PMID- 28486560
OWN - NLM
STAT- MEDLINE
DCOM- 20170926
LR  - 20170926
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 5
DP  - 2017
TI  - Analysis of aqueous humor concentrations of cytokines in retinoblastoma.
PG  - e0177337
LID - 10.1371/journal.pone.0177337 [doi]
AB  - To investigate the components of the aqueous humor (AH) in patients with
      retinoblastoma (RB). We collected 0.1 ml AH of 35 children with RB and 20
      patients with congenital cataracts as controls. Multiplex enzyme-linked
      immunosorbent assays (ELISAs) and Luminex xMAP technology were used to assess 45 
      cytokines/chemokines, matrix metalloproteinases (MMPs), and acute-phase proteins 
      in the identification cohort. The concentrations of IL-6, IL-7, IL-8, IFN-gamma, 
      PIGF-1, VEGF-A, beta-NGF, HGF, EGF and FGF-2 were significantly higher in the AH 
      of patients with RB than those in the control group (P<0.05). The study showed
      that the higher levels of IP-10, IL-6, IL-7, IL-8, IFN-gamma, PIGF-1, VEGF-A,
      beta-NGF, HGF, EGF and FGF-2 in AH may be associated with RB. Our findings may
      facilitate a better understanding of the molecular pathways of tumors and solid
      molecular targets for new strategies for therapy and the earlier diagnosis of RB.
FAU - Cheng, Yong
AU  - Cheng Y
AD  - Department of Ophthalmology, People's Hospital, Peking University, Beijing,
      China.
AD  - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing,
      China.
AD  - Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, 
      Beijing, China.
FAU - Zheng, Shufeng
AU  - Zheng S
AD  - Eye Hospital, Tradition Chinese Medicine Hospital of Yulin, Shaanxi, China.
FAU - Pan, Chung-Ting
AU  - Pan CT
AD  - Department of Ophthalmology, Peking University International Hospital, Beijing,
      China.
FAU - Yuan, Mengke
AU  - Yuan M
AD  - Department of Ophthalmology, Beijing Shunyi Airport Hospital, Beijing, China.
FAU - Chang, Libin
AU  - Chang L
AD  - Department of Ophthalmology, Beijing Jingmei Group General Hospital, Beijing,
      China.
FAU - Yao, Yuou
AU  - Yao Y
AD  - Department of Ophthalmology, People's Hospital, Peking University, Beijing,
      China.
AD  - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing,
      China.
AD  - Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, 
      Beijing, China.
FAU - Zhao, Mingwei
AU  - Zhao M
AD  - Department of Ophthalmology, People's Hospital, Peking University, Beijing,
      China.
AD  - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing,
      China.
AD  - Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, 
      Beijing, China.
FAU - Liang, Jianhong
AU  - Liang J
AUID- ORCID: http://orcid.org/0000-0001-8695-2026
AD  - Department of Ophthalmology, People's Hospital, Peking University, Beijing,
      China.
AD  - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing,
      China.
AD  - Beijing Key Laboratory of Diagnosis and Therapy of Retinal and Choroid Diseases, 
      Beijing, China.
LA  - eng
PT  - Journal Article
DEP - 20170509
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Cytokines)
SB  - IM
MH  - Aqueous Humor/*metabolism
MH  - Case-Control Studies
MH  - Child, Preschool
MH  - Cytokines/*metabolism
MH  - Female
MH  - Humans
MH  - Infant
MH  - Male
MH  - Prospective Studies
MH  - Retinoblastoma/*metabolism
PMC - PMC5423669
EDAT- 2017/05/10 06:00
MHDA- 2017/09/28 06:00
CRDT- 2017/05/10 06:00
PHST- 2017/01/14 00:00 [received]
PHST- 2017/04/26 00:00 [accepted]
PHST- 2017/05/10 06:00 [entrez]
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2017/09/28 06:00 [medline]
AID - 10.1371/journal.pone.0177337 [doi]
AID - PONE-D-16-51587 [pii]
PST - epublish
SO  - PLoS One. 2017 May 9;12(5):e0177337. doi: 10.1371/journal.pone.0177337.
      eCollection 2017.