PMID- 28379858
OWN - NLM
STAT- MEDLINE
DCOM- 20170620
LR  - 20170620
IS  - 1531-7021 (Electronic)
IS  - 1040-8738 (Linking)
VI  - 28
IP  - 4
DP  - 2017 Jul
TI  - Keratolimbal allograft.
PG  - 377-381
LID - 10.1097/ICU.0000000000000374 [doi]
AB  - PURPOSE OF REVIEW: Keratolimbal allograft (KLAL) transplants limbal tissue
      attached to a corneoscleral carrier from a cadaveric donor to deliver a large
      number of stem cells to the recipient. The present article will provide a review 
      of KLAL focusing on the recent literature. RECENT FINDINGS: Recent findings
      pertain to tissue selection, immunosuppression and adverse event profiles, and
      postoperative complications (particularly related to immunologic rejection).
      SUMMARY: KLAL permits the treatment of limbal stem cell deficiency eyes when
      there is no available living-related or autograft tissue with minimal risk of
      irreversible toxicity from modern systemic immunosuppression. The prevention of
      immunologic graft rejection with the use of systemic immunosuppression after KLAL
      is critical and may require extending systemic immunosuppression treatment longer
      than previously thought. With vigilant postoperative management, KLAL can allow
      successful treatment of the most severely diseased eyes.
FAU - Cheung, Albert Y
AU  - Cheung AY
AD  - aCincinnati Eye Institute bUniversity of Cincinnati, Cincinnati, Ohio, USA.
FAU - Holland, Edward J
AU  - Holland EJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Ophthalmol
JT  - Current opinion in ophthalmology
JID - 9011108
SB  - IM
MH  - Corneal Diseases/*surgery
MH  - Epithelial Cells/*transplantation
MH  - Graft Rejection/etiology
MH  - Humans
MH  - Immunosuppression/methods
MH  - Limbus Corneae/*pathology
MH  - Postoperative Complications
MH  - Sclera/transplantation
MH  - Stem Cell Transplantation/*methods
MH  - Transplantation, Homologous
EDAT- 2017/04/06 06:00
MHDA- 2017/06/21 06:00
CRDT- 2017/04/06 06:00
PHST- 2017/04/06 06:00 [pubmed]
PHST- 2017/06/21 06:00 [medline]
PHST- 2017/04/06 06:00 [entrez]
AID - 10.1097/ICU.0000000000000374 [doi]
PST - ppublish
SO  - Curr Opin Ophthalmol. 2017 Jul;28(4):377-381. doi: 10.1097/ICU.0000000000000374.