PMID- 28397981
OWN - NLM
STAT- MEDLINE
DCOM- 20171018
LR  - 20180121
IS  - 1879-3479 (Electronic)
IS  - 0020-7292 (Linking)
VI  - 138
IP  - 1
DP  - 2017 Jul
TI  - A randomized trial of local endometrial injury during ovulation induction cycles.
PG  - 47-52
LID - 10.1002/ijgo.12178 [doi]
AB  - OBJECTIVE: To investigate the effect of endometrial injury on pregnancy outcomes 
      among infertile women taking clomifene citrate. METHODS: A prospective randomized
      trial was undertaken at an Egyptian hospital between January 26, 2015, and July
      17, 2016. Eligible women (>/=1 year primary/secondary/unexplained infertility,
      aged 20-35 years, day-2 follicle-stimulating hormone <12 IU/L, normal
      prolactin/thyroid function/uterine cavity, >/=1 patent tube, male partner with
      normal semen count and motility, 3 cycles of clomifene citrate without success)
      were randomly allocated (1:1) using computer-generated numbers into intervention 
      (received endometrial injury on cycle day 15-24) or control groups (sham
      procedure). Women began ovulation induction on days 3-5 of the following cycle.
      Participants and investigators were not masked to group assignment. The primary
      outcomes were clinical pregnancy, spontaneous abortion, and multiple pregnancy
      rates. Women who completed follow-up were included in analyses. RESULTS: The
      intervention group included 52 women and the control group 53 women. The clinical
      pregnancy rate was significantly higher in the intervention group (37% [n=19])
      than in the control group (13% [n=7]; P=0.006). No differences between the
      intervention and control groups were noted for spontaneous abortion rate (11%
      [2/19] vs 29% [2/7]; P=0.287) or multiple pregnancy rate (11% [2/19] vs 14%
      [1/7]; P=0.790). No adverse effects were reported. CONCLUSION: Endometrial injury
      before ovulation induction could improve chances of pregnancy and its outcomes.
      CLINICALTRIALS.GOV: NCT02345837.
CI  - (c) 2017 International Federation of Gynecology and Obstetrics.
FAU - Helmy, Medhat E E
AU  - Helmy MEE
AD  - Obstetrics and Gynecology Department, Faculty of Medicine, Menoufia University,
      Shebin-Elkom, Egypt.
FAU - Maher, Mohammad A
AU  - Maher MA
AD  - Obstetrics and Gynecology Department, Faculty of Medicine, Menoufia University,
      Shebin-Elkom, Egypt.
FAU - Elkhouly, Nabih I
AU  - Elkhouly NI
AD  - Obstetrics and Gynecology Department, Faculty of Medicine, Menoufia University,
      Shebin-Elkom, Egypt.
FAU - Ramzy, Mahmoud
AU  - Ramzy M
AD  - Obstetrics and Gynecology Department, Faculty of Medicine, Menoufia University,
      Shebin-Elkom, Egypt.
LA  - eng
SI  - ClinicalTrials.gov/NCT02345837
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20170504
PL  - United States
TA  - Int J Gynaecol Obstet
JT  - International journal of gynaecology and obstetrics: the official organ of the
      International Federation of Gynaecology and Obstetrics
JID - 0210174
RN  - 0 (Fertility Agents, Female)
RN  - 1HRS458QU2 (Clomiphene)
SB  - IM
MH  - Adult
MH  - Clomiphene/*therapeutic use
MH  - Endometrium/*injuries/surgery
MH  - Female
MH  - Fertility Agents, Female/*therapeutic use
MH  - Humans
MH  - Infertility, Female/drug therapy/physiopathology/surgery/*therapy
MH  - Luteal Phase/physiology
MH  - Ovulation/physiology
MH  - Ovulation Induction/*methods
MH  - Pregnancy
MH  - *Pregnancy Outcome
MH  - Prospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - Endometrial injury
OT  - Infertility treatment
OT  - Ovulation induction
OT  - Pipelle biopsy sampling
OT  - Pregnancy outcomes
EDAT- 2017/04/12 06:00
MHDA- 2017/10/19 06:00
CRDT- 2017/04/12 06:00
PHST- 2016/11/23 00:00 [received]
PHST- 2017/02/08 00:00 [revised]
PHST- 2017/04/07 00:00 [accepted]
PHST- 2017/04/12 06:00 [pubmed]
PHST- 2017/10/19 06:00 [medline]
PHST- 2017/04/12 06:00 [entrez]
AID - 10.1002/ijgo.12178 [doi]
PST - ppublish
SO  - Int J Gynaecol Obstet. 2017 Jul;138(1):47-52. doi: 10.1002/ijgo.12178. Epub 2017 
      May 4.