PMID- 28477683
OWN - NLM
STAT- MEDLINE
DCOM- 20180223
LR  - 20180223
IS  - 1878-5883 (Electronic)
IS  - 0022-510X (Linking)
VI  - 377
DP  - 2017 Jun 15
TI  - Evaluation of total, ceruloplasmin-associated and type II ferroxidase activities 
      in serum and cerebrospinal fluid of multiple sclerosis patients.
PG  - 133-136
LID - S0022-510X(17)30254-X [pii]
LID - 10.1016/j.jns.2017.04.021 [doi]
AB  - Multiple sclerosis (MS) patients have increased brain iron deposition with higher
      oxidative stress (OxS). These two features can be caused by an inefficient
      removal of free iron from extracellular compartment. Ferroxidase activity (Feox) 
      exerted by ceruloplasmin (FeoxCp) and by other molecules (FeoxII) appears to have
      a central role in this process. The aim of this study was to investigate serum
      and cerebrospinal fluid (CSF) total Feox, FeoxII and FeoxCp activities in MS
      patients and neurological controls. Serum and CSF Feox activity, FeoxII and
      FeoxCp activity was measured in 91 relapsing-remitting (RR) MS patients, 79
      subjects with other inflammatory neurological disorders (OIND) and 65 with
      non-inflammatory neurological disorders (NIND), as controls. This study was
      approved by the Local Committee for Medical Ethics in Research. Serum total Feox 
      activity was lower in MS group than in both NIND and OIND, with only the former
      control group differing significantly (p<0.001); FeoxII and FeoxCp activities
      were comparable among the groups. Serum Feox activities were not associated with 
      disease activity as assessed by clinical examination or by Magnetic Resonance
      Imaging (MRI). Only total Feox activity was detectable in the CSF and was not
      different in MS compared to either OIND or NIND. In conclusion, a condition of
      low systemic Feox may increase the susceptibility of MS patients to iron(II)
      mediated-oxidative damage. This alteration is not reflected in CSF, suggesting
      that agents endowed with Feox activity might have different impact in iron
      homeostasis in the central nervous system compared to periphery.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Trentini, Alessandro
AU  - Trentini A
AD  - Department of Biomedical and Specialist Surgical Sciences, University of Ferrara,
      44121 Ferrara, Italy.
FAU - Castellazzi, Massimiliano
AU  - Castellazzi M
AD  - Department of Biomedical and Specialist Surgical Sciences, University of Ferrara,
      44121 Ferrara, Italy.
FAU - Romani, Arianna
AU  - Romani A
AD  - Department of Biomedical and Specialist Surgical Sciences, University of Ferrara,
      44121 Ferrara, Italy.
FAU - Squerzanti, Monica
AU  - Squerzanti M
AD  - Department of Biomedical and Specialist Surgical Sciences, University of Ferrara,
      44121 Ferrara, Italy.
FAU - Baldi, Eleonora
AU  - Baldi E
AD  - Neurology Unit, Department of Neurosciences and Rehabilitation, Azienda
      Ospedaliera-Universitaria, Arcispedale S. Anna, 44124 Ferrara, Italy.
FAU - Caniatti, Maria Luisa
AU  - Caniatti ML
AD  - Neurology Unit, Department of Neurosciences and Rehabilitation, Azienda
      Ospedaliera-Universitaria, Arcispedale S. Anna, 44124 Ferrara, Italy.
FAU - Pugliatti, Maura
AU  - Pugliatti M
AD  - Department of Biomedical and Specialist Surgical Sciences, University of Ferrara,
      44121 Ferrara, Italy.
FAU - Granieri, Enrico
AU  - Granieri E
AD  - Department of Biomedical and Specialist Surgical Sciences, University of Ferrara,
      44121 Ferrara, Italy.
FAU - Fainardi, Enrico
AU  - Fainardi E
AD  - Unit of Neuroradiology, Careggi University Hospital, Firenze, Italy.
FAU - Bellini, Tiziana
AU  - Bellini T
AD  - Department of Biomedical and Specialist Surgical Sciences, University of Ferrara,
      44121 Ferrara, Italy. Electronic address: blt@unife.it.
FAU - Cervellati, Carlo
AU  - Cervellati C
AD  - Department of Biomedical and Specialist Surgical Sciences, University of Ferrara,
      44121 Ferrara, Italy.
LA  - eng
PT  - Journal Article
DEP - 20170413
PL  - Netherlands
TA  - J Neurol Sci
JT  - Journal of the neurological sciences
JID - 0375403
RN  - EC 1.- (Oxidoreductases)
RN  - EC 1.16.- (ferroxidase II)
RN  - EC 1.16.3.1 (Ceruloplasmin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Ceruloplasmin/*metabolism
MH  - Disability Evaluation
MH  - Female
MH  - Humans
MH  - Image Processing, Computer-Assisted
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Multiple Sclerosis/*blood/*cerebrospinal fluid/diagnostic imaging
MH  - Nervous System Diseases/blood/cerebrospinal fluid
MH  - Oxidoreductases/*blood/*cerebrospinal fluid
MH  - Statistics, Nonparametric
OTO - NOTNLM
OT  - Cerebrospinal fluid
OT  - Ceruloplasmin
OT  - Ferroxidase activity
OT  - Multiple sclerosis
OT  - Oxidative stress
OT  - Serum
EDAT- 2017/05/10 06:00
MHDA- 2018/02/24 06:00
CRDT- 2017/05/08 06:00
PHST- 2017/01/27 00:00 [received]
PHST- 2017/03/21 00:00 [revised]
PHST- 2017/04/11 00:00 [accepted]
PHST- 2017/05/08 06:00 [entrez]
PHST- 2017/05/10 06:00 [pubmed]
PHST- 2018/02/24 06:00 [medline]
AID - S0022-510X(17)30254-X [pii]
AID - 10.1016/j.jns.2017.04.021 [doi]
PST - ppublish
SO  - J Neurol Sci. 2017 Jun 15;377:133-136. doi: 10.1016/j.jns.2017.04.021. Epub 2017 
      Apr 13.