PMID- 28505035
OWN - NLM
STAT- MEDLINE
DCOM- 20170901
LR  - 20170901
IS  - 1531-7021 (Electronic)
IS  - 1040-8738 (Linking)
VI  - 28
IP  - 5
DP  - 2017 Sep
TI  - Invasive fungal sinusitis: treatment of the orbit.
PG  - 522-533
LID - 10.1097/ICU.0000000000000394 [doi]
AB  - PURPOSE OF REVIEW: To summarize diagnostic techniques for invasive fungal
      rhinosinusitis and provide a review of treatment options once disease has spread 
      to the orbit. RECENT FINDINGS: Improved imaging criteria, polymerase chain
      reaction and other serologic tests show promise in advancing our ability to
      accurately diagnose invasive fungal disease. Currently, there exists three
      treatment options for infected orbital tissue: exenteration, conservative
      debridement and transcutaneous retrobulbar injection of amphotericin B.
      Exenteration, the most frequently reported intervention, has not been proven to
      enhance survival. Conservative debridement and transcutaneous retrobulbar
      injection of amphotericin B are increasingly considered reasonable first-line
      options. SUMMARY: Although investigative tools are improving, invasive fungal
      rhinosinusitis can still pose a diagnostic challenge. No one treatment option for
      the orbit has been proven superior to another. Therefore, it is justified to
      initiate therapy by prioritizing less morbid procedures. If deterioration is
      continually noted, more invasive interventions can then be employed. The
      treatment algorithm established at our institution is provided.
FAU - Kalin-Hajdu, Evan
AU  - Kalin-Hajdu E
AD  - Department of Ophthalmology; University of California, San Francisco, California,
      USA.
FAU - Hirabayashi, Kristin E
AU  - Hirabayashi KE
FAU - Vagefi, M Reza
AU  - Vagefi MR
FAU - Kersten, Robert C
AU  - Kersten RC
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Ophthalmol
JT  - Current opinion in ophthalmology
JID - 9011108
RN  - 0 (Antifungal Agents)
SB  - IM
MH  - Antifungal Agents/*therapeutic use
MH  - Debridement/*methods
MH  - Eye Infections, Fungal/*therapy
MH  - Humans
MH  - Mycoses/*therapy
MH  - Orbital Diseases/*therapy
EDAT- 2017/05/16 06:00
MHDA- 2017/09/02 06:00
CRDT- 2017/05/16 06:00
PHST- 2017/05/16 06:00 [pubmed]
PHST- 2017/09/02 06:00 [medline]
PHST- 2017/05/16 06:00 [entrez]
AID - 10.1097/ICU.0000000000000394 [doi]
PST - ppublish
SO  - Curr Opin Ophthalmol. 2017 Sep;28(5):522-533. doi: 10.1097/ICU.0000000000000394.