PMID- 28109907
OWN - NLM
STAT- MEDLINE
DCOM- 20170829
LR  - 20171029
IS  - 1872-7980 (Electronic)
IS  - 0304-3835 (Linking)
VI  - 390
DP  - 2017 Apr 1
TI  - Circadian gene variants and breast cancer.
PG  - 137-145
LID - S0304-3835(17)30035-6 [pii]
LID - 10.1016/j.canlet.2017.01.012 [doi]
AB  - The endogenous and self-sustained circadian rhythm generated and maintained in
      suprachiasmatic nucleus and peripheral tissues can coordinate various molecular, 
      biochemical and physiological processes in living organisms resulting in the
      adaptation to environmental cues, e.g. light. Multifactorial breast cancer
      etiology also involves circadian gene alterations, especially among individuals
      exposed to light at night. Indeed, shift work that causes circadian disruption
      has been classified by the International Agency for Research on Cancer as a
      probable human carcinogen, group 2A. Thus it seems extremely important to
      recognize specific susceptible gene variants among around 20 candidate circadian 
      genes that may be linked with breast cancer etiology. The aim of this review was 
      to evaluate recent data investigating a putative link between circadian gene
      polymorphisms and breast cancer risk. We summarize fifteen epidemiological
      studies, including five studies on shift work that have indicated BMAL1, BMAL2,
      CLOCK, NPAS2, CRY1, CRY2, PER1, PER3 and TIMELESS as a candidate breast cancer
      risk variants.
CI  - Copyright (c) 2017 Elsevier B.V. All rights reserved.
FAU - Reszka, Edyta
AU  - Reszka E
AD  - Department of Molecular Genetics and Epigenetics, Nofer Institute of Occupational
      Medicine, Teresy St. 8, 91-348, Lodz, Poland. Electronic address:
      edyta.reszka@imp.lodz.pl.
FAU - Przybek, Monika
AU  - Przybek M
AD  - Department of Molecular Genetics and Epigenetics, Nofer Institute of Occupational
      Medicine, Teresy St. 8, 91-348, Lodz, Poland.
FAU - Muurlink, Olav
AU  - Muurlink O
AD  - Central Queensland University, 160 Ann Street, Brisbane, Australia; Griffith
      Institute of Educational Research, 76 Messines Ridge Road, Mount Gravatt,
      Australia.
FAU - Peplonska, Beata
AU  - Peplonska B
AD  - Department of Environmental Epidemiology, Nofer Institute of Occupational
      Medicine, Teresy St. 8, 91-348, Lodz, Poland.
LA  - eng
PT  - Journal Article
PT  - Review
PT  - Research Support, Non-U.S. Gov't
DEP - 20170118
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
SB  - IM
MH  - Breast Neoplasms/*genetics
MH  - Circadian Clocks/genetics
MH  - Circadian Rhythm/*genetics
MH  - Female
MH  - *Genetic Variation
MH  - Humans
MH  - *Polymorphism, Genetic
MH  - Risk Factors
OTO - NOTNLM
OT  - *Breast cancer
OT  - *Circadian genes
OT  - *Clock genes
OT  - *Genetic polymorphism
OT  - *Shift work
EDAT- 2017/01/23 06:00
MHDA- 2017/08/30 06:00
CRDT- 2017/01/23 06:00
PHST- 2016/10/26 00:00 [received]
PHST- 2017/01/05 00:00 [revised]
PHST- 2017/01/11 00:00 [accepted]
PHST- 2017/01/23 06:00 [pubmed]
PHST- 2017/08/30 06:00 [medline]
PHST- 2017/01/23 06:00 [entrez]
AID - S0304-3835(17)30035-6 [pii]
AID - 10.1016/j.canlet.2017.01.012 [doi]
PST - ppublish
SO  - Cancer Lett. 2017 Apr 1;390:137-145. doi: 10.1016/j.canlet.2017.01.012. Epub 2017
      Jan 18.