PMID- 28315037
OWN - NLM
STAT- MEDLINE
DCOM- 20170818
LR  - 20181113
IS  - 1573-2568 (Electronic)
IS  - 0163-2116 (Linking)
VI  - 62
IP  - 6
DP  - 2017 Jun
TI  - Incidence of and Risk Factors for Free Bowel Perforation in Patients with Crohn's
      Disease.
PG  - 1607-1614
LID - 10.1007/s10620-017-4539-5 [doi]
AB  - BACKGROUND: Incidence of and risk factors for intestinal free perforation (FP) in
      patients with Crohn's disease (CD) are not established. AIM: To establish rate of
      and risk factors for FP in a large cohort of CD patients. METHODS: Medical
      records of CD patients who visited Asan Medical Center from June 1989 to December
      2012 were reviewed. After matching the FP patients to controls (1:4) by gender,
      year, and age at CD diagnosis, and disease location, their clinical
      characteristics were compared using conditional logistic regression analysis.
      RESULTS: Among 2043 patients who were included in our study cohort, 44 patients
      (2.15%) developed FP over a median follow-up period of 79.8 months (interquartile
      range 37.3-124.6), with an incidence of 3.18 per 1000 person-years [95%
      confidence interval (CI) 2.37-4.28]. All 44 patients underwent emergency surgery,
      and eight patients underwent reoperation within 12 months (8/44, 18.2%).
      Multivariable-adjusted analysis revealed that anti-TNF therapy [odds ratio (OR), 
      3.73; 95% CI 1.19-11.69; p = 0.024] was associated with an increased risk of FP. 
      CONCLUSIONS: The incidence of FP in a large cohort of Korean CD patients was
      2.15%, which was similar to that in Western reports. Anti-TNF therapy could be
      risk factors for FP.
FAU - Kim, Jong Wook
AU  - Kim JW
AD  - Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang,
      Korea.
FAU - Lee, Ho-Su
AU  - Lee HS
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan
      Medical Center, Seoul, Korea.
AD  - Department of Health Screening and Promotion Center, University of Ulsan College 
      of Medicine, Asan Medical Center, Seoul, Korea.
FAU - Ye, Byong Duk
AU  - Ye BD
AUID- ORCID: 0000-0001-6647-6325
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan
      Medical Center, Seoul, Korea. bdye@amc.seoul.kr.
AD  - Inflammatory Bowel Disease Center, University of Ulsan College of Medicine, Asan 
      Medical Center, Seoul, Korea. bdye@amc.seoul.kr.
FAU - Yang, Suk-Kyun
AU  - Yang SK
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan
      Medical Center, Seoul, Korea.
AD  - Inflammatory Bowel Disease Center, University of Ulsan College of Medicine, Asan 
      Medical Center, Seoul, Korea.
FAU - Hwang, Sung Wook
AU  - Hwang SW
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan
      Medical Center, Seoul, Korea.
FAU - Park, Sang Hyoung
AU  - Park SH
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan
      Medical Center, Seoul, Korea.
AD  - Inflammatory Bowel Disease Center, University of Ulsan College of Medicine, Asan 
      Medical Center, Seoul, Korea.
FAU - Yang, Dong-Hoon
AU  - Yang DH
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan
      Medical Center, Seoul, Korea.
FAU - Kim, Kyung-Jo
AU  - Kim KJ
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan
      Medical Center, Seoul, Korea.
AD  - Inflammatory Bowel Disease Center, University of Ulsan College of Medicine, Asan 
      Medical Center, Seoul, Korea.
FAU - Byeon, Jeong-Sik
AU  - Byeon JS
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan
      Medical Center, Seoul, Korea.
FAU - Myung, Seung-Jae
AU  - Myung SJ
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan
      Medical Center, Seoul, Korea.
FAU - Yoon, Yong Sik
AU  - Yoon YS
AD  - Inflammatory Bowel Disease Center, University of Ulsan College of Medicine, Asan 
      Medical Center, Seoul, Korea.
AD  - Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, 
      Asan Medical Center, Seoul, Korea.
FAU - Yu, Chang Sik
AU  - Yu CS
AD  - Inflammatory Bowel Disease Center, University of Ulsan College of Medicine, Asan 
      Medical Center, Seoul, Korea.
AD  - Department of Colon and Rectal Surgery, University of Ulsan College of Medicine, 
      Asan Medical Center, Seoul, Korea.
FAU - Kim, Jin-Ho
AU  - Kim JH
AD  - Department of Gastroenterology, University of Ulsan College of Medicine, Asan
      Medical Center, Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20170317
PL  - United States
TA  - Dig Dis Sci
JT  - Digestive diseases and sciences
JID - 7902782
RN  - 0 (Gastrointestinal Agents)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - B72HH48FLU (Infliximab)
SB  - AIM
SB  - IM
MH  - Adult
MH  - Case-Control Studies
MH  - Colonic Diseases/*epidemiology/etiology/surgery
MH  - Crohn Disease/complications/diagnosis/*drug therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Gastrointestinal Agents/therapeutic use
MH  - Humans
MH  - Ileal Diseases/*epidemiology/etiology/surgery
MH  - Incidence
MH  - Infliximab/therapeutic use
MH  - Intestinal Perforation/*epidemiology/etiology/surgery
MH  - Jejunal Diseases/*epidemiology/etiology/surgery
MH  - Male
MH  - Reoperation
MH  - Republic of Korea/epidemiology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Tumor Necrosis Factor-alpha/*antagonists & inhibitors
MH  - Young Adult
OTO - NOTNLM
OT  - *Anti-TNF
OT  - *Crohn's disease
OT  - *Intestinal perforation
OT  - *Stricture
EDAT- 2017/03/21 06:00
MHDA- 2017/08/19 06:00
CRDT- 2017/03/19 06:00
PHST- 2016/06/29 00:00 [received]
PHST- 2017/03/10 00:00 [accepted]
PHST- 2017/03/21 06:00 [pubmed]
PHST- 2017/08/19 06:00 [medline]
PHST- 2017/03/19 06:00 [entrez]
AID - 10.1007/s10620-017-4539-5 [doi]
AID - 10.1007/s10620-017-4539-5 [pii]
PST - ppublish
SO  - Dig Dis Sci. 2017 Jun;62(6):1607-1614. doi: 10.1007/s10620-017-4539-5. Epub 2017 
      Mar 17.