PMID- 28455161
OWN - NLM
STAT- MEDLINE
DCOM- 20180905
LR  - 20180905
IS  - 1097-6779 (Electronic)
IS  - 0016-5107 (Linking)
VI  - 87
IP  - 2
DP  - 2018 Feb
TI  - Outcomes of screening gastroscopy in first-degree relatives of patients
      fulfilling hereditary diffuse gastric cancer criteria.
PG  - 397-404.e2
LID - S0016-5107(17)31818-7 [pii]
LID - 10.1016/j.gie.2017.04.016 [doi]
AB  - BACKGROUND AND AIMS: The aim of this study was to determine the yield of
      endoscopic screening in first-degree relatives (FDRs) of CDH1-negative hereditary
      diffuse-type gastric cancer (HDGC) patients. METHODS: In this retrospective
      observational cohort study, in 2 expert centers in the Netherlands data were
      collected on FDRs from families fulfilling the international HDGC criteria that
      underwent endoscopic screening. Extensive inspection of the stomach was performed
      by gastroscopy, taking random and/or targeted stomach biopsy specimens to
      identify diffuse-type gastric cancer. RESULTS: Between 2004 and 2016, 90 persons 
      (40% men; mean age, 48 years) from 40 families were offered endoscopic screening.
      The mean number of endoscopies per person was 3. The mean follow-up time was 46
      months and mean endoscopic interval 20 months. Signet ring cell carcinoma foci
      restricted to the mucosa (pT1a) were identified in 4 persons (4%) from 1 family, 
      which afterward was diagnosed with a germline CTNNA1 mutation. Advanced poorly
      cohesive gastric carcinoma was diagnosed in 1 person from another family.
      Intestinal metaplasia was diagnosed in 38 persons (42%) and low-grade dysplasia
      in 4 persons (4%). Additionally, in 40 persons (44%) scar tissue was observed in 
      the gastric mucosa, which can hinder the endoscopic detection of small white
      lesions typical for HDGC. CONCLUSIONS: Endoscopic screening in HDGC families
      without a pathogenic CDH1 mutation may be reasonable, as we detected signet ring 
      cell carcinomas in 6% of persons screened. However, the criteria and frequency of
      screening may have to be reconsidered.
CI  - Copyright (c) 2018 American Society for Gastrointestinal Endoscopy. Published by 
      Elsevier Inc. All rights reserved.
FAU - van der Post, Rachel S
AU  - van der Post RS
AD  - Department of Pathology, Radboud University Medical Center, Nijmegen, the
      Netherlands.
FAU - van Dieren, Jolanda
AU  - van Dieren J
AD  - Department of Gastroenterology, Netherlands Cancer Institute/Antoni van
      Leeuwenhoek, Amsterdam, the Netherlands.
FAU - Grelack, Anna
AU  - Grelack A
AD  - Department of Gastroenterology, Radboud University Medical Center, Nijmegen, the 
      Netherlands.
FAU - Hoogerbrugge, Nicoline
AU  - Hoogerbrugge N
AD  - Department of Human Genetics, Radboud University Medical Center, Nijmegen, the
      Netherlands.
FAU - van der Kolk, Lizet E
AU  - van der Kolk LE
AD  - Department of Clinical Genetics, Netherlands Cancer Institute/Antoni van
      Leeuwenhoek, Amsterdam, the Netherlands.
FAU - Snaebjornsson, Petur
AU  - Snaebjornsson P
AD  - Department of Pathology, Netherlands Cancer Institute/Antoni van Leeuwenhoek,
      Amsterdam, the Netherlands.
FAU - Lansdorp-Vogelaar, Iris
AU  - Lansdorp-Vogelaar I
AD  - Department of Public Health, Erasmus MC, University Medical Center, Rotterdam,
      the Netherlands.
FAU - van Krieken, J Han
AU  - van Krieken JH
AD  - Department of Pathology, Radboud University Medical Center, Nijmegen, the
      Netherlands.
FAU - Bisseling, Tanya M
AU  - Bisseling TM
AD  - Department of Gastroenterology, Radboud University Medical Center, Nijmegen, the 
      Netherlands.
FAU - Cats, Annemieke
AU  - Cats A
AD  - Department of Gastroenterology, Netherlands Cancer Institute/Antoni van
      Leeuwenhoek, Amsterdam, the Netherlands.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20170425
PL  - United States
TA  - Gastrointest Endosc
JT  - Gastrointestinal endoscopy
JID - 0010505
RN  - 0 (CDH1 protein, human)
RN  - 0 (CTNNA1 protein, human)
RN  - 0 (Cadherins)
RN  - 0 (alpha Catenin)
SB  - IM
CIN - Gastrointest Endosc. 2018 Feb;87(2):405-407. PMID: 29406927
MH  - Adult
MH  - Aged
MH  - Biopsy
MH  - Cadherins/genetics
MH  - Carcinoma, Signet Ring Cell/*diagnostic imaging/genetics/*pathology
MH  - Early Detection of Cancer/methods
MH  - Female
MH  - Gastric Mucosa/pathology
MH  - *Gastroscopy
MH  - Germ-Line Mutation
MH  - Humans
MH  - Male
MH  - Metaplasia/diagnostic imaging/*pathology
MH  - Middle Aged
MH  - Pedigree
MH  - Retrospective Studies
MH  - Stomach Neoplasms/*diagnostic imaging/genetics/*pathology
MH  - Young Adult
MH  - alpha Catenin/genetics
EDAT- 2017/04/30 06:00
MHDA- 2018/09/06 06:00
CRDT- 2017/04/30 06:00
PHST- 2017/02/13 00:00 [received]
PHST- 2017/04/14 00:00 [accepted]
PHST- 2017/04/30 06:00 [pubmed]
PHST- 2018/09/06 06:00 [medline]
PHST- 2017/04/30 06:00 [entrez]
AID - S0016-5107(17)31818-7 [pii]
AID - 10.1016/j.gie.2017.04.016 [doi]
PST - ppublish
SO  - Gastrointest Endosc. 2018 Feb;87(2):397-404.e2. doi: 10.1016/j.gie.2017.04.016.
      Epub 2017 Apr 25.