PMID- 28409746
OWN - NLM
STAT- MEDLINE
DCOM- 20180316
LR  - 20180713
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 58
IP  - 2
DP  - 2017
TI  - The Role of ADAM10 in Alzheimer's Disease.
PG  - 303-322
LID - 10.3233/JAD-170061 [doi]
AB  - As a member of the A Disintegrin And Metalloproteinase (ADAM) family, ADAM10 has 
      been identified as the constitutive alpha-secretase in the process of
      amyloid-beta protein precursor (AbetaPP) cleavage and plays a critical role in
      reducing the generation of the amyloid-beta (Abeta) peptides. Recent studies have
      demonstrated its beneficial role in alleviating the pathologic impairment in
      Alzheimer's disease (AD) both in vitro and in vivo. However, the role of ADAM10
      in AD and the underlying molecular mechanisms are still not well established.
      Increasing evidence indicates that ADAM10 not only reduces the generation of
      Abeta but may also affect the pathology of AD through potential mechanisms
      including reducing tau pathology, maintaining normal synaptic functions, and
      promoting hippocampal neurogenesis and the homeostasis of neuronal networks.
      Mechanistically, ADAM10 regulates these functions by interacting with
      postsynaptic substrates in brain, especially synaptic cell receptors and adhesion
      molecules. Furthermore, ADAM10 protein in platelets seems to be a promising
      biomarker for AD diagnosis. This review will summarize the role of ADAM10 in AD
      and highlight its functions besides its role as the alpha-secretase in AbetaPP
      cleavage. Meanwhile, we will discuss the therapeutic potential of ADAM10 in
      treating AD.
FAU - Yuan, Xiang-Zhen
AU  - Yuan XZ
AD  - Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao,
      China.
FAU - Sun, Sen
AU  - Sun S
AD  - Qingdao Blood Center, Qingdao, China.
FAU - Tan, Chen-Chen
AU  - Tan CC
AD  - Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao,
      China.
FAU - Yu, Jin-Tai
AU  - Yu JT
AD  - Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao,
      China.
FAU - Tan, Lan
AU  - Tan L
AD  - Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao,
      China.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
RN  - 0 (Amyloid beta-Protein Precursor)
RN  - 0 (tau Proteins)
RN  - EC 3.4.- (Amyloid Precursor Protein Secretases)
RN  - EC 3.4.24.81 (ADAM10 Protein)
SB  - IM
MH  - ADAM10 Protein/genetics/*metabolism/*therapeutic use
MH  - Alzheimer Disease/genetics/*metabolism/*therapy
MH  - Amyloid Precursor Protein Secretases/metabolism
MH  - Amyloid beta-Protein Precursor/metabolism
MH  - Humans
MH  - Models, Biological
MH  - tau Proteins/metabolism
OTO - NOTNLM
OT  - *ADAM10
OT  - *Alzheimer's disease
OT  - *amyloid protein
OT  - *amyloid-beta
OT  - *biomarker
OT  - *gliogenesis
OT  - *neurogenesis
OT  - *tau protein
EDAT- 2017/04/15 06:00
MHDA- 2018/03/17 06:00
CRDT- 2017/04/15 06:00
PHST- 2017/04/15 06:00 [pubmed]
PHST- 2018/03/17 06:00 [medline]
PHST- 2017/04/15 06:00 [entrez]
AID - JAD170061 [pii]
AID - 10.3233/JAD-170061 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2017;58(2):303-322. doi: 10.3233/JAD-170061.