PMID- 28456631
OWN - NLM
STAT- MEDLINE
DCOM- 20170831
LR  - 20180406
IS  - 1528-0012 (Electronic)
IS  - 0016-5085 (Linking)
VI  - 153
IP  - 2
DP  - 2017 Aug
TI  - Global Prevalence of Helicobacter pylori Infection: Systematic Review and
      Meta-Analysis.
PG  - 420-429
LID - S0016-5085(17)35531-2 [pii]
LID - 10.1053/j.gastro.2017.04.022 [doi]
AB  - BACKGROUND & AIMS: The epidemiology of Helicobacter pylori infection has changed 
      with improvements in sanitation and methods of eradication. We performed a
      systematic review and meta-analysis to evaluate changes in the global prevalence 
      of H pylori infection. METHODS: We performed a systematic search of the MEDLINE
      and EMBASE databases for studies of the prevalence of H pylori infection
      published from January 1, 1970 through January 1, 2016. We analyzed data based on
      United Nations geoscheme regions and individual countries. We used a random
      effects model to calculate pooled prevalence estimates with 95% confidence
      intervals (CIs), weighted by study size. We extrapolated 2015 prevalence
      estimates to obtain the estimated number of individuals with H pylori infection. 
      RESULTS: Among 14,006 reports screened, we identified 263 full-text articles on
      the prevalence of H pylori infection; 184 were included in the final analysis,
      comprising data from 62 countries. Africa had the highest pooled prevalence of H 
      pylori infection (70.1%; 95% CI, 62.6-77.7), whereas Oceania had the lowest
      prevalence (24.4%; 95% CI, 18.5-30.4). Among individual countries, the prevalence
      of H pylori infection varied from as low as 18.9% in Switzerland (95% CI,
      13.1-24.7) to 87.7% in Nigeria (95% CI, 83.1-92.2). Based on regional prevalence 
      estimates, there were approximately 4.4 billion individuals with H pylori
      infection worldwide in 2015. CONCLUSIONS: In a systematic review and
      meta-analysis to assess the prevalence of H pylori infection worldwide, we
      observed large amounts of variation among regions-more than half the world's
      population is infected. These data can be used in development of customized
      strategies for the global eradication.
CI  - Copyright (c) 2017 AGA Institute. Published by Elsevier Inc. All rights reserved.
FAU - Hooi, James K Y
AU  - Hooi JKY
AD  - Department of Medicine and Therapeutics, Institute of Digestive Disease, State
      Key Laboratory of Digestive Diseases, LKS Institute of Health Science, Chinese
      University of Hong Kong, Hong Kong, China.
FAU - Lai, Wan Ying
AU  - Lai WY
AD  - Department of Medicine and Therapeutics, Institute of Digestive Disease, State
      Key Laboratory of Digestive Diseases, LKS Institute of Health Science, Chinese
      University of Hong Kong, Hong Kong, China.
FAU - Ng, Wee Khoon
AU  - Ng WK
AD  - Department of Medicine and Therapeutics, Institute of Digestive Disease, State
      Key Laboratory of Digestive Diseases, LKS Institute of Health Science, Chinese
      University of Hong Kong, Hong Kong, China; Department of Gastroenterology and
      Hepatology, Tan Tock Seng Hospital, Singapore.
FAU - Suen, Michael M Y
AU  - Suen MMY
AD  - Department of Medicine and Therapeutics, Institute of Digestive Disease, State
      Key Laboratory of Digestive Diseases, LKS Institute of Health Science, Chinese
      University of Hong Kong, Hong Kong, China.
FAU - Underwood, Fox E
AU  - Underwood FE
AD  - Departments of Medicine and Community Health Sciences, University of Calgary,
      Calgary, Alberta, Canada.
FAU - Tanyingoh, Divine
AU  - Tanyingoh D
AD  - Departments of Medicine and Community Health Sciences, University of Calgary,
      Calgary, Alberta, Canada.
FAU - Malfertheiner, Peter
AU  - Malfertheiner P
AD  - Department of Gastroenterology, Hepatology and Infectious Diseases,
      Otto-von-Guericke University of Magdeburg, Magdeburg, Germany.
FAU - Graham, David Y
AU  - Graham DY
AD  - Gastroenterology, Baylor College of Medicine, Houston, Texas.
FAU - Wong, Vincent W S
AU  - Wong VWS
AD  - Department of Medicine and Therapeutics, Institute of Digestive Disease, State
      Key Laboratory of Digestive Diseases, LKS Institute of Health Science, Chinese
      University of Hong Kong, Hong Kong, China.
FAU - Wu, Justin C Y
AU  - Wu JCY
AD  - Department of Medicine and Therapeutics, Institute of Digestive Disease, State
      Key Laboratory of Digestive Diseases, LKS Institute of Health Science, Chinese
      University of Hong Kong, Hong Kong, China.
FAU - Chan, Francis K L
AU  - Chan FKL
AD  - Department of Medicine and Therapeutics, Institute of Digestive Disease, State
      Key Laboratory of Digestive Diseases, LKS Institute of Health Science, Chinese
      University of Hong Kong, Hong Kong, China.
FAU - Sung, Joseph J Y
AU  - Sung JJY
AD  - Department of Medicine and Therapeutics, Institute of Digestive Disease, State
      Key Laboratory of Digestive Diseases, LKS Institute of Health Science, Chinese
      University of Hong Kong, Hong Kong, China.
FAU - Kaplan, Gilaad G
AU  - Kaplan GG
AD  - Departments of Medicine and Community Health Sciences, University of Calgary,
      Calgary, Alberta, Canada. Electronic address: ggkaplan@ucalgary.ca.
FAU - Ng, Siew C
AU  - Ng SC
AD  - Department of Medicine and Therapeutics, Institute of Digestive Disease, State
      Key Laboratory of Digestive Diseases, LKS Institute of Health Science, Chinese
      University of Hong Kong, Hong Kong, China. Electronic address:
      siewchienng@cuhk.edu.hk.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20170427
PL  - United States
TA  - Gastroenterology
JT  - Gastroenterology
JID - 0374630
SB  - AIM
SB  - IM
MH  - Africa/epidemiology
MH  - Americas/epidemiology
MH  - Asia/epidemiology
MH  - Europe/epidemiology
MH  - Global Health/*statistics & numerical data
MH  - Helicobacter Infections/*epidemiology/microbiology
MH  - *Helicobacter pylori
MH  - Humans
MH  - Oceania/epidemiology
MH  - Prevalence
OTO - NOTNLM
OT  - *Bacteria
OT  - *Europe
OT  - *Incidence
OT  - *Stomach
EDAT- 2017/05/01 06:00
MHDA- 2017/09/01 06:00
CRDT- 2017/05/01 06:00
PHST- 2017/02/06 00:00 [received]
PHST- 2017/04/07 00:00 [revised]
PHST- 2017/04/19 00:00 [accepted]
PHST- 2017/05/01 06:00 [pubmed]
PHST- 2017/09/01 06:00 [medline]
PHST- 2017/05/01 06:00 [entrez]
AID - S0016-5085(17)35531-2 [pii]
AID - 10.1053/j.gastro.2017.04.022 [doi]
PST - ppublish
SO  - Gastroenterology. 2017 Aug;153(2):420-429. doi: 10.1053/j.gastro.2017.04.022.
      Epub 2017 Apr 27.