PMID- 28524056
OWN - NLM
STAT- MEDLINE
DCOM- 20180525
LR  - 20180525
IS  - 1952-4013 (Electronic)
IS  - 1167-1122 (Linking)
VI  - 27
IP  - 4
DP  - 2017 Aug 1
TI  - Dermatitis herpetiformis and bone mineral density: analysis of a French cohort of
      53 patients.
PG  - 353-358
LID - 10.1684/ejd.2017.3029 [doi]
AB  - The characteristics of patients with dermatitis herpetiformis (DH) in France is
      poorly documented. Furthermore, the risk of fractures and bone mineral density
      (BMD) in DH remain under-described, and recommendations for systematic screening 
      for osteoporosis in DH are lacking. To describe the characteristics of DH in a
      large French cohort and evaluate the association between BMD and features of
      osteoporosis. Patients were recruited from the French Association of Gluten
      Intolerants (AFDIAG) and a single university dermatology department. A telephone 
      questionnaire was used to record features of DH, history of fractures, calcium
      intake, treatment, and the gluten-free diet (GFD). Serum calcium and 25(OH)
      vitamin D3+D2 levels, as well as BMD, were measured. We included 53 patients (27 
      men) with a median age of 49 years (range: 23-86). Median disease duration before
      inclusion was 14 years (range: 2-55); 51 patients (96%) were adherent to a GFD
      and had no digestive symptoms. Overall, 18 (34%) had a history of fractures; 16
      high-velocity (traumatic) and two low-velocity (non-traumatic). Mean BMD,
      measured in 48 patients, was normal (femoral neck: 0.956 +/- 0.210 g/cm(2);
      lumbar spine: 1.091 +/- 1.199 g/cm(2)). In all, 18 patients (38%) had osteopenia 
      and one (2%) osteoporosis. T-score for bone density did not differ with and
      without fractures. Calcium intake and serum calcium level were normal in all
      patients. Screening for osteoporosis does not appear to be mandatory for DH
      patients with good adherence to a GFD and without digestive symptoms or
      additional risk factors of osteoporosis.
FAU - Lheure, Coralie
AU  - Lheure C
AD  - Assistance Publique-Hopitaux de Paris (APHP), Department of Dermatology, Henri
      Mondor Hospital, Creteil, France.
FAU - Ingen-Housz-Oro, Saskia
AU  - Ingen-Housz-Oro S
AD  - Assistance Publique-Hopitaux de Paris (APHP), Department of Dermatology, Henri
      Mondor Hospital, Creteil, France, EA 7379 EpiDermE (Epidemiologie en Dermatologie
      et Evaluation des Therapeutiques), UPEC, Creteil, France.
FAU - Guignard, Sandra
AU  - Guignard S
AD  - Assistance Publique-Hopitaux de Paris (APHP), Department of Rumathology, Hopital 
      Henri Mondor, Creteil, France.
FAU - Inaoui, Rachida
AU  - Inaoui R
AD  - Assistance Publique-Hopitaux de Paris (APHP), Department of Rumathology, Hopital 
      La Pitie Salpetriere, Paris, France.
FAU - Jolivet, Brigitte
AU  - Jolivet B
AD  - Association Francaise des Intolerants au Gluten, Paris, France.
FAU - Chevalier, Xavier
AU  - Chevalier X
AD  - Assistance Publique-Hopitaux de Paris (APHP), Department of Rumathology, Hopital 
      Henri Mondor, Creteil, France.
FAU - Wolkenstein, Pierre
AU  - Wolkenstein P
AD  - Assistance Publique-Hopitaux de Paris (APHP), Department of Dermatology, Henri
      Mondor Hospital, Creteil, France, Universite Paris-Est Creteil Val de Marne
      (UPEC), Creteil, France.
FAU - Fautrel, Bruno
AU  - Fautrel B
AD  - Assistance Publique-Hopitaux de Paris (APHP), Department of Rumathology, Hopital 
      La Pitie Salpetriere, Paris, France, GRC-UPMC 08 (EEMOIS), Institut Pierre-Louis 
      d'Epidemiologie et de Sante Publique, Sorbonne Universite, UMPC Universite Paris,
      France.
FAU - Chosidow, Oliver
AU  - Chosidow O
AD  - Assistance Publique-Hopitaux de Paris (APHP), Department of Dermatology, Henri
      Mondor Hospital, Creteil, France, EA 7379 EpiDermE (Epidemiologie en Dermatologie
      et Evaluation des Therapeutiques), UPEC, Creteil, France, Universite Paris-Est
      Creteil Val de Marne (UPEC), Creteil, France, Centre d'Investigation Clinique
      1430, AP-HP, Creteil, France.
LA  - eng
PT  - Journal Article
PL  - France
TA  - Eur J Dermatol
JT  - European journal of dermatology : EJD
JID - 9206420
RN  - 0 (Calcium, Dietary)
RN  - 0 (Folic Acid Antagonists)
RN  - 27YLU75U4W (Phosphorus)
RN  - 8W5C518302 (Dapsone)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Bone Density
MH  - Bone Diseases, Metabolic/*etiology/physiopathology
MH  - Calcium/blood
MH  - Calcium, Dietary
MH  - Dapsone/therapeutic use
MH  - Dermatitis Herpetiformis/*complications/*physiopathology/therapy
MH  - Diet, Gluten-Free
MH  - Female
MH  - Folic Acid Antagonists/therapeutic use
MH  - Fractures, Bone/etiology
MH  - France
MH  - Gastrointestinal Diseases/*etiology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteoporosis/etiology/physiopathology
MH  - Phosphorus/blood
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - France
OT  - bone mineral density
OT  - dermatitis herpetiformis
OT  - fracture
OT  - gluten intolerant
OT  - gluten-free
EDAT- 2017/05/20 06:00
MHDA- 2018/05/26 06:00
CRDT- 2017/05/20 06:00
PHST- 2017/05/20 06:00 [pubmed]
PHST- 2018/05/26 06:00 [medline]
PHST- 2017/05/20 06:00 [entrez]
AID - ejd.2017.3029 [pii]
AID - 10.1684/ejd.2017.3029 [doi]
PST - ppublish
SO  - Eur J Dermatol. 2017 Aug 1;27(4):353-358. doi: 10.1684/ejd.2017.3029.