PMID- 28341252
OWN - NLM
STAT- MEDLINE
DCOM- 20170419
LR  - 20170419
IS  - 1097-6787 (Electronic)
IS  - 0190-9622 (Linking)
VI  - 76
IP  - 2
DP  - 2017 Feb
TI  - Correlation between digital epiluminescence microscopy parameters and
      histopathological changes in lentigo maligna and solar lentigo: A dermoscopic
      index for the diagnosis of lentigo maligna.
PG  - 234-243
LID - S0190-9622(16)30688-0 [pii]
LID - 10.1016/j.jaad.2016.08.032 [doi]
AB  - BACKGROUND: The clinical and dermoscopic differentiation between lentigo maligna 
      (LM) and solar lentigo (SL)/initial seborrheic keratosis (SK) may be difficult.
      OBJECTIVE: Our aim was to identify digital epiluminescence microscopy
      (DELM)-specific criteria that can be helpful in distinguishing LM from SL/SK and 
      to propose a new model of LM dermoscopic progression based on a study of
      DELM-histopathological correlation. METHODS: A total of 167 consecutive doubtful 
      pigmented lesions of the head (105 LM and 62 SL/SK) were studied. DELM assessment
      was based on the presence or absence of 15 DELM parameters that were subsequently
      examined histologically. Statistical analysis was performed to determine which
      DELM parameters were most strongly associated with LM. RESULTS: The finding of at
      least 1 of 4 parameters (ie, brown globules, a "necklace" pigment network, an
      atypical pigment network, and dark-brown/blue-gray ribbonlike structures) showed 
      to be an extremely sensitive (99%) and specific (83.9%) DELM criterion to
      discriminate between LM and SL/SK. LIMITATIONS: Our findings were obtained by
      examining medium-high magnification DELM images. CONCLUSIONS: The finding of 1 or
      more among the 4 above-mentioned DELM parameters allows for the correct
      identification of 99.0% of the LM lesions, and - when the score is 0 - the
      correct classification as non-LM, of 83.9% of the SL/SK lesions.
CI  - Copyright (c) 2016 American Academy of Dermatology, Inc. Published by Elsevier
      Inc. All rights reserved.
FAU - Annessi, Giorgio
AU  - Annessi G
AD  - Melanoma Unit, Istituto Dermopatico dell'Immacolata, Istituto di Ricovero e Cura 
      a Carattere Scientifico, Fondazione Luigi Maria Monti (IRCCS-FLMM), Rome, Italy; 
      Laboratory of Dermatopathology, Istituto Dermopatico dell'Immacolata, Istituto di
      Ricovero e Cura a Carattere Scientifico, Fondazione Luigi Maria Monti
      (IRCCS-FLMM), Rome, Italy. Electronic address: g.annessi@idi.it.
FAU - Bono, Riccardo
AU  - Bono R
AD  - Melanoma Unit, Istituto Dermopatico dell'Immacolata, Istituto di Ricovero e Cura 
      a Carattere Scientifico, Fondazione Luigi Maria Monti (IRCCS-FLMM), Rome, Italy; 
      Department of Dermatology, Istituto Dermopatico dell'Immacolata, Istituto di
      Ricovero e Cura a Carattere Scientifico, Fondazione Luigi Maria Monti
      (IRCCS-FLMM), Rome, Italy.
FAU - Abeni, Damiano
AU  - Abeni D
AD  - Clinical Epidemiology Unit, Istituto Dermopatico dell'Immacolata, Istituto di
      Ricovero e Cura a Carattere Scientifico, Fondazione Luigi Maria Monti
      (IRCCS-FLMM), Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20161026
PL  - United States
TA  - J Am Acad Dermatol
JT  - Journal of the American Academy of Dermatology
JID - 7907132
SB  - IM
MH  - Aged
MH  - *Dermoscopy/methods
MH  - Diagnosis, Differential
MH  - Female
MH  - Head and Neck Neoplasms/*diagnostic imaging/pathology
MH  - Humans
MH  - Hutchinson's Melanotic Freckle/*diagnostic imaging/pathology
MH  - Keratosis, Seborrheic/*diagnostic imaging/pathology
MH  - Male
MH  - Skin Neoplasms/*diagnostic imaging/pathology
OTO - NOTNLM
OT  - dermoscopy
OT  - diagnostic index
OT  - digital epiluminescence microscopy
OT  - histology
OT  - lentigo maligna
OT  - sensitivity and specificity
OT  - solar lentigo/seborrheic keratosis
EDAT- 2017/03/28 06:00
MHDA- 2017/04/20 06:00
CRDT- 2017/03/26 06:00
PHST- 2016/02/03 00:00 [received]
PHST- 2016/08/16 00:00 [revised]
PHST- 2016/08/16 00:00 [accepted]
PHST- 2017/03/26 06:00 [entrez]
PHST- 2017/03/28 06:00 [pubmed]
PHST- 2017/04/20 06:00 [medline]
AID - S0190-9622(16)30688-0 [pii]
AID - 10.1016/j.jaad.2016.08.032 [doi]
PST - ppublish
SO  - J Am Acad Dermatol. 2017 Feb;76(2):234-243. doi: 10.1016/j.jaad.2016.08.032. Epub
      2016 Oct 26.