PMID- 28193610
OWN - NLM
STAT- MEDLINE
DCOM- 20170328
LR  - 20170514
IS  - 1756-1833 (Electronic)
IS  - 0959-8138 (Linking)
VI  - 356
DP  - 2017 Feb 13
TI  - Risk of heart failure after community acquired pneumonia: prospective controlled 
      study with 10 years of follow-up.
PG  - j413
LID - 10.1136/bmj.j413 [doi]
AB  - Objective To determine the attributable risk of community acquired pneumonia on
      incidence of heart failure throughout the age range of affected patients and
      severity of the infection.Design Cohort study.Setting Six hospitals and seven
      emergency departments in Edmonton, Alberta, Canada, 2000-02.Participants 4988
      adults with community acquired pneumonia and no history of heart failure were
      prospectively recruited and matched on age, sex, and setting of treatment
      (inpatient or outpatient) with up to five adults without pneumonia (controls) or 
      prevalent heart failure (n=23 060).Main outcome measures Risk of hospital
      admission for incident heart failure or a combined endpoint of heart failure or
      death up to 2012, evaluated using multivariable Cox proportional hazards
      analyses.Results The average age of participants was 55 years, 2649 (53.1%) were 
      men, and 63.4% were managed as outpatients. Over a median of 9.9 years
      (interquartile range 5.9-10.6), 11.9% (n=592) of patients with pneumonia had
      incident heart failure compared with 7.4% (n=1712) of controls (adjusted hazard
      ratio 1.61, 95% confidence interval 1.44 to 1.81). Patients with pneumonia aged
      65 or less had the lowest absolute increase (but greatest relative risk) of heart
      failure compared with controls (4.8% v 2.2%; adjusted hazard ratio 1.98, 95%
      confidence interval 1.5 to 2.53), whereas patients with pneumonia aged more than 
      65 years had the highest absolute increase (but lowest relative risk) of heart
      failure (24.8% v 18.9%; adjusted hazard ratio 1.55, 1.36 to 1.77). Results were
      consistent in the short term (90 days) and intermediate term (one year) and
      whether patients were treated in hospital or as outpatients.Conclusion Our
      results show that community acquired pneumonia substantially increases the risk
      of heart failure across the age and severity range of cases. This should be
      considered when formulating post-discharge care plans and preventive strategies, 
      and assessing downstream episodes of dyspnoea.
CI  - Published by the BMJ Publishing Group Limited. For permission to use (where not
      already granted under a licence) please go to
      http://group.bmj.com/group/rights-licensing/permissions.
FAU - Eurich, Dean T
AU  - Eurich DT
AD  - School of Public Health, University of Alberta, Edmonton, Alberta, Canada
      deurich@ualberta.ca.
AD  - ACHORD, 2-040 Li Ka Shing Center, University of Alberta, Edmonton, Alberta,
      Canada, T6G 2E1.
FAU - Marrie, Thomas J
AU  - Marrie TJ
AD  - Department of Medicine, Faculty of Medicine, Dalhousie University, Halifax, Nova 
      Scotia, Canada.
FAU - Minhas-Sandhu, Jasjeet K
AU  - Minhas-Sandhu JK
AD  - ACHORD, 2-040 Li Ka Shing Center, University of Alberta, Edmonton, Alberta,
      Canada, T6G 2E1.
FAU - Majumdar, Sumit R
AU  - Majumdar SR
AD  - School of Public Health, University of Alberta, Edmonton, Alberta, Canada.
AD  - ACHORD, 2-040 Li Ka Shing Center, University of Alberta, Edmonton, Alberta,
      Canada, T6G 2E1.
AD  - Department of Medicine, Faculty of Medicine and Dentistry, University of Alberta,
      Edmonton, Alberta, Canada.
LA  - eng
PT  - Journal Article
DEP - 20170213
PL  - England
TA  - BMJ
JT  - BMJ (Clinical research ed.)
JID - 8900488
SB  - AIM
SB  - IM
MH  - Adult
MH  - Age Factors
MH  - Aged
MH  - Canada/epidemiology
MH  - Cohort Studies
MH  - *Community-Acquired Infections/diagnosis/epidemiology/therapy
MH  - Female
MH  - Health Services Needs and Demand
MH  - *Heart Failure/diagnosis/epidemiology
MH  - Hospitalization/statistics & numerical data
MH  - Humans
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Patient Discharge/standards
MH  - *Pneumonia/diagnosis/epidemiology/therapy
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Survival Analysis
PMC - PMC5421448
EDAT- 2017/02/15 06:00
MHDA- 2017/03/30 06:00
CRDT- 2017/02/15 06:00
PHST- 2017/02/15 06:00 [entrez]
PHST- 2017/02/15 06:00 [pubmed]
PHST- 2017/03/30 06:00 [medline]
PST - epublish
SO  - BMJ. 2017 Feb 13;356:j413.