Degenerative Neurological Diseases, National Institute of
      Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi,
      Kodaira, Tokyo, 187-8502, Japan. Electronic address: hfujita@ncnp.go.jp.
FAU - Wada, Keiji
AU  - Wada K
AD  - Department of Degenerative Neurological Diseases, National Institute of
      Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi,
      Kodaira, Tokyo, 187-8502, Japan; Translational Medical Center, National Center of
      Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan.
      Electronic address: wada@ncnp.go.jp.
FAU - Nagai, Yoshitaka
AU  - Nagai Y
AD  - Department of Degenerative Neurological Diseases, National Institute of
      Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi,
      Kodaira, Tokyo, 187-8502, Japan; Department of Neurotherapeutics, Osaka
      University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka, 565-0871,
      Japan. Electronic address: nagai@neurother.med.osaka-u.ac.jp.
LA  - eng
PT  - Journal Article
DEP - 20170526
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Amyloid beta-Peptides)
SB  - IM
MH  - Alzheimer Disease/complications/*metabolism
MH  - Amyloid beta-Peptides/*metabolism
MH  - Animals
MH  - Disease Models, Animal
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Sleep Deprivation/*metabolism
MH  - Sleep Wake Disorders/etiology/*metabolism
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - Amyloid beta
OT  - Neurodegenerative diseases
OT  - Sleep disturbance
OT  - Sleep fragmentation
EDAT- 2017/05/31 06:00
MHDA- 2018/04/28 06:00
CRDT- 2017/05/31 06:00
PHST- 2017/01/27 00:00 [received]
PHST- 2017/04/20 00:00 [revised]
PHST- 2017/05/24 00:00 [accepted]
PHST- 2017/05/31 06:00 [pubmed]
PHST- 2018/04/28 06:00 [medline]
PHST- 2017/05/31 06:00 [entrez]
AID - S0304-3940(17)30452-4 [pii]
AID - 10.1016/j.neulet.2017.05.054 [doi]
PST - ppublish
SO  - Neurosci Lett. 2017 Jul 13;653:362-369. doi: 10.1016/j.neulet.2017.05.054. Epub
      2017 May 26.