PMID- 28385314
OWN - NLM
STAT- MEDLINE
DCOM- 20170710
LR  - 20170713
IS  - 1558-3597 (Electronic)
IS  - 0735-1097 (Linking)
VI  - 69
IP  - 14
DP  - 2017 Apr 11
TI  - Management of Ventricular Arrhythmias in Patients With Advanced Heart Failure.
PG  - 1842-1860
LID - S0735-1097(17)30510-7 [pii]
LID - 10.1016/j.jacc.2017.01.047 [doi]
AB  - Advanced heart failure (A-HF) is characterized by progressive symptoms of heart
      failure despite optimal therapy. In patients with A-HF, ventricular arrhythmias
      (VAs) are common. Clinical studies evaluating different therapies to prevent VAs 
      had very limited representation of patients with A-HF. Among antiarrhythmic
      drugs, only amiodarone reduces VAs, although its use may be associated with
      increased mortality. Catheter ablation with substrate modification is effective
      to achieve VA suppression in patients with A-HF, including those with left
      ventricular assist devices. In high-risk cases, temporary mechanical hemodynamic 
      support tailored to the individual patient on the basis of presentation and
      hemodynamic conditions may be beneficial. Advanced therapies for pump failure or 
      refractory VAs, including heart transplantation and durable mechanical
      circulatory support, may be required in high-risk patients who are reasonable
      candidates for these surgical therapies. In this review, the authors discuss
      important management considerations in patients with VAs and A-HF.
CI  - Copyright (c) 2017 American College of Cardiology Foundation. Published by
      Elsevier Inc. All rights reserved.
FAU - Santangeli, Pasquale
AU  - Santangeli P
AD  - Cardiovascular Division, Hospital of the University of Pennsylvania,
      Philadelphia, Pennsylvania.
FAU - Rame, J Eduardo
AU  - Rame JE
AD  - Cardiovascular Division, Hospital of the University of Pennsylvania,
      Philadelphia, Pennsylvania.
FAU - Birati, Edo Y
AU  - Birati EY
AD  - Cardiovascular Division, Hospital of the University of Pennsylvania,
      Philadelphia, Pennsylvania.
FAU - Marchlinski, Francis E
AU  - Marchlinski FE
AD  - Cardiovascular Division, Hospital of the University of Pennsylvania,
      Philadelphia, Pennsylvania. Electronic address:
      francis.marchlinski@uphs.upenn.edu.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
RN  - 0 (Anti-Arrhythmia Agents)
SB  - AIM
SB  - IM
MH  - Anti-Arrhythmia Agents/therapeutic use
MH  - Arrhythmias, Cardiac/etiology/*therapy
MH  - Catheter Ablation
MH  - Heart Failure/*complications
MH  - Heart Transplantation
MH  - Heart-Assist Devices
MH  - Humans
OTO - NOTNLM
OT  - antiarrhythmic drugs
OT  - cardiac transplantation
OT  - catheter ablation
OT  - hemodynamic support devices
OT  - outcomes
EDAT- 2017/04/08 06:00
MHDA- 2017/07/14 06:00
CRDT- 2017/04/08 06:00
PHST- 2016/12/15 00:00 [received]
PHST- 2017/01/19 00:00 [revised]
PHST- 2017/01/23 00:00 [accepted]
PHST- 2017/04/08 06:00 [entrez]
PHST- 2017/04/08 06:00 [pubmed]
PHST- 2017/07/14 06:00 [medline]
AID - S0735-1097(17)30510-7 [pii]
AID - 10.1016/j.jacc.2017.01.047 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 2017 Apr 11;69(14):1842-1860. doi: 10.1016/j.jacc.2017.01.047.