PMID- 28247923
OWN - NLM
STAT- MEDLINE
DCOM- 20171124
LR  - 20171128
IS  - 1365-4632 (Electronic)
IS  - 0011-9059 (Linking)
VI  - 56
IP  - 5
DP  - 2017 May
TI  - Regulatory T-cell cytokines in patients with nonsegmental vitiligo.
PG  - 581-588
LID - 10.1111/ijd.13564 [doi]
AB  - In the etiopathogenesis of vitiligo, the role of suppressor cytokines, such as
      transforming growth factor-beta (TGF-beta) and interleukin-10 (IL-10), associated
      with regulatory T-cells (Treg) is not completely known. In this study, the role
      of Treg-cell functions in the skin of patients with nonsegmental vitiligo was
      investigated. Lesional and nonlesional skin samples from 30 adult volunteers
      ranging in age from 18 to 36 years with nonsegmental vitiligo were compared with 
      normal skin area excision specimens of 30 benign melanocytic nevus cases as
      controls. All samples were evaluated staining for forkhead box P3 (Foxp3),
      TGF-beta, and IL-10 using the standardized streptavidin-biotin immunoperoxidase
      immunohistochemistry method. Foxp3 expression was lower in lesional vitiligo skin
      specimens compared to controls; it was also lower in lesional vitiligo specimens 
      than nonlesional vitiligo specimens. IL-10 levels were lower in lesional vitiligo
      specimens compared to the controls, whereas IL-10 expression was significantly
      lower in lesional specimens compared with nonlesional specimens. TGF-beta
      expression was higher in both lesional and nonlesional skin specimens of patients
      with vitiligo compared to controls. TGF-beta expression was lower in lesional
      skin specimens than nonlesional skin specimens. In addition, there was no
      significant correlation between Foxp3 expression with TGF-beta and IL-10
      expressions in lesional skin specimens in the vitiligo group. In this study,
      results supporting the contribution of Treg cells and IL-10 deficiency to the
      autoimmune process were obtained. Therefore, future studies are necessary to
      demonstrate the definitive role of Treg-cell functions in the etiopathogenesis of
      vitiligo.
CI  - (c) 2017 The International Society of Dermatology.
FAU - Kidir, Mehtap
AU  - Kidir M
AD  - Department of Dermatology, School of Medicine, University of Kirikkale,
      Kirikkale, Turkey.
FAU - Karabulut, Ayse A
AU  - Karabulut AA
AD  - Department of Dermatology, School of Medicine, University of Kirikkale,
      Kirikkale, Turkey.
FAU - Ercin, Mustafa E
AU  - Ercin ME
AD  - Department of Pathology, School of Medicine, University of Kirikkale, Kirikkale, 
      Turkey.
FAU - Atasoy, Pinar
AU  - Atasoy P
AD  - Department of Pathology, School of Medicine, University of Kirikkale, Kirikkale, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20170301
PL  - England
TA  - Int J Dermatol
JT  - International journal of dermatology
JID - 0243704
RN  - 0 (FOXP3 protein, human)
RN  - 0 (Forkhead Transcription Factors)
RN  - 0 (Transforming Growth Factor beta)
RN  - 130068-27-8 (Interleukin-10)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Autoimmune Diseases/complications/genetics
MH  - Case-Control Studies
MH  - Female
MH  - Forkhead Transcription Factors/*analysis
MH  - Humans
MH  - Interleukin-10/*analysis/deficiency
MH  - Male
MH  - Middle Aged
MH  - Skin/*chemistry
MH  - T-Lymphocytes, Regulatory/*immunology
MH  - Transforming Growth Factor beta/*analysis
MH  - Vitiligo/complications/*metabolism
MH  - Young Adult
EDAT- 2017/03/02 06:00
MHDA- 2017/11/29 06:00
CRDT- 2017/03/02 06:00
PHST- 2016/05/17 00:00 [received]
PHST- 2016/12/29 00:00 [revised]
PHST- 2017/01/04 00:00 [accepted]
PHST- 2017/03/02 06:00 [pubmed]
PHST- 2017/11/29 06:00 [medline]
PHST- 2017/03/02 06:00 [entrez]
AID - 10.1111/ijd.13564 [doi]
PST - ppublish
SO  - Int J Dermatol. 2017 May;56(5):581-588. doi: 10.1111/ijd.13564. Epub 2017 Mar 1.