PMID- 28510272
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20190829
IS  - 1932-8737 (Electronic)
IS  - 0160-9289 (Linking)
VI  - 40
IP  - 9
DP  - 2017 Sep
TI  - Diabetes mellitus is associated with increased acute kidney injury and 1-year
      mortality after transcatheter aortic valve replacement: A meta-analysis.
PG  - 726-731
LID - 10.1002/clc.22723 [doi]
AB  - BACKGROUND: Diabetes mellitus (DM) is associated with adverse outcomes after
      surgical aortic valve replacement. However, there are conflicting data on the
      impact of DM on outcomes of transcatheter aortic valve replacement (TAVR).
      HYPOTHESIS: DM is associated with poor outcomes after different cardiac
      procedures. Therefore, DM can also be associated with poor outcomes after TAVR.
      METHODS: We searched PubMed and Cochrane Central Register of Controlled Trials
      for studies that evaluated outcomes after TAVR and stratified at least 1 of the
      studied endpoints by DM status. The primary endpoint was all-cause mortality at 1
      year. Secondary endpoints were early (up to 30 days) mortality, acute kidney
      injury (AKI), cerebrovascular accident (CVA), major bleeding, and major vascular 
      complications. Pooled odds ratio (OR) and 95% confidence interval (CI) were
      calculated using random effects models. RESULTS: We included 64 studies with a
      total of 38 686 patients. DM was associated with significantly higher 1-year
      mortality (OR: 1.14, 95% CI: 1.04-1.26, P = 0.008) and periprocedural AKI (OR:
      1.28, 95% CI: 1.08-1.52, P = 0.004). On the other hand, there were no significant
      differences between diabetics and nondiabetics in early mortality, CVAs, major
      bleeding, or major vascular complications. CONCLUSIONS: DM is associated with
      increased 1-year mortality and periprocedural AKI in patients undergoing TAVR.
      The results of this study suggest that DM is a predictor of adverse outcomes in
      patients undergoing TAVR.
CI  - (c) 2017 Wiley Periodicals, Inc.
FAU - Mina, George S
AU  - Mina GS
AUID- ORCID: http://orcid.org/0000-0002-1638-7620
AD  - Department of Cardiology, Louisiana State University Health Sciences
      Center-Shreveport, Shreveport, Louisiana.
FAU - Gill, Priyanka
AU  - Gill P
AD  - Department of Cardiology, Louisiana State University Health Sciences
      Center-Shreveport, Shreveport, Louisiana.
FAU - Soliman, Demiana
AU  - Soliman D
AD  - Department of Cardiology, Louisiana State University Health Sciences
      Center-Shreveport, Shreveport, Louisiana.
FAU - Reddy, Pratap
AU  - Reddy P
AD  - Department of Cardiology, Louisiana State University Health Sciences
      Center-Shreveport, Shreveport, Louisiana.
FAU - Dominic, Paari
AU  - Dominic P
AD  - Department of Cardiology, Louisiana State University Health Sciences
      Center-Shreveport, Shreveport, Louisiana.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20170516
PL  - United States
TA  - Clin Cardiol
JT  - Clinical cardiology
JID - 7903272
SB  - IM
MH  - Acute Kidney Injury/diagnosis/*mortality
MH  - Aortic Valve Stenosis/diagnosis/mortality/*surgery
MH  - Cerebrovascular Disorders/diagnosis/mortality
MH  - Diabetes Mellitus/diagnosis/*mortality
MH  - Hemorrhage/diagnosis/mortality
MH  - Humans
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - Risk Assessment
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Transcatheter Aortic Valve Replacement/adverse effects/*mortality
MH  - Treatment Outcome
PMC - PMC6490528
OTO - NOTNLM
OT  - Diabetes Mellitus
OT  - Meta-analysis
OT  - Transcatheter Aortic Valve Replacement
EDAT- 2017/05/17 06:00
MHDA- 2018/06/05 06:00
CRDT- 2017/05/17 06:00
PHST- 2017/02/06 00:00 [received]
PHST- 2017/03/30 00:00 [revised]
PHST- 2017/04/05 00:00 [accepted]
PHST- 2017/05/17 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
PHST- 2017/05/17 06:00 [entrez]
AID - 10.1002/clc.22723 [doi]
PST - ppublish
SO  - Clin Cardiol. 2017 Sep;40(9):726-731. doi: 10.1002/clc.22723. Epub 2017 May 16.