PMID- 28253208
OWN - NLM
STAT- MEDLINE
DCOM- 20180223
LR  - 20180327
IS  - 1473-5636 (Electronic)
IS  - 0960-8931 (Linking)
VI  - 27
IP  - 2
DP  - 2017 Apr
TI  - Neuropathic pain and quality of life after wide local excision and sentinel lymph
      node biopsy for melanoma: a multicentre study.
PG  - 121-125
LID - 10.1097/CMR.0000000000000321 [doi]
AB  - Wide local excision and sentinel lymph node biopsy is the mainstay of treatment
      for patients with melanoma. As survival outcomes improve, longer term quality of 
      life questions become more pertinent and this study aims to assess the factors
      which may play a role following surgery. A total of, 221 patients who underwent
      wide local excision and sentinel lymph node biopsy for melanoma (AJCC stage I and
      II) were recruited from three UK centres. These patients completed a patient
      outcome questionnaire, which included demographic and treatment data as well as
      quality of life and pain questionnaires. Pain was the only significant factor
      influencing the quality of life with a negative correlation seen between pain and
      quality of life scores (P<0.001). In total, 34% of patients reported pain at
      their surgical site and four (1.8%) patients scored as high risk for neuropathic 
      pain. Patients experiencing pain were significantly younger that those not
      reporting pain (median 55.0 vs. 63.5 years, P<0.001). Length of time since
      surgery did not correlate with pain nor quality of life scores. Our results
      suggest that following this common procedure a sizeable proportion of patients
      experience pain and poorer quality of life which does not improve with time. The 
      level of pain experienced is clinically significant and merits evaluation and
      treatment in this group of patients who are increasingly surviving their melanoma
      diagnosis. Further investigation into potential prophylactic measures is
      suggested.
FAU - Thomson, Collette H
AU  - Thomson CH
AD  - aDepartment of Plastic Surgery, Norfolk and Norwich University Hospital,
      NorwichbDepartment of Plastic Surgery, Oxford University Hospitals NHS Foundation
      Trust, OxfordcDepartment of Plastic Surgery, Leeds Teaching Hospitals NHS Trust, 
      LeedsdSchool of Medicine, Centre for Medical Education, Cardiff University,
      Cardiff, UK.
FAU - Cassell, Oliver
AU  - Cassell O
FAU - Peach, Howard
AU  - Peach H
FAU - Holloway, Samantha
AU  - Holloway S
FAU - Garioch, Jennifer
AU  - Garioch J
FAU - Moncrieff, Marc
AU  - Moncrieff M
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - England
TA  - Melanoma Res
JT  - Melanoma research
JID - 9109623
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Male
MH  - Melanoma/*surgery
MH  - Middle Aged
MH  - Neuralgia/*etiology
MH  - Pain Measurement
MH  - Patient Reported Outcome Measures
MH  - Postoperative Complications/*etiology
MH  - *Quality of Life
MH  - Sentinel Lymph Node Biopsy/adverse effects
MH  - Skin Neoplasms/*surgery
MH  - Time Factors
MH  - Young Adult
EDAT- 2017/03/03 06:00
MHDA- 2018/02/24 06:00
CRDT- 2017/03/03 06:00
PHST- 2017/03/03 06:00 [entrez]
PHST- 2017/03/03 06:00 [pubmed]
PHST- 2018/02/24 06:00 [medline]
AID - 10.1097/CMR.0000000000000321 [doi]
AID - 00008390-201704000-00008 [pii]
PST - ppublish
SO  - Melanoma Res. 2017 Apr;27(2):121-125. doi: 10.1097/CMR.0000000000000321.