PMID- 28524060
OWN - NLM
STAT- MEDLINE
DCOM- 20180412
LR  - 20180412
IS  - 1952-4013 (Electronic)
IS  - 1167-1122 (Linking)
VI  - 27
IP  - 3
DP  - 2017 Jun 1
TI  - High-frequency ultrasound imaging for cutaneous neurofibroma in patients with
      neurofibromatosis type I.
PG  - 260-265
LID - 10.1684/ejd.2017.3015 [doi]
AB  - Neurofibromas (NFs) are benign tumours arising from a nerve sheath, which are
      present in nearly all patients with neurofibromatosis type 1 (NF1).
      High-frequency ultrasound (HFU) systems, using frequencies over 20 MHz, were
      developed to improve visualization of skin tumours by means of increased
      resolution. To describe NFs by using HFU in patients with NF1. Anonymized HFU
      (25-MHz) images of NFs were randomized. Initially, two dermatologist
      investigators, with experience in HFU imaging of the skin, together described the
      ultrasound images and established eight criteria for NFs. The same task was then 
      repeated by two other dermatologists, also with experience in HFU imaging of the 
      skin, independently, to establish inter-observer agreement. A total of 108 NFs in
      29 patients were included. Superficial and subcutaneous NFs were hypoechoic with 
      a round to spindle shape. Plexiform NFs were ill-defined, consisting of multiple 
      hypoechoic linear zones. Good to excellent inter-observer agreement was found for
      six of the eight criteria (k>0.6). This is the first series describing HFU skin
      imaging of NFs in patients with NF1. Lateral extension that may correspond to
      involvement of an adjacent nerve seems to be specific to NFs.
FAU - Raffin, Delphine
AU  - Raffin D
AD  - Department of Dermatology, CHRU, Tours, France, University Francois-Rabelais,
      Tours, France.
FAU - Zaragoza, Julia
AU  - Zaragoza J
AD  - Department of Dermatology, CHRU, Tours, France, University Francois-Rabelais,
      Tours, France.
FAU - Georgescou, Gabriella
AU  - Georgescou G
AD  - Department of Dermatology, CHRU, Tours, France.
FAU - Mourtada, Youssef
AU  - Mourtada Y
AD  - Department of Dermatology, CHRU, Tours, France.
FAU - Maruani, Annabel
AU  - Maruani A
AD  - Department of Dermatology, CHRU, Tours, France, INSERM U930, University
      Francois-Rabelais, Tours, France.
FAU - Ossant, Frederic
AU  - Ossant F
AD  - INSERM U930, University Francois-Rabelais, Tours, France, CIC-IT, CHRU, Tours,
      France.
FAU - Patat, Frederic
AU  - Patat F
AD  - INSERM U930, University Francois-Rabelais, Tours, France, CIC-IT, CHRU, Tours,
      France.
FAU - Vaillant, Loic
AU  - Vaillant L
AD  - Department of Dermatology, CHRU, Tours, France, INSERM U930, University
      Francois-Rabelais, Tours, France.
FAU - Machet, Laurent
AU  - Machet L
AD  - Department of Dermatology, CHRU, Tours, France, INSERM U930, University
      Francois-Rabelais, Tours, France.
LA  - eng
PT  - Journal Article
PL  - France
TA  - Eur J Dermatol
JT  - European journal of dermatology : EJD
JID - 9206420
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neurofibromatosis 1/*diagnostic imaging/pathology
MH  - Prospective Studies
MH  - Skin Neoplasms/*diagnostic imaging/pathology
MH  - Ultrasonography/methods
MH  - Young Adult
OTO - NOTNLM
OT  - neurofibroma
OT  - neurofibromatosis type 1
OT  - skin
OT  - tumour
OT  - ultrasonography
EDAT- 2017/05/20 06:00
MHDA- 2018/04/13 06:00
CRDT- 2017/05/20 06:00
PHST- 2017/05/20 06:00 [pubmed]
PHST- 2018/04/13 06:00 [medline]
PHST- 2017/05/20 06:00 [entrez]
AID - ejd.2017.3015 [pii]
AID - 10.1684/ejd.2017.3015 [doi]
PST - ppublish
SO  - Eur J Dermatol. 2017 Jun 1;27(3):260-265. doi: 10.1684/ejd.2017.3015.