PMID- 28276579
OWN - NLM
STAT- MEDLINE
DCOM- 20170809
LR  - 20170809
IS  - 1600-0412 (Electronic)
IS  - 0001-6349 (Linking)
VI  - 96
IP  - 7
DP  - 2017 Jul
TI  - Glucose homeostasis, beta cell function, and insulin resistance in relation to
      vitamin D status after gestational diabetes mellitus.
PG  - 821-827
LID - 10.1111/aogs.13124 [doi]
AB  - INTRODUCTION: We wanted to determine vitamin D status after gestational diabetes 
      mellitus (GDM) and to evaluate whether levels of 25-hydroxyvitamin D3 (25OHD3 )
      are associated with beta cell function, insulin resistance or a diagnosis of
      diabetes after GDM. MATERIAL AND METHODS: Glucose homeostasis was assessed during
      a 75-g oral glucose tolerance test one to two years after delivery in 376 women
      with previous GDM (287 European and 78 non-European, including 33 Arab and 35
      Asian women). Insulin resistance was estimated using homeostasis model assessment
      of insulin resistance (HOMA-IR). The insulinogenic index (I/G30) and the
      disposition index [(I/G30)/HOMA-IR] were used to calculate insulin secretion.
      Concentrations of serum 25OHD3 were determined. RESULTS: Mean (+/-SD) 25OHD3
      concentration was 50.0 +/- 22.3 nmol/L and differed significantly among subgroups
      of body mass index, ethnicity, and glucose tolerance status; 53% had 25OHD3
      levels <50 nmol/L and 87% had 25OHD3 levels <75 nmol/L. There was a negative
      correlation between 25OHD3 concentration and HOMA-IR (p < 0.001) and a positive
      correlation between 25OHD3 and disposition index (p = 0.002) in univariable
      regression analysis. Correlations attenuated after adjustment for body mass
      index. In univariable regression analysis, 25OHD3 concentrations were
      significantly associated with diabetes after GDM (p = 0.004). However, in a
      multivariable model, non-European origin, HOMA-IR and insulinogenic index were
      significantly associated with postpartum diabetes, whereas 25OHD3 concentrations 
      were not. CONCLUSION: Vitamin D deficiency/insufficiency in previous GDM cases
      appears to be associated with beta cell dysfunction and insulin resistance, but
      not with postpartum diabetes when factors well known to influence type-2 diabetes
      were adjusted for.
CI  - (c) 2017 Nordic Federation of Societies of Obstetrics and Gynecology.
FAU - Shaat, Nael
AU  - Shaat N
AUID- ORCID: http://orcid.org/0000-0001-9163-8699
AD  - Department of Clinical Sciences, Lund University, Malmo, Sweden.
AD  - Department of Endocrinology, Skane University Hospital, Malmo, Sweden.
FAU - Ignell, Claes
AU  - Ignell C
AUID- ORCID: http://orcid.org/0000-0001-7317-1861
AD  - Department of Clinical Sciences, Lund University, Malmo, Sweden.
AD  - Department of Obstetrics and Gynecology, Office for Healthcare "Sund",
      Helsingborg, Sweden.
FAU - Katsarou, Anastasia
AU  - Katsarou A
AD  - Department of Clinical Sciences, Lund University, Malmo, Sweden.
AD  - Department of Endocrinology, Skane University Hospital, Malmo, Sweden.
FAU - Berntorp, Kerstin
AU  - Berntorp K
AD  - Department of Clinical Sciences, Lund University, Malmo, Sweden.
AD  - Department of Endocrinology, Skane University Hospital, Malmo, Sweden.
LA  - eng
PT  - Journal Article
DEP - 20170410
PL  - United States
TA  - Acta Obstet Gynecol Scand
JT  - Acta obstetricia et gynecologica Scandinavica
JID - 0370343
RN  - 0 (Blood Glucose)
RN  - P6YZ13C99Q (Calcifediol)
SB  - IM
MH  - Adult
MH  - Arabs
MH  - Asian Continental Ancestry Group
MH  - Blood Glucose/physiology
MH  - Calcifediol/*blood
MH  - Diabetes, Gestational/*blood/ethnology
MH  - Ethnic Groups
MH  - Female
MH  - Homeostasis
MH  - Humans
MH  - Insulin Resistance/physiology
MH  - Insulin-Secreting Cells/physiology
MH  - Postpartum Period/blood
MH  - Pregnancy
MH  - Sweden
MH  - Young Adult
OTO - NOTNLM
OT  - Disposition index
OT  - HOMA-IR
OT  - OGTT
OT  - ethnicity
OT  - gestational diabetes
OT  - insulinogenic index
OT  - postpartum diabetes
OT  - vitamin D
EDAT- 2017/03/10 06:00
MHDA- 2017/08/10 06:00
CRDT- 2017/03/10 06:00
PHST- 2016/11/18 00:00 [received]
PHST- 2017/03/01 00:00 [accepted]
PHST- 2017/03/10 06:00 [pubmed]
PHST- 2017/08/10 06:00 [medline]
PHST- 2017/03/10 06:00 [entrez]
AID - 10.1111/aogs.13124 [doi]
PST - ppublish
SO  - Acta Obstet Gynecol Scand. 2017 Jul;96(7):821-827. doi: 10.1111/aogs.13124. Epub 
      2017 Apr 10.