PMID- 28387664
OWN - NLM
STAT- MEDLINE
DCOM- 20180226
LR  - 20180627
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 58
IP  - 1
DP  - 2017
TI  - Efficacy of Hearing Aids on the Cognitive Status of Patients with Alzheimer's
      Disease and Hearing Loss: A Multicenter Controlled Randomized Trial.
PG  - 123-137
LID - 10.3233/JAD-160793 [doi]
AB  - BACKGROUND/OBJECTIVE: This study evaluated the cognitive benefit of hearing aids 
      (HA) in older patients with Alzheimer's disease (AD) and hearing loss (HL) after 
      a 6- and 12-month period of utilization. METHODS: A multicenter double-blind
      randomized placebo-controlled trial was conducted in patients aged more than 65
      years. A group was equipped with active HA for 6 months (active group) and a
      second group had placebo HA for 6 months (placebo group) followed by a secondary 
      activation phase for a further 6 months (semi crossover procedure). Both groups
      were retested after a 12-month period. The primary endpoint was the change from
      baseline of the Alzheimer's Disease Assessment Scale-Cognitive subscale (ADAS
      Cog) after a 6-month period in both groups and after 6 months of secondary HA
      activation in the placebo group. A smaller cognitive decline should be obtained
      with HA use; an increase in ADAS Cog score of less than 6 points was defined a
      success. RESULTS: Fifty-one patients aged 68 to 99 years were included; 38
      attended the 6-month visit: 18 in the active group and 20 in the placebo group.
      At 6 months, 14 (82.4%) successes were noticed in the active group, and 15
      (88.2%) in the placebo group (p = 1.0); delta ADAS Cog in the active group was
      1.8+/-5.3 and 1.3+/-5.3 in the placebo group (p = 0.8). In the placebo group,
      after the secondary HA activation, no significant improvement was observed.
      CONCLUSION: No significant effect of HA use was observed after 6 months of
      follow-up in patients with AD and HL.
FAU - Nguyen, Marie-France
AU  - Nguyen MF
AD  - Geriatric Medicine Unit, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre
      Benite, France.
FAU - Bonnefoy, Marc
AU  - Bonnefoy M
AD  - Geriatric Medicine Unit, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre
      Benite, France.
AD  - University Claude Bernard Lyon 1, Faculty of Medicine Lyon Sud, Pierre Benite,
      France.
FAU - Adrait, Arnaud
AU  - Adrait A
AD  - Geriatric Medicine Unit, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre
      Benite, France.
FAU - Gueugnon, Marine
AU  - Gueugnon M
AD  - Clinical Research Unit, Pole IMER, Hospices Civils de Lyon, Lyon, France.
FAU - Petitot, Charles
AU  - Petitot C
AD  - Geriatric Medicine Unit, Lyon Sud Hospital, Hospices Civils de Lyon, Pierre
      Benite, France.
FAU - Collet, Lionel
AU  - Collet L
AD  - Department of Audiology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon,
      France.
FAU - Roux, Adeline
AU  - Roux A
AD  - Clinical Research Unit, Pole IMER, Hospices Civils de Lyon, Lyon, France.
FAU - Perrot, Xavier
AU  - Perrot X
AD  - University Claude Bernard Lyon 1, Faculty of Medicine Lyon Sud, Pierre Benite,
      France.
AD  - Department of Audiology, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon,
      France.
AD  - Institute of Sciences and Techniques for Rehabilitation (ISTR), Lyon 1
      University, University of Lyon, Lyon, France.
CN  - ADPHA study group
LA  - eng
SI  - ClinicalTrials.gov/NCT00488007
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Alzheimer Disease/*complications/rehabilitation
MH  - Audiometry
MH  - Cognition Disorders/*etiology/rehabilitation
MH  - Cross-Over Studies
MH  - Double-Blind Method
MH  - Female
MH  - *Hearing Aids
MH  - Hearing Loss/*complications/*rehabilitation
MH  - Humans
MH  - Male
MH  - Neuropsychological Tests
OTO - NOTNLM
OT  - *Alzheimer's disease
OT  - *hearing aids
OT  - *hearing loss
OT  - *non-pharmacological treatment
OT  - *randomized controlledclinical trial
EDAT- 2017/04/08 06:00
MHDA- 2018/02/27 06:00
CRDT- 2017/04/08 06:00
PHST- 2017/04/08 06:00 [pubmed]
PHST- 2018/02/27 06:00 [medline]
PHST- 2017/04/08 06:00 [entrez]
AID - JAD160793 [pii]
AID - 10.3233/JAD-160793 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2017;58(1):123-137. doi: 10.3233/JAD-160793.