PMID- 28187783
OWN - NLM
STAT- MEDLINE
DCOM- 20171109
LR  - 20181113
IS  - 1478-6362 (Electronic)
IS  - 1478-6354 (Linking)
VI  - 19
IP  - 1
DP  - 2017 Feb 10
TI  - Development of three-dimensional prints of arthritic joints for supporting
      patients' awareness to structural damage.
PG  - 34
LID - 10.1186/s13075-017-1234-z [doi]
AB  - BACKGROUND: Rheumatoid arthritis (RA) and psoriatic arthritis (PsA) result in
      severe joint destruction and functional disability if left untreated. We aim to
      develop tools that help patients with RA and PsA to understand and experience the
      impact of inflammatory joint disease on the integrity of their (juxta-articular) 
      bone and increase adherence to medical treatment. In this study, we used
      high-resolution peripheral quantitative computed tomography (HR-pQCT) to develop 
      3D prototypes of patients' finger joints. METHODS: HR-pQCT (XtremeCT, Scanco)
      measurements were performed in healthy individuals and patients with inflammatory
      joint disease, followed by a 3D print using the objet30 printer. Healthy
      participants (n = 10), and patients (n = 15 with RA and 15 with PsA) underwent a 
      detailed, standardized interview with demonstration of printed joints. RESULTS:
      Utilizing HR-pQCT images of metacarpophalangeal (MCP) heads, high quality and
      exact 3D prints as prototypes were created. Erosions in different sizes and the
      trabecular network printed in detail were visualized, demonstrating structural
      reduction in arthritic vs. healthy bone. After demonstration of 3D prints
      (healthy vs. erosive joint, visual and haptic) 26/39 (66%) participants
      (including healthy volunteers) were deeply affected, often quoting "shock". Of
      the patients with RA and PsA, 13/15 (86%) and 11/15 (73%), respectively, stated
      that they would rethink their attitude to medication adherence. More importantly,
      21/24 patients with RA or PsA (87.5%) expressed that they would have wished to
      see such 3D prints during their first disease-specific conversations. CONCLUSION:
      Using arthro-haptic 3D printed prototypes of joints may help to better understand
      the impact of inflammatory arthritides on bone integrity and long-term damage.
FAU - Kleyer, Arnd
AU  - Kleyer A
AD  - Department of Internal Medicine 3 - Rheumatology and Immunology,
      Friedrich-Alexander-University Erlangen-Nurnberg (FAU) and Universitatsklinikum
      Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
FAU - Beyer, Laura
AU  - Beyer L
AD  - Department of Internal Medicine 3 - Rheumatology and Immunology,
      Friedrich-Alexander-University Erlangen-Nurnberg (FAU) and Universitatsklinikum
      Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
FAU - Simon, Christoph
AU  - Simon C
AD  - Department of Internal Medicine 3 - Rheumatology and Immunology,
      Friedrich-Alexander-University Erlangen-Nurnberg (FAU) and Universitatsklinikum
      Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
FAU - Stemmler, Fabian
AU  - Stemmler F
AD  - Department of Internal Medicine 3 - Rheumatology and Immunology,
      Friedrich-Alexander-University Erlangen-Nurnberg (FAU) and Universitatsklinikum
      Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
FAU - Englbrecht, Matthias
AU  - Englbrecht M
AD  - Department of Internal Medicine 3 - Rheumatology and Immunology,
      Friedrich-Alexander-University Erlangen-Nurnberg (FAU) and Universitatsklinikum
      Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
FAU - Beyer, Christian
AU  - Beyer C
AD  - Department of Internal Medicine 3 - Rheumatology and Immunology,
      Friedrich-Alexander-University Erlangen-Nurnberg (FAU) and Universitatsklinikum
      Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
FAU - Rech, Jurgen
AU  - Rech J
AD  - Department of Internal Medicine 3 - Rheumatology and Immunology,
      Friedrich-Alexander-University Erlangen-Nurnberg (FAU) and Universitatsklinikum
      Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
FAU - Manger, Bernhard
AU  - Manger B
AD  - Department of Internal Medicine 3 - Rheumatology and Immunology,
      Friedrich-Alexander-University Erlangen-Nurnberg (FAU) and Universitatsklinikum
      Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
FAU - Kronke, Gerhard
AU  - Kronke G
AD  - Department of Internal Medicine 3 - Rheumatology and Immunology,
      Friedrich-Alexander-University Erlangen-Nurnberg (FAU) and Universitatsklinikum
      Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
FAU - Schett, Georg
AU  - Schett G
AD  - Department of Internal Medicine 3 - Rheumatology and Immunology,
      Friedrich-Alexander-University Erlangen-Nurnberg (FAU) and Universitatsklinikum
      Erlangen, Ulmenweg 18, 91054, Erlangen, Germany.
FAU - Hueber, Axel J
AU  - Hueber AJ
AD  - Department of Internal Medicine 3 - Rheumatology and Immunology,
      Friedrich-Alexander-University Erlangen-Nurnberg (FAU) and Universitatsklinikum
      Erlangen, Ulmenweg 18, 91054, Erlangen, Germany. axel.hueber@uk-erlangen.de.
AD  - Department of Internal Medicine 3 and Institute for Clinical Immunology,
      University of Erlangen-Nuremberg, Ulmenweg 18, 90154, Erlangen, Germany.
      axel.hueber@uk-erlangen.de.
LA  - eng
PT  - Journal Article
DEP - 20170210
PL  - England
TA  - Arthritis Res Ther
JT  - Arthritis research & therapy
JID - 101154438
SB  - IM
MH  - Aged
MH  - Arthritis, Psoriatic/*diagnostic imaging/pathology
MH  - Arthritis, Rheumatoid/*diagnostic imaging/pathology
MH  - Female
MH  - Finger Joint/*diagnostic imaging/pathology
MH  - Humans
MH  - Imaging, Three-Dimensional/methods
MH  - Male
MH  - Middle Aged
MH  - Patient Acceptance of Health Care
MH  - *Printing, Three-Dimensional
MH  - Tomography, X-Ray Computed
PMC - PMC5303254
OTO - NOTNLM
OT  - 3D Printing
OT  - Adherence
OT  - Arthritis
OT  - Bone
EDAT- 2017/02/12 06:00
MHDA- 2017/11/10 06:00
CRDT- 2017/02/12 06:00
PHST- 2016/11/18 00:00 [received]
PHST- 2017/01/13 00:00 [accepted]
PHST- 2017/02/12 06:00 [entrez]
PHST- 2017/02/12 06:00 [pubmed]
PHST- 2017/11/10 06:00 [medline]
AID - 10.1186/s13075-017-1234-z [doi]
AID - 10.1186/s13075-017-1234-z [pii]
PST - epublish
SO  - Arthritis Res Ther. 2017 Feb 10;19(1):34. doi: 10.1186/s13075-017-1234-z.