PMID- 28399177
OWN - NLM
STAT- MEDLINE
DCOM- 20170905
LR  - 20190208
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 12
IP  - 4
DP  - 2017
TI  - Dermoscopic characteristics of melanoma according to the criteria "ulceration"
      and "mitotic rate" of the AJCC 2009 staging system for melanoma.
PG  - e0174871
LID - 10.1371/journal.pone.0174871 [doi]
AB  - OBJECTIVE: The present study was conducted to identify possible dermoscopic
      patterns, associated with mitotic rate > 1/mm2, histological ulceration in
      melanoma and metastatic disease. METHODS: For this retrospective data analysis
      all clinical and dermoscopic digital images of primary malignant melanomas
      between 2008 and 2013 documented at the Department of Dermatology Graz were
      included, using the internal image data-base. 550 patients with 559 melanomas
      were included. RESULTS: While clinical or dermoscopic analysis considered
      ulceration to be present in 120 (21.5%) and 117 (20.9%) of all lesions,
      respectively, histopathology reported ulceration in only 96 cases (17.2%). The
      presence of milky-red areas, shiny-white streaks, a blue-white veil and blue-grey
      areas in dermoscopy is highly correlated with histological ulceration and a
      mitotic rate > 1/mm2. The dermoscopic patterns shiny-white streaks, milky-red
      areas and blue-white veil were also significantly associated with development of 
      distant metastases. CONCLUSION: Our study proves a significant correlation
      between the dermoscopic patterns "blue white veil", "milky-red areas"and
      "shiny-white streaks"and the histological findings "ulceration"and "mitotic rate 
      > 1/mm2". Furthermore these dermoscopic patterns are highly related to distant
      metastases. Thus, dermoscopy renders earlier prognostic statements possible.
FAU - Deinlein, Teresa
AU  - Deinlein T
AD  - Department of Dermatology, Medical University of Graz, Graz, Austria.
FAU - Arzberger, Edith
AU  - Arzberger E
AD  - Department of Dermatology, Medical University of Graz, Graz, Austria.
FAU - Zalaudek, Iris
AU  - Zalaudek I
AD  - Department of Dermatology, Medical University of Graz, Graz, Austria.
FAU - Massone, Cesare
AU  - Massone C
AD  - Department of Dermatology, Medical University of Graz, Graz, Austria.
AD  - Department of Dermatology, Galliera Hospital, Genoa, Italy.
FAU - Garcias-Ladaria, Juan
AU  - Garcias-Ladaria J
AD  - Hospital General Universitari de Valencia, Valencia, Spain.
FAU - Oliveira, Andre
AU  - Oliveira A
AD  - Department of Dermatology, Hospital de Curry Cabral-Centro Hospitalar de Lisboa
      Central, Lisboa, Portugal.
FAU - Schulter, Gunter
AU  - Schulter G
AD  - Department of Psychology, Biological Psychology Unit, Karl-Franzens-University
      Graz, Graz, Austria.
FAU - Hofmann-Wellenhof, Rainer
AU  - Hofmann-Wellenhof R
AD  - Department of Dermatology, Medical University of Graz, Graz, Austria.
LA  - eng
PT  - Journal Article
DEP - 20170411
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - *Dermoscopy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Melanoma/*pathology
MH  - Middle Aged
MH  - Mitosis
MH  - Neoplasm Metastasis/pathology
MH  - Neoplasm Staging
MH  - Retrospective Studies
MH  - Skin/*pathology
MH  - Skin Neoplasms/*pathology
MH  - Ulcer/*pathology
PMC - PMC5388460
EDAT- 2017/04/12 06:00
MHDA- 2017/09/07 06:00
CRDT- 2017/04/12 06:00
PHST- 2016/09/17 00:00 [received]
PHST- 2017/03/16 00:00 [accepted]
PHST- 2017/04/12 06:00 [entrez]
PHST- 2017/04/12 06:00 [pubmed]
PHST- 2017/09/07 06:00 [medline]
AID - 10.1371/journal.pone.0174871 [doi]
AID - PONE-D-16-37380 [pii]
PST - epublish
SO  - PLoS One. 2017 Apr 11;12(4):e0174871. doi: 10.1371/journal.pone.0174871.
      eCollection 2017.