PMID- 28251691
OWN - NLM
STAT- MEDLINE
DCOM- 20180326
LR  - 20181025
IS  - 1399-0012 (Electronic)
IS  - 0902-0063 (Linking)
VI  - 31
IP  - 5
DP  - 2017 May
TI  - Sinus tachycardia is associated with impaired exercise tolerance following heart 
      transplantation.
LID - 10.1111/ctr.12946 [doi]
AB  - BACKGROUND: Sinus tachycardia often presents in heart transplantation (HTx)
      recipients, but data on its effect on exercise performance are limited. METHODS: 
      Based on mean heart rate (HR) value 3 months after HTx, 181 patients transplanted
      from 2006 to 2015 at University of Nebraska Medical Center were divided into two 
      groups: (i) HR<95 beats/min (bpm, n=93); and (ii) HR>/=95 bpm (n=88).
      Cardiopulmonary exercise testing (CPET) was performed 1 year after HTx. RESULTS: 
      Mean HR at 3 months post-HTx was 94+/-11 bpm and did not change significantly at 
      1 year post-HTx (96+/-11 bpm, P=.13). HR>/=95 bpm at 3 months was associated with
      younger donor age (OR 1.1; CI 1.0-1.1, P=.02), female donors (OR -2.4; CI
      1.16-5.24 P=.02), and lack of donors' heavy alcohol use (OR -0.43; CI 0.17-0.61; 
      P=.04). HR>/=95 bpm at 3 months post-HTx was independently associated with
      decreased exercise capacity in metabolic equivalent (P=.008), reduced peak VO2
      (P=.006), and percent of predicted peak VO2 (P=.002) during CPET. CONCLUSIONS:
      HR>/=95 at 3 months following HTx is associated with reduced exercise tolerance
      in stable HTx recipients. Medical HR reduction after HTx could improve exercise
      performance after HTx and merits further investigation.
CI  - (c) 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Peled, Yael
AU  - Peled Y
AD  - Heart Center, Sheba Medical Center, Ramat Gan and Sackler School of Medicine, Tel
      Aviv University, Tel Aviv, Israel.
FAU - Varnado, Sara
AU  - Varnado S
AD  - Division of Cardiology, University of Nebraska Medical Center, Omaha, NE, USA.
FAU - Lowes, Brian D
AU  - Lowes BD
AD  - Division of Cardiology, University of Nebraska Medical Center, Omaha, NE, USA.
FAU - Zolty, Ronald
AU  - Zolty R
AD  - Division of Cardiology, University of Nebraska Medical Center, Omaha, NE, USA.
FAU - Lyden, Elizabeth R
AU  - Lyden ER
AD  - Department of Biostatistics, College of Public Health, University of Nebraska
      Medical Center, Omaha, NE, USA.
FAU - Moulton, Michael J
AU  - Moulton MJ
AD  - Department of Cardiothoracic Surgery, University of Nebraska Medical Center,
      Omaha, NE, USA.
FAU - Um, John Y
AU  - Um JY
AD  - Department of Cardiothoracic Surgery, University of Nebraska Medical Center,
      Omaha, NE, USA.
FAU - Raichlin, Eugenia
AU  - Raichlin E
AUID- ORCID: 0000-0001-9455-5274
AD  - Division of Cardiology, University of Nebraska Medical Center, Omaha, NE, USA.
LA  - eng
PT  - Journal Article
DEP - 20170409
PL  - Denmark
TA  - Clin Transplant
JT  - Clinical transplantation
JID - 8710240
SB  - IM
MH  - Adult
MH  - Exercise Tolerance/*physiology
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Rate
MH  - Heart Transplantation/*adverse effects
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Oxygen Consumption
MH  - Prognosis
MH  - Tachycardia, Sinus/*etiology
MH  - Time Factors
OTO - NOTNLM
OT  - *complication
OT  - *heart (allograft) function/dysfunction
OT  - *quality of life
EDAT- 2017/03/03 06:00
MHDA- 2018/03/27 06:00
CRDT- 2017/03/03 06:00
PHST- 2017/02/23 00:00 [accepted]
PHST- 2017/03/03 06:00 [pubmed]
PHST- 2018/03/27 06:00 [medline]
PHST- 2017/03/03 06:00 [entrez]
AID - 10.1111/ctr.12946 [doi]
PST - ppublish
SO  - Clin Transplant. 2017 May;31(5). doi: 10.1111/ctr.12946. Epub 2017 Apr 9.