PMID- 28480554
OWN - NLM
STAT- MEDLINE
DCOM- 20180321
LR  - 20180321
IS  - 1526-4610 (Electronic)
IS  - 0017-8748 (Linking)
VI  - 57
IP  - 6
DP  - 2017 Jun
TI  - Vomiting and migraine-related clinical parameters in pediatric migraine.
PG  - 899-907
LID - 10.1111/head.13109 [doi]
AB  - OBJECTIVE/BACKGROUND: To investigate the characteristics of vomiting in pediatric
      migraineurs and the relationship of vomiting with other migraine-related
      parameters. METHODS: The cohort included children and adolescents with migraine
      attending a headache clinic of a tertiary pediatric medical center from 2010 to
      2016. Patients were identified by a retrospective database search. Data were
      collected from medical files. The presence of vomiting was associated with
      background and headache-related parameters. RESULTS: The study group included 453
      patients, 210 boys (46.4%) and 243 girls (53.6%), of mean age 11.3 +/- 3.7 years.
      Vomiting was reported by 161 patients (35.5%). On comparison of patients with and
      without vomiting, vomiting was found to be significantly associated with male
      gender (54% vs 42.1%, P < .018), younger age at migraine onset (8.0 +/- 3. years 
      vs 9.6 +/- 3.7 years, P < .001), younger age at clinic admission (10.5 +/- 3.
      years vs 11.6 +/- 3.6 years, P = .002), higher rate of awakening headache (64.1% 
      vs 38.7%, P < .001), lower headache frequency (10.5 +/- 10.3 headaches/month vs
      15.0 +/- 11.7 headaches/month, P < .001), higher rate of episodic vs chronic
      migraine (67% vs 58.7%, P < .001), and higher rates of paternal migraine (24.1%
      vs 10.1%, P < .001), migraine in both parents (9.3% vs 3.1%, P = .007), and
      migraine in either parent (57.5% vs 45.5%, P = .02). CONCLUSIONS: The higher rate
      of vomiting in the younger patients and the patients with awakening pain may be
      explained by a common underlying pathogenetic mechanism of vomiting and migraine 
      involving autonomic nerve dysfunction/immaturity. The association of vomiting
      with parental migraine points to a genetic component of vomiting and migraine. It
      should be noted that some of the findings may simply reflect referral patterns in
      the tertiary clinic.
CI  - (c) 2017 American Headache Society.
FAU - Eidlitz-Markus, Tal
AU  - Eidlitz-Markus T
AD  - Pediatric Headache Clinic, Day Hospitalization Department, Schneider Children's
      Medical Center of Israel, Petach Tikva; and Sackler Faculty of Medicine, Tel Aviv
      University, Tel Aviv, Israel.
FAU - Haimi-Cohen, Yishai
AU  - Haimi-Cohen Y
AD  - Pediatric Headache Clinic, Day Hospitalization Department, Schneider Children's
      Medical Center of Israel, Petach Tikva; and Sackler Faculty of Medicine, Tel Aviv
      University, Tel Aviv, Israel.
FAU - Zeharia, Avraham
AU  - Zeharia A
AD  - Pediatric Headache Clinic, Day Hospitalization Department, Schneider Children's
      Medical Center of Israel, Petach Tikva; and Sackler Faculty of Medicine, Tel Aviv
      University, Tel Aviv, Israel.
LA  - eng
PT  - Journal Article
DEP - 20170507
PL  - United States
TA  - Headache
JT  - Headache
JID - 2985091R
SB  - IM
CIN - Headache. 2017 Jun;57(6):979-980. PMID: 28594121
MH  - Adolescent
MH  - Age of Onset
MH  - Analysis of Variance
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Migraine Disorders/*complications/epidemiology/physiopathology
MH  - Retrospective Studies
MH  - Sex Factors
MH  - Vomiting/*complications/epidemiology/physiopathology
OTO - NOTNLM
OT  - awakening pain
OT  - headache frequency
OT  - male
OT  - pediatric migraine
OT  - vomiting
OT  - young age
EDAT- 2017/05/10 06:00
MHDA- 2018/03/22 06:00
CRDT- 2017/05/09 06:00
PHST- 2016/11/03 00:00 [received]
PHST- 2017/02/04 00:00 [revised]
PHST- 2017/02/04 00:00 [accepted]
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2018/03/22 06:00 [medline]
PHST- 2017/05/09 06:00 [entrez]
AID - 10.1111/head.13109 [doi]
PST - ppublish
SO  - Headache. 2017 Jun;57(6):899-907. doi: 10.1111/head.13109. Epub 2017 May 7.